*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : GN7000000
CHEMICAL NAME : Coumarin, 7-hydroxy-4-methyl-
CAS REGISTRY NUMBER : 90-33-5
BEILSTEIN REFERENCE NO. : 0142217
REFERENCE : 5-18-01-00439 (Beilstein Handbook Reference)
LAST UPDATED : 199710
DATA ITEMS CITED : 15
MOLECULAR FORMULA : C10-H8-O3
MOLECULAR WEIGHT : 176.18
WISWESSER LINE NOTATION : T66 BOVJ E1 IQ
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
SYNONYMS/TRADE NAMES :
* 2H-1-Benzopyran, 7-hydroxy-4-methyl-2-oxo-
* 2H-1-Benzopyren-2-one, 7-hydroxy-4-methyl-
* Bilcolic
* Bilicante
* Cantabilin
* Cantabiline
* Coumarin 4
* Eurogale
* 7-Hydroxy-4-methylcoumarin
* 7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran
* Hymecromon
* Hymecromone
* Imecromone
* LM 94
* Medilla
* Mendiaxon
* 4-Methyl-7-hydroxycoumarin
* 4-Methylumbelliferon
* beta-Methylumbelliferone
* 4-Methylumbelliferone
* Omega 127
* Pilot 447
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3850 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Sense Organs and Special Senses (Eye) - ptosis
Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 5,1619,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2550 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Sense Organs and Special Senses (Eye) - ptosis
Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 5,1619,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 7200 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Skin and Appendages - hair
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 5,1619,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2850 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Sense Organs and Special Senses (Eye) - ptosis
Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 5,1619,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New
York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year:
21,555,1958
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >10 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Skin and Appendages - hair
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 5,1619,1971
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 56 gm/kg/4W-C
TOXIC EFFECTS :
Liver - changes in liver weight
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 4,1001,1970
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 182 gm/kg/26W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in pituitary weight
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 4,1001,1970
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 6 gm/kg
SEX/DURATION : female 9-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
GNRIDX Gendai no Rinsho. (Tokyo, Japan) V.1-10, 1967-76(?).
Volume(issue)/page/year: 4,413,1970
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 6 gm/kg
SEX/DURATION : female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
GNRIDX Gendai no Rinsho. (Tokyo, Japan) V.1-10, 1967-76(?).
Volume(issue)/page/year: 4,403,1970
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 1500 mg/kg
SEX/DURATION : female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth
REFERENCE :
GNRIDX Gendai no Rinsho. (Tokyo, Japan) V.1-10, 1967-76(?).
Volume(issue)/page/year: 4,403,1970
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X7017
