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MSDS  : Coumarin, 7-hydroxy-4-methyl-
CAS  : 90-33-5
SYNONYMS  : * 2H-1-Benzopyran, 7-hydroxy-4-methyl-2-oxo- * 2H-1-Benzopyren-2-one, 7-hydroxy-4-methyl- * Bilcolic * Bilicante * Cantabilin * Cantabiline * Coumarin 4 * Eurogale * 7-Hydroxy-4-methylcoumarin * 7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran * Hymecromon * Hymecromone * Imecromone * LM 94 * Medilla * Mendiaxon * 4-Methyl-7-hydroxycoumarin * 4-Methylumbelliferon * beta-Methylumbelliferone * 4-Methylumbelliferone * Omega 127 * Pilot 447
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : GN7000000
CHEMICAL NAME : Coumarin, 7-hydroxy-4-methyl-
CAS REGISTRY NUMBER : 90-33-5
BEILSTEIN REFERENCE NO. : 0142217
REFERENCE : 5-18-01-00439 (Beilstein Handbook Reference)
LAST UPDATED : 199710
DATA ITEMS CITED : 15
MOLECULAR FORMULA : C10-H8-O3
MOLECULAR WEIGHT : 176.18
WISWESSER LINE NOTATION : T66 BOVJ E1 IQ
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
SYNONYMS/TRADE NAMES :
* 2H-1-Benzopyran, 7-hydroxy-4-methyl-2-oxo-
* 2H-1-Benzopyren-2-one, 7-hydroxy-4-methyl-
* Bilcolic
* Bilicante
* Cantabilin
* Cantabiline
* Coumarin 4
* Eurogale
* 7-Hydroxy-4-methylcoumarin
* 7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran
* Hymecromon
* Hymecromone
* Imecromone
* LM 94
* Medilla
* Mendiaxon
* 4-Methyl-7-hydroxycoumarin
* 4-Methylumbelliferon
* beta-Methylumbelliferone
* 4-Methylumbelliferone
* Omega 127
* Pilot 447

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3850 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Sense Organs and Special Senses (Eye) - ptosis
Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 5,1619,1971

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2550 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Sense Organs and Special Senses (Eye) - ptosis
Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 5,1619,1971

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 7200 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Skin and Appendages - hair
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 5,1619,1971

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2850 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Sense Organs and Special Senses (Eye) - ptosis
Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 5,1619,1971

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New
York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year:
21,555,1958

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >10 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Skin and Appendages - hair
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 5,1619,1971

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 56 gm/kg/4W-C
TOXIC EFFECTS :
Liver - changes in liver weight
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 4,1001,1970

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 182 gm/kg/26W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in pituitary weight
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 4,1001,1970

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 6 gm/kg
SEX/DURATION : female 9-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
GNRIDX Gendai no Rinsho. (Tokyo, Japan) V.1-10, 1967-76(?).
Volume(issue)/page/year: 4,413,1970

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 6 gm/kg
SEX/DURATION : female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
GNRIDX Gendai no Rinsho. (Tokyo, Japan) V.1-10, 1967-76(?).
Volume(issue)/page/year: 4,403,1970

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 1500 mg/kg
SEX/DURATION : female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth
REFERENCE :
GNRIDX Gendai no Rinsho. (Tokyo, Japan) V.1-10, 1967-76(?).
Volume(issue)/page/year: 4,403,1970

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X7017
No. of Facilities: 25 (estimated)
No. of Industries: 2
No. of Occupations: 4
No. of Employees: 2001 (estimated)
No. of Female Employees: 395 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA Section 8(d) unpublished health/safety studies

