*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : GL7000000
CHEMICAL NAME : Copper(II) chloride (1:2)
CAS REGISTRY NUMBER : 7447-39-4
LAST UPDATED : 199710
DATA ITEMS CITED : 47
MOLECULAR FORMULA : Cl2-Cu
MOLECULAR WEIGHT : 134.44
WISWESSER LINE NOTATION : CU G2
COMPOUND DESCRIPTOR : Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Copper bichloride
* Copper(2+) chloride
* Copper(II) chloride
* Cupric chloride
* Cupric dichloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 584 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas
Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)-
Volume(issue)/page/year: 23,153,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 14700 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas
Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)-
Volume(issue)/page/year: 23,153,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 5 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas
Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)-
Volume(issue)/page/year: 23,153,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 233 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas
Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)-
Volume(issue)/page/year: 23,153,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 7400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 244,17,1962
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 17500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
(Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
V.9- 1974- Volume(issue)/page/year: 19,425,1984
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 20 ug/m3/26W-I
TOXIC EFFECTS :
Blood - changes in leukocyte (WBC) count
Nutritional and Gross Metabolic - changes in chlorine
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 52(7),74,1987
** REPRODUCTIVE DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE : 8 ug/m3
SEX/DURATION : female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 51(8),38,1986
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 35 mg/kg
SEX/DURATION : female 12-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 64,19,1990
** MUTATION DATA **
TYPE OF TEST : DNA damage
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 2 mmol/L
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:
198,513,1977
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 100 umol/L
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA,
1255 Howard St., San Francisco, CA 94103) V.6- 1958-
Volume(issue)/page/year: 33,1571,1985
TYPE OF TEST : DNA damage
TEST SYSTEM : Mammal - species unspecified Lymphocyte
DOSE/DURATION : 2 mmol/L
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:
198,513,1977
*** REVIEWS ***
TOXICOLOGY REVIEW
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series,"
Washington, DC, National Academy of Sciences, 1972-77
Volume(issue)/page/year: Cu,23,1977
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.1 mg(Cu)/m3 (fume) JAN 1993
