*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : GW4600000
CHEMICAL NAME : 1-Cyclohexene-1-carboxylic acid, 3,4,5-trihydroxy-
CAS REGISTRY NUMBER : 138-59-0
LAST UPDATED : 199510
DATA ITEMS CITED : 11
MOLECULAR FORMULA : C7-H10-O5
MOLECULAR WEIGHT : 174.17
WISWESSER LINE NOTATION : L6UTJ AVQ CQ DQ EQ
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Natural Product
SYNONYMS/TRADE NAMES :
* Bracken fern toxic component
* Shikimate
* Shikimic acid
* 3,4,5-Trihydroxy-1-cyclohexene-1-carboxylic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
V.1- 1869- Volume(issue)/page/year: 250,348,1974
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4000 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - tumors
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
V.1- 1869- Volume(issue)/page/year: 250,348,1974
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 40 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - tumors
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
V.1- 1869- Volume(issue)/page/year: 250,348,1974
** MUTATION DATA **
TYPE OF TEST : Dominant lethal test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 1000 mg/kg
REFERENCE :
BJLSAF Botanical Journal of the Linnean Society. (Academic Press, Inc., 1
E. First St., Duluth, MN 55802) V.62- 1969- Volume(issue)/page/year:
73,105,1976
TYPE OF TEST : Dominant lethal test
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 3200 mg/kg
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
V.1- 1869- Volume(issue)/page/year: 250,348,1974
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - hamster Kidney
DOSE/DURATION : 250 mg/L
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 19,43,1983
*** REVIEWS ***
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 40,47,1986
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 40,47,1986
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987
TOXICOLOGY REVIEW
CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For
publisher information, see JNCIEQ. Volume(issue)/page/year: 60,1171,1976
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
1-Cyclohexene-1-carboxylic acid,2-((5-phenyl-1,3,4-thiadiazol-2-yl)amino)-
| 160893-97-0 |
3-Cyclohexene-1-carboxylic acid, 6-(trichloroacetyl)-
| 73839-57-3 |
1-Cyclohexene-1-carboxylic acid, 3,4,5-trihydroxy-
| 138-59-0 |
Cyclohexene, 3-chloro-
| 2441-97-6 |
Cyclohexene, decafluoro-
| 355-75-9 |
Cyclohexanecarboxamide,1-phenyl-N-(4-piperidino-2-butynyl)-,monohydrochloride, hydrate
| 16795-59-8 |
2-Cyclohexene-1,4-diaminium,5,6-bis(acetyloxy)-N,N,N,N',N',N'-hexamethyl-,diiodide, (1-alpha,2-beta,3-alpha,6-beta)-
| 137866-77-4 |
Cyclohexene-1,2-dicarboximide
| 27813-21-4 |
1-Cyclohexene-1,2-dicarboximide
| 4720-86-9 |
4-Cyclohexene-1,2-dicarboximide
| 85-40-5 |
4-Cyclohexene-1,2-dicarboximide, N-(2-benzoylethyl)-
| 85-40-5 |
4-Cyclohexene-1,2-dicarboximide, N-butyl-
| 2021-19-4 |
4-Cyclohexene-1,2-dicarboximide,4,5-dimethyl-N-phenacyl-
| 2021-19-4 |
4-Cyclohexene-1,2-dicarboximide,N-(2,6-dioxo-3-piperidyl)-
| 69352-90-5 |
1-Cyclohexene-1,2-dicarboximide, N-methyl-
| 28839-49-8 |
4-Cyclohexene-1,2-dicarboximide, N-methyl-
| 2021-21-8 |
Cyclohexanecarboxamide,1-phenyl-N-(4-(1-pyrrolidinyl)-2-butynyl)-,monohydrochloride, hydrate
| 16795-58-7 |
