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MSDS  : Copper, (5-((4'-((2,5-dihydroxy-4-((2-hydroxy-5-sulfophenyl)a zo)phenyl)azo)(1,1'-b iphenyl)- 4-yl)azo)-2-hydroxybenzoato(2-))-, disodium salt
CAS  : 16071-86-6
SYNONYMS  : * Aizen Primula Brown BRLH * Aizen Primula Brown PLH * Amanil Fast Brown BRL * Amanil Supra Brown LBL * Atlantic Fast Brown BRL * Atlantic Resin Fast Brown BRL * Belamine Fast Brown BRLL * Benzamil Supra Brown BRLL * Benzanil Supra Brown BRLN * Brown 4EMBL * Calcodur Brown BRL * Chloramine Fast Brown BRL * Chloramine Fast Brown BRLL * Chloramine Fast Cutch Brown PL * Chrome Leather Brown BRLL * Chrome Leather Brown BRSL * C.I. 30145 * C.I. Direct Brown * Cuprofix Brown GL * Derma Fast Brown W-GL * Dermafix Brown PL * Dialuminous Brown BRS * Diaphtamine Light Brown BRLL * Diazine Fast Brown RSL * Diazol Light Brown BRN * Dicorel Brown LMR * Diphenyl Fast Brown BRL * Direct Brown 95 * Direct Brown BRL * Direct Fast Brown BRL * Direct Fast Brown LMR * Direct Light Brown BRS * Direct Supra Light Brown ML * Durazol Brown BR * DuroFast Brown BRL * Eliamina Light Brown BRL * Enianil Light Brown BRL * Fastolite Brown BRL * Fastusol Brown LBRSA * Fastusol Brown LBRSN * Fenaluz Brown BRL * Helion Brown BRSL * Hispaluz Brown BRL * Hned prima 95 * Kayarus Supra Brown BRS * Kca Light Fast Brown BR * NCI-C54568 * Paranol Fast Brown BRL * Peeramine Fast Brown BRL * Pontamine Fast Brown BRL * Pontamine Fast Brown NP * Pyrazol Fast Brown BRL * Pyrazoline Brown BRL * Saturn Brown LBR * Sirius Supra Brown BRL * Sirius Supra Brown BRS * Solantine Brown BRL * Solar Brown PL * Solex Brown R * Solius Light Brown BRLL * Solius Light Brown BRS * Sumilight Supra Brown BRS * Suprazo Brown BRL * Suprexcel Brown BRL * Tertrodirect Fast Brown BR * Tetramine Fast Brown BRDN Extra * Tetramine Fast Brown BRP * Tetramine Fast Brown BRS * Triantine Brown BRS * Triantine Fast Brown OG * Triantine Fast Brown OR * Triantine Light Brown BRS * Triantine Light Brown OG
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : GL7375000
CHEMICAL NAME : Copper,
(5-((4'-((2,5-dihydroxy-4-((2-hydroxy-5-sulfophenyl)a
zo)phenyl)azo)(1,1'-b iphenyl)-
4-yl)azo)-2-hydroxybenzoato(2-))-, disodium salt
CAS REGISTRY NUMBER : 16071-86-6
LAST UPDATED : 199712
DATA ITEMS CITED : 23
MOLECULAR FORMULA : C31-H18-Cu-N6-O9-S.2Na
MOLECULAR WEIGHT : 760.13
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Aizen Primula Brown BRLH
* Aizen Primula Brown PLH
* Amanil Fast Brown BRL
* Amanil Supra Brown LBL
* Atlantic Fast Brown BRL
* Atlantic Resin Fast Brown BRL
* Belamine Fast Brown BRLL
* Benzamil Supra Brown BRLL
* Benzanil Supra Brown BRLN
* Brown 4EMBL
* Calcodur Brown BRL
* Chloramine Fast Brown BRL
* Chloramine Fast Brown BRLL
* Chloramine Fast Cutch Brown PL
* Chrome Leather Brown BRLL
* Chrome Leather Brown BRSL
* C.I. 30145
* C.I. Direct Brown
* Cuprofix Brown GL
* Derma Fast Brown W-GL
* Dermafix Brown PL
* Dialuminous Brown BRS
* Diaphtamine Light Brown BRLL
* Diazine Fast Brown RSL
* Diazol Light Brown BRN
* Dicorel Brown LMR
* Diphenyl Fast Brown BRL
* Direct Brown 95
* Direct Brown BRL
* Direct Fast Brown BRL
* Direct Fast Brown LMR
* Direct Light Brown BRS
* Direct Supra Light Brown ML
* Durazol Brown BR
* DuroFast Brown BRL
* Eliamina Light Brown BRL
* Enianil Light Brown BRL
* Fastolite Brown BRL
* Fastusol Brown LBRSA
* Fastusol Brown LBRSN
* Fenaluz Brown BRL
* Helion Brown BRSL
* Hispaluz Brown BRL
* Hned prima 95
* Kayarus Supra Brown BRS
* Kca Light Fast Brown BR
* NCI-C54568
* Paranol Fast Brown BRL
* Peeramine Fast Brown BRL
* Pontamine Fast Brown BRL
* Pontamine Fast Brown NP
* Pyrazol Fast Brown BRL
* Pyrazoline Brown BRL
* Saturn Brown LBR
* Sirius Supra Brown BRL
* Sirius Supra Brown BRS
* Solantine Brown BRL
* Solar Brown PL
* Solex Brown R
* Solius Light Brown BRLL
* Solius Light Brown BRS
* Sumilight Supra Brown BRS
* Suprazo Brown BRL
* Suprexcel Brown BRL
* Tertrodirect Fast Brown BR
* Tetramine Fast Brown BRDN Extra
* Tetramine Fast Brown BRP
* Tetramine Fast Brown BRS
* Triantine Brown BRS
* Triantine Fast Brown OG
* Triantine Fast Brown OR
* Triantine Light Brown BRS
* Triantine Light Brown OG

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 12060 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection
Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
Volume(issue)/page/year: OTS 215154

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection
Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
Volume(issue)/page/year: OTS 215154

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2625 mg/kg/5W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-108,1978

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 6825 mg/kg/13W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
54,431,1980

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 100 nmol
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 136,33,1984

TYPE OF TEST : Unscheduled DNA synthesis
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 100 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 136,147,1984

TYPE OF TEST : Body fluid assay
TEST SYSTEM : Rodent - rat Bacteria - Salmonella typhimurium
DOSE/DURATION : 250 umol/kg
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 31,271,1984

*** REVIEWS ***

IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 29,321,1982

IARC Cancer Review:Animal Sufficient Evidence
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,125,1987

IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 29,321,1982

*** OCCUPATIONAL EXPOSURE LIMITS ***

OEL-FINLAND;Carcinogen JAN 1993

OEL-FRANCE;Carcinogen JAN 1993

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M1412
No. of Facilities: 37 (estimated)
No. of Industries: 3
No. of Occupations: 11
No. of Employees: 1112 (estimated)

NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M1412
No. of Facilities: 119 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 830 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA Section 8(d) unpublished health/safety studies

On EPA IRIS database

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

NIOSH CURRENT INTELLIGENCE BULLETIN 24, 1978

NIOSH Analytical Method, 1994: Dyes, 5013

NCI Carcinogenesis Bioassay (feed);clear evidence:rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-108,78

NCI Carcinogenesis Bioassay (feed);no evidence:mouse
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-108,78

NTP Toxicity studies, RPT# TR-108, October 1997


*** END OF RECORD ***
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