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MSDS  : Conjugated estrogenic hormones
CAS  : 12126-59-9
SYNONYMS  : * Amnestrogen * Climestrone * CO-Estro * Conest * Conestron * Conjes * Conjugated estrogens * Conjutabs * Equigyne * Estratab * Estrifol * Estroate * Estrocon * Estromed * Estropan * Femacoid * Femest * FEM H * Formatrix * Ganeake * Genisis * Glyestrin * Kestrin * Menest * Menogen * Menotab * Menotrol * Msmed * Novoconestron * Oestrilin * Oestro-feminal * Oestropak morning * Ovest * Palopause * Par estro * PMB * Presomen * Promarit * SK-Estrogens * Sodestrin-H * TAG-39 * Theogen * Transannon * Trocosone * Zeste
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : GL1224000
CHEMICAL NAME : Conjugated estrogenic hormones
CAS REGISTRY NUMBER : 12126-59-9
LAST UPDATED : 199510
DATA ITEMS CITED : 6
COMPOUND DESCRIPTOR : Tumorigen
Drug
Reproductive Effector
Human
Hormone
Natural Product
SYNONYMS/TRADE NAMES :
* Amnestrogen
* Climestrone
* CO-Estro
* Conest
* Conestron
* Conjes
* Conjugated estrogens
* Conjutabs
* Equigyne
* Estratab
* Estrifol
* Estroate
* Estrocon
* Estromed
* Estropan
* Femacoid
* Femest
* FEM H
* Formatrix
* Ganeake
* Genisis
* Glyestrin
* Kestrin
* Menest
* Menogen
* Menotab
* Menotrol
* Msmed
* Novoconestron
* Oestrilin
* Oestro-feminal
* Oestropak morning
* Ovest
* Palopause
* Par estro
* PMB
* Presomen
* Promarit
* SK-Estrogens
* Sodestrin-H
* TAG-39
* Theogen
* Transannon
* Trocosone
* Zeste

*** HEALTH HAZARD DATA ***

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 108 mg/kg/4Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Vascular - tumors
Liver - tumors
REFERENCE :
AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago,
IL 60610) V.1- 1908- Volume(issue)/page/year: 137,357,1977

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 27 mg/kg/3Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
REFERENCE :
NYSJAM New York State Journal of Medicine. (Medical Soc. of the State of
New York, POB 5405, Lake Success, NY 11042) V.1- 1901-
Volume(issue)/page/year: 78,1933,1978

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Human - woman
DOSE : 3 mg/kg
SEX/DURATION : female 1-5 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year:
244,1336,1980

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Primate - monkey
DOSE : 4167 ug/kg
SEX/DURATION : female 1-5 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-
Volume(issue)/page/year: 115,101,1973

*** REVIEWS ***

IARC Cancer Review:Animal Limited Evidence
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,283,1987

*** STATUS IN U.S. ***

NTP 7th Annual Report on Carcinogens, 1992 : known to be carcinogenic


*** END OF RECORD ***
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