*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : FI1225000
CHEMICAL NAME : Carvacrol
CAS REGISTRY NUMBER : 499-75-2
BEILSTEIN REFERENCE NO. : 1860514
REFERENCE : 4-06-00-03331 (Beilstein Handbook Reference)
LAST UPDATED : 199701
DATA ITEMS CITED : 13
MOLECULAR FORMULA : C10-H14-O
MOLECULAR WEIGHT : 150.24
WISWESSER LINE NOTATION : QR B1 EY1&1
COMPOUND DESCRIPTOR : Agricultural Chemical
Drug
Natural Product
Primary Irritant
SYNONYMS/TRADE NAMES :
* Antioxine
* Carvacrol
* o-Cresol, 5-isopropyl-
* p-Cymene, 2-hydroxy-
* 2-p-Cymenol
* 2-Hydroxy-p-cymene
* Isopropyl-o-cresol
* 3-Isopropyl-6-methylphenol
* 2-Methyl-5-isopropylphenol
* 2-Methyl-5-(1-methylethyl)phenol
* Phenol, 3-isopropyl-6-methyl-
* Phenol, 5-isopropyl-2-methyl-
* Phenol, 2-methyl-5-(1-methylethyl)-
* o-Thymol
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/24H
REACTION SEVERITY : Severe
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 17,743,1979
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 810 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 73300 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
REFERENCE :
QJDRAZ Quarterly Journal of Crude Drug Research. (Lisse, Netherlands)
V.1-19, 1961-81. For publisher information, see IJCREE.
Volume(issue)/page/year: 19,1,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 680 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
SIZSAR Sapporo Igaku Zasshi. Sapporo Medical Journal. (Sapporo Igaku
Daigaku, Nishi-17-chome, Minami-1-jo, Chuo-ku, Sapporo 060, Japan) V.3-
1952- Volume(issue)/page/year: 3,73,1952
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 80 mg/kg
TOXIC EFFECTS :
Behavioral - sleep
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
20037) V.6- 1963- Volume(issue)/page/year: 23,1350,1980
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 310 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
France) V.1- 1946- Volume(issue)/page/year: 3,109,1948
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co.,
1956-59 Volume(issue)/page/year: 5,46,1959
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 161,196,1931
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 2700 mg/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see
JPMSAE. Volume(issue)/page/year: 38,366,1949
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co.,
1956-59 Volume(issue)/page/year: 5,46,1959
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Amphibian - frog
DOSE/DURATION : 75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co.,
1956-59 Volume(issue)/page/year: 5,46,1959
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5071
No. of Facilities: 1235 (estimated)
No. of Industries: 6
No. of Occupations: 8
No. of Employees: 7449 (estimated)
No. of Female Employees: 979 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Carex japonica Thunb., extractSUBSTANCE DEFINITION :Plant belonging to the family CyperaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 18,594,1980
| 13466-78-9 |
Careya arborea Roxb., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family LecythidaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 13466-78-9 |
Careya herbacea Roxb., extractSUBSTANCE DEFINITION :Plant belonging to the family LecythidaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 18,594,1980
| 13466-78-9 |
Carica papaya, seed extract
| 13466-78-9 |
5-beta-Card-20(22)-enolide,3-beta-((2,6-dideoxy-4-O-beta-D-glucopyranosyl-3-O-methyl-beta-D-ribo-hexopyranosyl)oxy)-5,14-dihydroxy-19-oxo-
| 13466-78-9 |
Carica papaya Linn., unripe fruit pulp extract
| 13466-78-9 |
Carissa congesta Wight, extractSUBSTANCE DEFINITION :Plant belonging to the family ApocynaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 13466-78-9 |
Carissa inermis Vahl., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family ApocynaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 13466-78-9 |
Carissapaucinervia A. DC., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family ApocynaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 26,883,1988
| 13466-78-9 |
Carissa spinarum Linn., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family ApocynaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 13466-78-9 |