OEL-AUSTRALIA:TWA 0.2 mg(Cu)/m3 (fume) JAN 1993
OEL-AUSTRALIA:TWA 1 mg(Cu)/m3 (dust) JAN 1993
OEL-BELGIUM:TWA 0.2 mg(Cu)/m3 (fume) JAN 1993
OEL-BELGIUM:TWA 1 mg(Cu)/m3 (dust) JAN 1993
OEL-DENMARK:TWA 0.1 mg(Cu)/m3 (fume) JAN 1993
OEL-DENMARK:TWA 1 mg(Cu)/m3 (dust) JAN 1993
OEL-FINLAND:TWA 0.2 mg(Cu)/m3 (fume) JAN 1993
OEL-FINLAND:TWA 1 mg(Cu)/m3 (dust) JAN 1993
OEL-FRANCE:TWA 0.2 mg(Cu)/m3 (fume) JAN 1993
OEL-FRANCE:TWA 1 mg(Cu)/m3;STEL 2 mg(Cu)/m3 (dust) JAN 1993
OEL-GERMANY:TWA 0.1 mg(Cu)/m3 (fume) JAN 1993
OEL-GERMANY:TWA 1 mg(Cu)/m3 (dust) JAN 1993
OEL-HUNGARY:TWA 0.2 mg(Cu)/m3;STEL 0.4 mg(Cu)/m3 (dust) JAN 1993
OEL-INDIA:TWA 0.2 mg(Cu)/m3 (fume) JAN 1993
OEL-THE NETHERLANDS:TWA 02 mg(Cu)/m3 (fume) JAN 1993
OEL-THE NETHERLANDS:TWA 1 mg(Cu)/m3 (dust) JAN 1993
OEL-THE PHILIPPINES:TWA 1.0 mg(Cu)/m3 (fume) JAN 1993
OEL-POLAND:TWA 0.1 mg(Cu)/m3 (fume) JAN 1993
OEL-RUSSIA:STEL 0.5 ppm (1 mg(Cu)/m3) (dust) JAN 1993
OEL-SWEDEN:TWA 0.2 mg(Cu)/m3 (resp. dust) JAN 1993
OEL-SWEDEN:TWA 0.2 mg(Cu)/m3 (fume) JAN 1993
OEL-SWEDEN:TWA 1 mg(Cu)/m3 (total dust) JAN 1993
OEL-SWITZERLAND:TWA 0.1 mg(Cu)/m3;STEL 0.2 mg(Cu)/m3 (fume) JAN 1993
OEL-SWITZERLAND:TWA 1 mg(Cu)/m3;STEL 1 mg(Cu)/m3 JAN 1993
OEL-THAILAND:TWA 0.1 mg(Cu)/m3 (fume) JAN 1993
OEL-THAILAND:TWA 1 mg(Cu)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.2 mg(Cu)/m3 (fume) JAN 1993
OEL-UNITED KINGDOM:TWA 1 mg(Cu)/m3 JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X9857
No. of Facilities: 1154 (estimated)
No. of Industries: 20
No. of Occupations: 28
No. of Employees: 16759 (estimated)
No. of Female Employees: 9684 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***
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| ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| | NAME | CAS |
|
Copper alloy, Cu 99.75-100, Cd 0.05-0.15 (uns C14300)
| 132295-56-8 |
|
Copper alloy, Cu 99.60-100, Cd 0.10-0.30 (uns C14310)
| 132295-57-9 |
|
Copper,(4-aminobutanoato-N,O)(N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-beta-alan inato)-
| 85625-88-3 |
|
Copper, ammine(benzenecarbothioic acid((2-hydroxyphenyl)methylene)hydrazidato(2-))-
| 132854-23-0 |
|
Copper, (D-arabino-hexos-2-ulosebis((aminothioxomethyl)hydrazonato)(2-))- (SP-4-4)-
| 54446-28-5 |
|
Copper, ((arabino-hexos-2-ulosebis(((((3-bromo-4-ethoxyphenyl)methyl)amino)thioxomethyl) hydrazonato))(2-))-
| 95148-34-8 |
|
Copper, ((arabino-hexos-2-ulosebis(((((3-bromo-4-methoxyphenyl)methyl)amino)thioxomethyl) hydrazonato))(2-))-
| 95148-32-6 |
|
Copper, ((arabino-hexos-2-ulosebis(((((4-ethoxyphenyl)methyl)amino)thioxomethyl)hydrazonato))(2-))-
| 95148-33-7 |
|
Clematis graveolens Lindl., extractSUBSTANCE DEFINITION :Plant belonging to the family RanunculaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 95148-33-7 |
|
Copper, ((arabino-hexos-2-ulosebis(((((4-methoxyphenyl)methyl)amino)thioxomethyl)hydrazonato))(2-))-
| 95148-31-5 |
|
Copper arsenide
| 12006-17-6 |
|
Copper, (D-aspartato(2-))-
| 57609-00-4 |
|
Copper, (L-aspartato(2-))-
| 57609-01-5 |