No. of Facilities: 25 (estimated)
No. of Industries: 2
No. of Occupations: 4
No. of Employees: 2001 (estimated)
No. of Female Employees: 395 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Coumarin, 7-(3-(dimethylamino)propoxy)-3-(4-pyridyl)-
| 5913-19-9 |
Coumarin, 4,7-dimethyl-5-hydroxy-
| 6335-27-9 |
Coumarin, 4,6-dimethyl-7-methylamino-
| 26078-24-0 |
Coumarin, 8-((3,7-dimethyl-2-octenyl)oxy)-7-hydroxy-
| 98299-78-6 |
Coumarin, 3-(2,3-dimethylphenyl)-4-hydroxy-
| 73791-09-0 |
Coumarin, 3-(2,4-dimethylphenyl)-4-hydroxy-
| 73791-10-3 |
Coumarin, 3-(2,5-dimethylphenyl)-4-hydroxy-
| 73791-11-4 |
Clostomycin D
| 106008-72-4 |
Coumarin, 3-(2,6-dimethylphenyl)-4-hydroxy-
| 73791-12-5 |
Coumarin, 3-(3,4-dimethylphenyl)-4-hydroxy-
| 73791-13-6 |
Coumarin, 3-(3,5-dimethylphenyl)-4-hydroxy-
| 15301-97-0 |
Coumarin, 3,4-diphenyl-7-hydroxy-, acetate (ester)
| 1508-89-0 |
Coumarin,3-((2-(dipropylamino)ethyl)carbamoyl)-4-hydroxy-8-methyl-, monohydrochloride
| 19225-12-8 |
Coumarin, 4-dipropylamino-3-nitro-
| 50527-32-7 |
Coumarin, 3-ethyl-
| 66898-39-3 |
Coumarin, 3-(alpha-ethylbenzyl)-4-hydroxy-
| 435-97-2 |
Coumarin, 4-ethyl-7-hydroxy-3-(p-methoxyphenyl)-
| 5219-17-0 |
Coumarin, 3-(o-ethylphenyl)-4-hydroxy-
| 73791-14-7 |
Clostridium butyricum miyairi, powder
| 73791-14-7 |
Coumarin, 3-glyoxyloyl-
| 91635-05-1 |
Coumarin, 3-glyoxyloyl-8-methoxy-
| 92024-91-4 |
Coumarin, 3-hydroxy-
| 939-19-5 |
Coumarin, 7-hydroxy-
| 93-35-6 |
Coumarin, 4-hydroxy-3-(alpha-(2-hydroxyallyl)benzyl)-
| 101468-14-8 |
Coumarin, 4-hydroxy-3-((2-hydroxy-1-naphthyl)methyl)-
| 19225-16-2 |
Coumarin, 7-hydroxy-3-(p-hydroxyphenyl)-4-phenyl-
| 100242-24-8 |
Coumarin, 4-hydroxy-6-iodo-3-(1-naphthyl-3-oxobutyl)-
| 13021-90-4 |
Coumarin,6-(2-hydroxy-3-isobutylaminopropoxy)-7-methoxy-4-methyl-, hydrochloride
| 63446-03-7 |
Coumarin,7-(2-hydroxy-3-isobutylaminopropoxy)-6-methoxy-4-methyl-, hydrochloride
| 63446-02-6 |
Citric acid, yttrium salt (31)
| 63938-20-5 |
Clove oil, leaf
| 8000-34-8 |
Coumarin, 4-hydroxy-3-(o-isopropylphenyl)-
| 73791-15-8 |
Coumarin, 7-hydroxy-6-methoxy-
| 92-61-5 |
Coumarin, 7-hydroxy-6-methoxy-3,7'-oxydi-
| 2034-69-7 |
Coumarin, 7-hydroxy-3-(p-methoxyphenyl)-4-phenyl-
| 1508-90-3 |
Coumarin, 7-hydroxy-3-(p-methoxyphenyl)-4-phenyl-,acetate (ester)
| 1508-88-9 |
Coumarin, 6-hydroxy-4-methyl-
| 1508-88-9 |
Coumarin, 7-hydroxy-4-methyl-
| 90-33-5 |
Coumarin, 7-hydroxy-4-methyl-, bis(2-chloroethyl)phosphate
| 4394-77-8 |
Coumarin, 7-hydroxy-4-methyl-, diethylphosphate
| 897-83-6 |
Coumarin, 7-hydroxy-4-methyl-, O-ester withO,O-diethyl phosphorothioate
| 299-45-6 |
Clove oil, bud
| 8000-34-8 |
Coumarin, 7-hydroxy-4-methyl-8-(piperidinomethyl)-,hydrochloride
| 10550-19-3 |
Coumarin,7-hydroxy-4-methyl-8-(piperidinomethyl)-4-methyl-,isonicotinate (salt)
| 10550-22-8 |
Coumarin, 7-hydroxy-4-methyl-8-(piperidinomethyl)-,nicotinate (salt)
| 10550-20-6 |
Coumarin, 7-hydroxy-4-methyl-8-(piperidinomethyl)-,picolinate (salt)
| 10550-23-9 |
Coumarin, 7-hydroxy-4-methyl-3-(3-pyridyl)-
| 10550-23-9 |
Coumarin, 7-hydroxy-4-methyl-3-(3-pyridyl)-,hydrochloride
| 67210-68-8 |
Coumarin, 7-hydroxy-4-methyl-, sodium salt
| 5980-33-6 |
Coumarin, 4-hydroxy-3-(morpholinocarbonyl)-
| 19225-07-1 |
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