Carissa spinarum Linn. var. microphylla Gamble,extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family ApocynaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 24,48,1986
| 13466-78-9 |
Carmine
| 1390-65-4 |
Carolid
| 58916-90-8 |
beta-Carotene, all-trans-
| 7235-40-7 |
beta,beta-Carotene,3'-(acetyloxy)-6',7'-didehydro-5,6-epoxy-5,5',6,6',7,8-hexahydro-3,5'- dihydroxy-8-oxo-,(3S,3'S,5R,5'R,6S,6'R)-
| 3351-86-8 |
5-beta-Card-20(22)-enolide,3-beta-((6-deoxy-3-O-methyl-beta-L-glucopyranosyl)oxy)-14- hydroxy-, 4',14-diacetate
| 101418-21-7 |
5-beta-Card-20(22)-enolide,3-beta-((2,6-dideoxy-4-O-beta-D-glucopyranosyl-3-O-methyl-beta-D-ribo-hexopyranosyl)oxy)-5,14-dihydroxy-19-oxo-
| 560-53-2 |
beta-Carotene-4,4'-dione, all-trans-
| 514-78-3 |
Carpesium abrotanioides Linn., extractSUBSTANCE DEFINITION :Plant belonging to the family AsteraceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 22,312,1984
| 514-78-3 |
Carpinus viminea Wall. ex Lindl., extract excludingrootsSUBSTANCE DEFINITION :Plant belonging to the family BetulaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 514-78-3 |
Carpogenol
| 72066-23-0 |
Carrageen
| 9000-07-1 |
kappa-Carrageenan
| 11114-20-8 |
lambda-Carrageenan
| 9064-57-7 |
Carrageenan, calcium(II) salt
| 9049-05-2 |
Carrageenan, degradedSUBSTANCE DEFINITION :Carrageenan derived from Eucheuma spinosum, degraded by acid hydrolysis -average molecular weight 20,000-40,000REFERENCE :CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. IrelandLtd., POB 85, Limerick, Ireland) V.1- 1975-
| 9049-05-2 |
Carrageenan, nativeSUBSTANCE DEFINITION :A hydrocolloid isolated from various red algae (seaweed)REFERENCE :IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicalsto Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)V.1- 1972-
| 9049-05-2 |
Card-20(22)-enolide,3-((O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-3-O-acetyl-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-3-acetyl-2,6-dideoxy-beta-D-ri bo-hexopyranosyl)oxy)-16-(acetyloxy)-14-hydroxy-,(3-beta,5-beta,16-beta)-
| 20231-89-4 |
Carrageenan, potassium salt
| 64366-24-1 |
Carrageenan, sodium salt
| 9061-82-9 |
Carriomycin, sodium salt
| 66007-89-4 |
Carrot seed oil
| 8015-88-1 |
Carthamoidine
| 72066-24-1 |
Carthamus oxycantha Bieb., extractSUBSTANCE DEFINITION :Plant belonging to the family CompositaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 18,594,1980
| 72066-24-1 |
Carthamus tinctorius L., extractSUBSTANCE DEFINITION :Plant belonging to the family CompositaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 72066-24-1 |
Carum strictocarpum Clarke, extractSUBSTANCE DEFINITION :Plant belonging to the family UmbelliferaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 12,512,1974
| 72066-24-1 |
Carvacrol
| 499-75-2 |
Carvacrol, 5-(2-((2-bromoethyl)ethylamino)ethoxy)-,hydrobromide
| 16793-55-8 |
Card-20(22)-enolide,3-((O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-3-O-acetyl-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-3-acetyl-2,6-dideoxy-beta-D-ribo-h exopyranosyl)oxy)-14,16-dihydroxy-, (3-beta,5-beta,16-beta)-
| 20403-61-6 |
Carvacrol, 5-chloro-
| 5665-94-1 |
Carvacrol,5-(2-(N-(2-chloroethyl)-N-ethylamino)ethoxy)-,acetate, hydrochloride
| 16825-87-9 |
Carvacrol,5-(2-(N-(2-chloroethyl)-N-ethylamino)ethoxy)-,benzylate, hydrochloride
| 73790-26-8 |
Carvacrol,5-(2-(N-(2-chloroethyl)-N-ethylamino)ethoxy)-,1,5-naphthalenedisulfonate
| 73771-66-1 |
Carvacrol,5-(2-(N-(2-chloroethyl)-N-ethylamino)ethoxy)-,3,4,5-trimethoxybenzylate, hydrochloride
| 73771-67-2 |
Carvacrol, 5-(2-(dimethylamino)ethoxy)-
| 35231-36-8 |
Carvacrol, 5-(2-(N,N-dimethylamino)ethoxy)-, acetate(ester), citrate
| 26162-66-3 |
Carvacrol, 5-(2-(N,N-dimethylamino)ethoxy)-, acetate,hydrochloride
| 964-52-3 |
Carvacrol, 5-(2-(dimethylamino)ethoxy)-, anthranilate(ester), compd. with 1,5- naphthalenedisulfonic acid(1:1)
| 16809-76-0 |
Carvacrol, 5-(2-(N,N-dimethylamino)ethoxy)-,benzylate, hydrochloride
| 73771-68-3 |
5-beta-Card-20(22)-enolide,3-beta-((O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyrano syl)oxy)-14,16-alpha-dihydroxy-, 16-acetate
| 29362-48-9 |
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