4-Cyclohexene-1,2-dicarboximide,N-(3-(4-methyl-1-piperazinyl)propyl)-, (Z)-
| 73839-58-4 |
4-Cyclohexene-1,2-dicarboximide,N-(3-morpholinopropyl)-, (Z)-
| 73825-63-5 |
4-Cyclohexene-1,2-dicarboximide,N-((1,1,2,2-tetrachloroethyl)thio)-
| 2425-06-1 |
4-Cyclohexene-1,2-dicarboximide,N-((1,1,2,2-tetrachloroethyl)thio)-, cis-
| 2939-80-2 |
4-Cyclohexene-1,2-dicarboximide,N-((1,1,2,2-tetrachloroethyl)thio)-, mixed with zincand copper
| 75045-72-6 |
4-Cyclohexene-1,2-dicarboximide,N-(trichloromethyl)thio-
| 133-06-2 |
Cyclohexene-1,2-dicarboxylic acid, bis(2-ethylhexyl)ester
| 1330-92-3 |
Cyclohexene-1,2-dicarboxylic acid,bis(2,4-hexadienyl) ester
| 1330-92-3 |
4-Cyclohexene-1,2-dicarboxylic acid,bis(2-isocyanatoethyl) ester
| 15481-65-9 |
4-Cyclohexene-1,2-dicarboxylic acid, diallyl ester
| 7495-85-4 |
Cyclohexanecarboxamide,N-(1,2,3,4-tetrahydro-2-methylisoquinolin-5-yl)-
| 41957-26-0 |
4-Cyclohexene-1,2-dicarboxylic acid, didecyl ester,mixed isomers
| 41957-26-0 |
4-Cyclohexene-1,2-dicarboxylic acid, diisodecyl ester
| 41957-26-0 |
1-Cyclohexene-1,2-dicarboxylic acid, dimethyl ester
| 4336-19-0 |
4-Cyclohexene-1,2-dicarboxylic acid, dimethyl ester
| 7500-55-2 |
1-Cyclohexene-1,2-dicarboxylic acid, dioctyl ester
| 7500-55-2 |
1-Cyclohexene-3,4-dicarboxylic acid, dioctyl ester
| 7500-55-2 |
1-Cyclohexene-1,2-dicarboxylic acid,mono(1-((4-(aminocarbonyl)-1-piperidinyl)methyl)-2-(2-(2-phenylethyl)pheno xy)ethyl) ester
| 7500-55-2 |
4-Cyclohexene-1,2-dicarboxylic acid,mono(1-((4-(aminocarbonyl)-1-piperidinyl)methyl)-2-(2-(2-phenylethyl)pheno xy)ethyl) ester
| 7500-55-2 |
1-Cyclohexene-1,2-dicarboxylic acid,mono(1-((diethylamino)methyl)-2-(2-(2-phenylethyl)phenoxy)ethyl) ester
| 7500-55-2 |
4-Cyclohexene-1,2-dicarboxylic acid,mono(1-((diethylamino)methyl)-2-(2-(2-phenylethyl)phenoxy)ethyl) ester
| 7500-55-2 |
1,4-Cyclohexanebis(methylamine), N,N'-diheptyl-,dihydrochloride, (E)-
| 1241-27-6 |
Cyclohexanecarboxamide, 1-(3-thienyl)-
| 73812-25-6 |
1-Cyclohexene-1,2-dicarboxylic acid,mono(1-((dimethylamino)methyl)-2-(2-(2-phenylethyl)phenoxy)ethyl) ester, hydrochloride
| 73812-25-6 |
4-Cyclohexene-1,2-dicarboxylic acid,mono(1-((dimethylamino)methyl)-2-(2-(2-phenylethyl)phenoxy)ethyl) ester, hydrochloride
| 86819-24-1 |
4-Cyclohexene-1,2-dicarboxylic acid,mono(1-((4-methyl-1-piperazinyl)methyl)-2-(2-(2-phenylethyl)phenoxy)ethyl) ester
| 86819-24-1 |
1-Cyclohexene-1,2-dicarboxylic acid,mono(1-((4-methyl-1-piperidinyl)methyl)-2-(2-(2-phenylethyl)phenoxy)ethyl) ester
| 86819-24-1 |
4-Cyclohexene-1,2-dicarboxylic acid,mono(1-((4-methyl-1-piperidinyl)methyl)-2-(2-(2-phenylethyl)phenoxy)ethyl) ester
| 86819-24-1 |
1-Cyclohexene-1,2-dicarboxylic acid,mono(1-((2-(2-phenylethyl)phenoxy)methyl)-2-(1-piperidinyl)ethyl) ester
| 86819-24-1 |
4-Cyclohexene-1,2-dicarboxylic acid,mono(1-((2-(2-phenylethyl)phenoxy)methyl)-2-(1-piperidinyl)ethyl) ester
| 86819-24-1 |
1-Cyclohexene-1,2-dicarboxylic acid,mono(1-((2-(2-phenylethyl)phenoxy)methyl)-2-(1-pyrrolidinyl)ethyl) ester
| 86819-24-1 |
4-Cyclohexene-1,2-dicarboxylic acid,mono(1-((2-(2-phenylethyl)phenoxy)methyl)-2-(1-pyrrolidinyl)ethyl) ester
| 86819-24-1 |
1-Cyclohexene-1,2-dicarboxylic acid,mono(1-((4-methyl-1-piperazinyl)methyl)-2-(2-(2-phenylethyl)phenoxy)ethyl) ester
| 86819-24-1 |
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