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MSDS  : Carvacrol
CAS  : 499-75-2
SYNONYMS  : * Antioxine * Carvacrol * o-Cresol, 5-isopropyl- * p-Cymene, 2-hydroxy- * 2-p-Cymenol * 2-Hydroxy-p-cymene * Isopropyl-o-cresol * 3-Isopropyl-6-methylphenol * 2-Methyl-5-isopropylphenol * 2-Methyl-5-(1-methylethyl)phenol * Phenol, 3-isopropyl-6-methyl- * Phenol, 5-isopropyl-2-methyl- * Phenol, 2-methyl-5-(1-methylethyl)- * o-Thymol
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : FI1225000
CHEMICAL NAME : Carvacrol
CAS REGISTRY NUMBER : 499-75-2
BEILSTEIN REFERENCE NO. : 1860514
REFERENCE : 4-06-00-03331 (Beilstein Handbook Reference)
LAST UPDATED : 199701
DATA ITEMS CITED : 13
MOLECULAR FORMULA : C10-H14-O
MOLECULAR WEIGHT : 150.24
WISWESSER LINE NOTATION : QR B1 EY1&1
COMPOUND DESCRIPTOR : Agricultural Chemical
Drug
Natural Product
Primary Irritant
SYNONYMS/TRADE NAMES :
* Antioxine
* Carvacrol
* o-Cresol, 5-isopropyl-
* p-Cymene, 2-hydroxy-
* 2-p-Cymenol
* 2-Hydroxy-p-cymene
* Isopropyl-o-cresol
* 3-Isopropyl-6-methylphenol
* 2-Methyl-5-isopropylphenol
* 2-Methyl-5-(1-methylethyl)phenol
* Phenol, 3-isopropyl-6-methyl-
* Phenol, 5-isopropyl-2-methyl-
* Phenol, 2-methyl-5-(1-methylethyl)-
* o-Thymol

*** HEALTH HAZARD DATA ***

** SKIN/EYE IRRITATION DATA **

TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/24H
REACTION SEVERITY : Severe
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 17,743,1979

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 810 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 73300 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
REFERENCE :
QJDRAZ Quarterly Journal of Crude Drug Research. (Lisse, Netherlands)
V.1-19, 1961-81. For publisher information, see IJCREE.
Volume(issue)/page/year: 19,1,1981

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 680 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
SIZSAR Sapporo Igaku Zasshi. Sapporo Medical Journal. (Sapporo Igaku
Daigaku, Nishi-17-chome, Minami-1-jo, Chuo-ku, Sapporo 060, Japan) V.3-
1952- Volume(issue)/page/year: 3,73,1952

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 80 mg/kg
TOXIC EFFECTS :
Behavioral - sleep
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
20037) V.6- 1963- Volume(issue)/page/year: 23,1350,1980

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 310 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
France) V.1- 1946- Volume(issue)/page/year: 3,109,1948

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co.,
1956-59 Volume(issue)/page/year: 5,46,1959

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 161,196,1931

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 2700 mg/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see
JPMSAE. Volume(issue)/page/year: 38,366,1949

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co.,
1956-59 Volume(issue)/page/year: 5,46,1959

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Amphibian - frog
DOSE/DURATION : 75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co.,
1956-59 Volume(issue)/page/year: 5,46,1959

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5071
No. of Facilities: 1235 (estimated)
No. of Industries: 6
No. of Occupations: 8
No. of Employees: 7449 (estimated)
No. of Female Employees: 979 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY


*** END OF RECORD ***
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NAMECAS
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Careya herbacea Roxb., extractSUBSTANCE DEFINITION :Plant belonging to the family LecythidaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 18,594,1980 13466-78-9
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5-beta-Card-20(22)-enolide,3-beta-((2,6-dideoxy-4-O-beta-D-glucopyranosyl-3-O-methyl-beta-D-ribo-hexopyranosyl)oxy)-5,14-dihydroxy-19-oxo- 13466-78-9
Carica papaya Linn., unripe fruit pulp extract 13466-78-9
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Carolid 58916-90-8
beta-Carotene, all-trans- 7235-40-7
beta,beta-Carotene,3'-(acetyloxy)-6',7'-didehydro-5,6-epoxy-5,5',6,6',7,8-hexahydro-3,5'- dihydroxy-8-oxo-,(3S,3'S,5R,5'R,6S,6'R)- 3351-86-8
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5-beta-Card-20(22)-enolide,3-beta-((2,6-dideoxy-4-O-beta-D-glucopyranosyl-3-O-methyl-beta-D-ribo-hexopyranosyl)oxy)-5,14-dihydroxy-19-oxo- 560-53-2
beta-Carotene-4,4'-dione, all-trans- 514-78-3
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Carpogenol 72066-23-0
Carrageen 9000-07-1
kappa-Carrageenan 11114-20-8
lambda-Carrageenan 9064-57-7
Carrageenan, calcium(II) salt 9049-05-2
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Carrageenan, sodium salt 9061-82-9
Carriomycin, sodium salt 66007-89-4
Carrot seed oil 8015-88-1
Carthamoidine 72066-24-1
Carthamus oxycantha Bieb., extractSUBSTANCE DEFINITION :Plant belonging to the family CompositaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 18,594,1980 72066-24-1
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Carum strictocarpum Clarke, extractSUBSTANCE DEFINITION :Plant belonging to the family UmbelliferaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 12,512,1974 72066-24-1
Carvacrol 499-75-2
Carvacrol, 5-(2-((2-bromoethyl)ethylamino)ethoxy)-,hydrobromide 16793-55-8
Card-20(22)-enolide,3-((O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-3-O-acetyl-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-3-acetyl-2,6-dideoxy-beta-D-ribo-h exopyranosyl)oxy)-14,16-dihydroxy-, (3-beta,5-beta,16-beta)- 20403-61-6
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Carvacrol,5-(2-(N-(2-chloroethyl)-N-ethylamino)ethoxy)-,acetate, hydrochloride 16825-87-9
Carvacrol,5-(2-(N-(2-chloroethyl)-N-ethylamino)ethoxy)-,benzylate, hydrochloride 73790-26-8
Carvacrol,5-(2-(N-(2-chloroethyl)-N-ethylamino)ethoxy)-,1,5-naphthalenedisulfonate 73771-66-1
Carvacrol,5-(2-(N-(2-chloroethyl)-N-ethylamino)ethoxy)-,3,4,5-trimethoxybenzylate, hydrochloride 73771-67-2
Carvacrol, 5-(2-(dimethylamino)ethoxy)- 35231-36-8
Carvacrol, 5-(2-(N,N-dimethylamino)ethoxy)-, acetate(ester), citrate 26162-66-3
Carvacrol, 5-(2-(N,N-dimethylamino)ethoxy)-, acetate,hydrochloride 964-52-3
Carvacrol, 5-(2-(dimethylamino)ethoxy)-, anthranilate(ester), compd. with 1,5- naphthalenedisulfonic acid(1:1) 16809-76-0
Carvacrol, 5-(2-(N,N-dimethylamino)ethoxy)-,benzylate, hydrochloride 73771-68-3
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