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Coumarin, 7-(3-(dimethylamino)propoxy)-3-(4-pyridyl)- 5913-19-9
Coumarin, 4,7-dimethyl-5-hydroxy- 6335-27-9
Coumarin, 4,6-dimethyl-7-methylamino- 26078-24-0
Coumarin, 8-((3,7-dimethyl-2-octenyl)oxy)-7-hydroxy- 98299-78-6
Coumarin, 3-(2,3-dimethylphenyl)-4-hydroxy- 73791-09-0
Coumarin, 3-(2,4-dimethylphenyl)-4-hydroxy- 73791-10-3
Coumarin, 3-(2,5-dimethylphenyl)-4-hydroxy- 73791-11-4
Clostomycin D 106008-72-4
Coumarin, 3-(2,6-dimethylphenyl)-4-hydroxy- 73791-12-5
Coumarin, 3-(3,4-dimethylphenyl)-4-hydroxy- 73791-13-6
Coumarin, 3-(3,5-dimethylphenyl)-4-hydroxy- 15301-97-0
Coumarin, 3,4-diphenyl-7-hydroxy-, acetate (ester) 1508-89-0
Coumarin,3-((2-(dipropylamino)ethyl)carbamoyl)-4-hydroxy-8-methyl-, monohydrochloride 19225-12-8
Coumarin, 4-dipropylamino-3-nitro- 50527-32-7
Coumarin, 3-ethyl- 66898-39-3
Coumarin, 3-(alpha-ethylbenzyl)-4-hydroxy- 435-97-2
Coumarin, 4-ethyl-7-hydroxy-3-(p-methoxyphenyl)- 5219-17-0
Coumarin, 3-(o-ethylphenyl)-4-hydroxy- 73791-14-7
Clostridium butyricum miyairi, powder 73791-14-7
Coumarin, 3-glyoxyloyl- 91635-05-1
Coumarin, 3-glyoxyloyl-8-methoxy- 92024-91-4
Coumarin, 3-hydroxy- 939-19-5
Coumarin, 7-hydroxy- 93-35-6
Coumarin, 4-hydroxy-3-(alpha-(2-hydroxyallyl)benzyl)- 101468-14-8
Coumarin, 4-hydroxy-3-((2-hydroxy-1-naphthyl)methyl)- 19225-16-2
Coumarin, 7-hydroxy-3-(p-hydroxyphenyl)-4-phenyl- 100242-24-8
Coumarin, 4-hydroxy-6-iodo-3-(1-naphthyl-3-oxobutyl)- 13021-90-4
Coumarin,6-(2-hydroxy-3-isobutylaminopropoxy)-7-methoxy-4-methyl-, hydrochloride 63446-03-7
Coumarin,7-(2-hydroxy-3-isobutylaminopropoxy)-6-methoxy-4-methyl-, hydrochloride 63446-02-6
Citric acid, yttrium salt (31) 63938-20-5
Clove oil, leaf 8000-34-8
Coumarin, 4-hydroxy-3-(o-isopropylphenyl)- 73791-15-8
Coumarin, 7-hydroxy-6-methoxy- 92-61-5
Coumarin, 7-hydroxy-6-methoxy-3,7'-oxydi- 2034-69-7
Coumarin, 7-hydroxy-3-(p-methoxyphenyl)-4-phenyl- 1508-90-3
Coumarin, 7-hydroxy-3-(p-methoxyphenyl)-4-phenyl-,acetate (ester) 1508-88-9
Coumarin, 6-hydroxy-4-methyl- 1508-88-9
Coumarin, 7-hydroxy-4-methyl- 90-33-5
Coumarin, 7-hydroxy-4-methyl-, bis(2-chloroethyl)phosphate 4394-77-8
Coumarin, 7-hydroxy-4-methyl-, diethylphosphate 897-83-6
Coumarin, 7-hydroxy-4-methyl-, O-ester withO,O-diethyl phosphorothioate 299-45-6
Clove oil, bud 8000-34-8
Coumarin, 7-hydroxy-4-methyl-8-(piperidinomethyl)-,hydrochloride 10550-19-3
Coumarin,7-hydroxy-4-methyl-8-(piperidinomethyl)-4-methyl-,isonicotinate (salt) 10550-22-8
Coumarin, 7-hydroxy-4-methyl-8-(piperidinomethyl)-,nicotinate (salt) 10550-20-6
Coumarin, 7-hydroxy-4-methyl-8-(piperidinomethyl)-,picolinate (salt) 10550-23-9
Coumarin, 7-hydroxy-4-methyl-3-(3-pyridyl)- 10550-23-9
Coumarin, 7-hydroxy-4-methyl-3-(3-pyridyl)-,hydrochloride 67210-68-8
Coumarin, 7-hydroxy-4-methyl-, sodium salt 5980-33-6
Coumarin, 4-hydroxy-3-(morpholinocarbonyl)- 19225-07-1

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