|
Copper, (3-azabicyclo(3.2.2)nonane-3-carbothioic acid(1-(2-pyridinyl)ethylidene)hydrazideN-oxidato)chloro-
| 87587-22-2 |
|
Copper,(benzoicacid((2-hydroxyphenyl)methylene)hydrazidato)chloro-, monohydrate (SP-4-4)-
| 83614-45-3 |
|
Copper, bis(acetato)hexametaarsenitotetra-
| 12002-03-8 |
|
Copper(2+),(N,N'-bis(2-aminoethyl)-1,2-ethanediamine-N,N',N'',N''')-, dichloride
| 94955-60-9 |
|
Copper, (bis(anthranilato)-
| 15442-49-6 |
|
Copper,bis(benzoato-O)(3-(1-methyl-2-pyrrolidinyl)pyridine-N(sup 1))-, (S)-
| 64092-17-7 |
|
Clematis hedysarifolia DC., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family RanunculaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 26,883,1988
| 64092-17-7 |
|
Copper,bis(4-butyl-1,2-diphenyl-3,5-pyrazolidinedionato)-
| 64092-17-7 |
|
Copper,bis(dihydrogen-8-hydroxy-5,7-quinolinedisulfonato)-,comp. with diethylamine (1:4)
| 13007-93-7 |
|
Copper, bis(3,5-diisopropylsalicylato)-
| 21246-18-4 |
|
Copper, bis(3,3'-dithiobis(D-valinato)-N,O)-,(SP-4-1)-
| 57596-07-3 |
|
Copper(II), bis(dithiocarbanilato)-
| 25500-28-1 |
|
Copper, bis(1,2-ethanediamine-N,N')-,(T-4)-tetraoxotungstate(2-) (1:1), dihydrate
| 25500-28-1 |
|
Copper(2+), bis(ethylenediamine)-,tetrakis(thiocyanato)mercurate(2-), polymers
| 29471-80-5 |
|
Copper, bis(2-furancarboxylato-O(sup 1),O(sup 2))-
| 84009-23-4 |
|
Copper, bis(2-hydroxybenzoato-O(sup 1),O(sup2))(3-(1-methyl-2-pyrrolidinyl)pyridine- N(sup 1))-
| 64092-19-9 |
|
Copper,bis(2-hydroxy-3,5-bis(1-methylethyl)benzoato-O(sup1),O(sup 2))-, (SP-4-1)-
| 57636-92-7 |
|
Clematis montana Buch.-Ham ex DC., extractSUBSTANCE DEFINITION :Plant belonging to the family RanunculaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 57636-92-7 |
|
Copper,bis(mu-(2-(((2-hydroxyphenyl)methylene)amiino)benzoato(2-)-N(sup 2),O(sup 1), O(sup 2),O(sup 1')))di-
| 54775-37-0 |
|
Copper, bis(isonicotinic acid hydrazide)-, trihydrate
| 54775-37-0 |
|
Copper, bis(D-mandelato)-
| 54775-37-0 |
|
Copper, bis(D,L-mandelato)-
| 15731-16-5 |
|
Copper, bis(L-mandelato)-
| 15731-16-5 |
|
Copper(II), bis(3-mercaptovalinato)diaqua-, D-,polymers
| 72794-47-9 |
|
Copper, bis(N-methylthioformohydroxamato)-
| 31323-25-8 |
|
Copper, bis(2,4-pentanedionato)-
| 13395-16-9 |
|
Copper,bis(3-((phenylamino)methyl)-2(3H)-benzoxazolone-N(supN(sup 3),O(sup 2))bis (thiocyanato-N))-
| 82498-01-9 |
|
Copper(II), bis(3-phenylsalicylato)-
| 5328-04-1 |
|
Clematis montana buch-ham, extract
| 5328-04-1 |
|
Copper(2+), bis(1,2-propanediamine-N,N')-,(T-4)-tetraoxotungstate(2-) (1:1), dihydrate
| 5328-04-1 |
|
Copper, bis(D-tryptophanato-N,O)-, (SP-4-1)-
| 57636-91-6 |
|
Copper, bis(L-tryptophanato-N,O)-, (SP-4-1)-
| 57636-95-0 |
|
Copper,(4-bromo-3-hydroxy-2-naphthoato)(8-quinolinolato)-
| 14039-99-7 |
|
Copper(II) carbonate hydroxide (212)
| 12069-69-1 |
|
Copper(I) chloride
| 7758-89-6 |
|
Copper(II) chloride (12)
| 7447-39-4 |
|
Copper chloride, mixed with copper oxide, hydrate
| 1332-40-7 |
|
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