MSDS   : 5H-Dibenz(b,f)azepine,
5-(3-(dimethylamino)propyl)-10,11-dihydro-, 5-oxide,
monohydrochloride
CAS   : 19864-71-2 SYNONYMS   : * Imipramine-N-oxide hydrochloride
* Imiprex
*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : HO2275000
CHEMICAL NAME : 5H-Dibenz(b,f)azepine,
5-(3-(dimethylamino)propyl)-10,11-dihydro-, 5-oxide,
monohydrochloride
CAS REGISTRY NUMBER : 19864-71-2
LAST UPDATED : 199609
DATA ITEMS CITED : 10
MOLECULAR FORMULA : C19-H24-N2-O.Cl-H
MOLECULAR WEIGHT : 332.91
WISWESSER LINE NOTATION : T C676 BK&T&J BO B3N1&1 &GH
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Imipramine-N-oxide hydrochloride
* Imiprex
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 770 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 11,601,1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 90 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9,
Washington, DC 20231) Volume(issue)/page/year: #3574852
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 260 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 11,601,1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 640 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 11,601,1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9,
Washington, DC 20231) Volume(issue)/page/year: #3574852
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 255 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 11,601,1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 86 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 11,601,1976
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1500 mg/kg/30D-C
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in thymus weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 11,601,1976
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 5460 mg/kg/26W-C
TOXIC EFFECTS :
Endocrine - changes in thymus weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Related to Chronic Data - death
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 11,601,1976
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE : 240 mg/kg
SEX/DURATION : female 3-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
20,186,1963
*** END OF RECORD ***
ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAME CAS
5H-Dibenz(b,f)azepine,10,11-dihydro-5-(3-morpholinopropionyl)-
18300-60-2
5H-Dibenz(b,f)azepine,10,11-dihydro-5-(3-morpholinopropyl)-
18300-60-2
3,8-Diazabicyclo(3.2.1)octane,3-methyl-8-((2'-nitrothien-5'-yl)vinyl)carbonyl-
57269-49-5
3,7a-Diazacyclohepta(jk)fluoren-7(1H)-one,2,3,3a,4,5,6-hexahydro-10-chloro-3-(phenylmethyl)-,(+-)-, monomethanesulfonate
87255-61-6
5H-Dibenz(b,e)azepine,6,11-dihydro-5-(4-morpholinylacetyl)-,monohydrochloride
70337-07-4
5H-Dibenz(c,e)azepine, 6,7-dihydro-6-phenethyl-
53873-58-8
5H-Dibenz(b,f)azepine,10,11-dihydro-5-(3-(4-piperidino-4-carbamoylpiperidino)propyl)-
5942-95-0
5H-Dibenz(b,f)azepine,10,11-dihydro-5-(2-piperidinoethyl)-,monohydrochloride
5942-95-0
5H-Dibenz(b,f)azepine,10,11-dihydro-5-(m-(piperidinomethyl)benzoyl)-,hydrochloride
5942-95-0
5H-Dibenz(b,f)azepine,10,11-dihydro-5-(o-(piperidinomethyl)benzoyl)-,hydrochloride
5942-95-0
5H-Dibenz(b,f)azepine,10,11-dihydro-5-(p-(piperidinomethyl)benzoyl)-,hydrochloride
5942-95-0
5H-Dibenz(b,f)azepine,10,11-dihydro-5-(3-(4-piperidinopiperidino)propyl)-,dihydrochloride
28028-19-5
5H-Dibenz(b,f)azepine,10,11-dihydro-5-(3-piperidinopropionyl)-
26082-81-5
5H-Dibenz(b,f)azepine,10,11-dihydro-5-(3-piperidinopropyl)-
26082-81-5
3,7a-Diazacyclohepta(jk)fluoren-7(1H)-one,2,3,3a,4,5,6-hexahydro-5,5-dimethyl-3-(phenylmethyl)-, (+-)-, (Z)-2-butenedioate (1:1)
87255-56-9
5H-Dibenz(b,e)azepine,6,11-dihydro-5-(1-piperidinylacetyl)-,monohydrochloride
70337-06-3
5H-Dibenz(b,f)azepine,10,11-dihydro-2-(1-piperidinylmethyl)-
64097-56-9
5H-Dibenz(c,e)azepine, 6,7-dihydro-6-(2-propenyl)-,hydrochloride
65-15-6
5H-Dibenz(c,e)azepine, 6,7-dihydro-6-propyl-
58335-95-8
5H-Dibenz(c,e)azepine, 6,7-dihydro-6-(2-propynyl)-,hydrochloride
51839-51-1
5H-Dibenz(b,e)azepine,6,11-dihydro-5-(1-pyrrolidinylacetyl)-,monohydrochloride
70337-09-6
5H-Dibenz(b,f)azepine,10,11-dihydro-5-(2-(1-pyrrolidinyl)ethyl)-,monohydrochloride
70337-09-6
5H-Dibenz(b,f)azepine,10,11-dihydro-2-(1-pyrrolidinylmethyl)-
64097-59-2
5H-Dibenz(b,f)azepine,10,11-dihydro-5-(m-(1-pyrrolidinylmethyl)benzoyl)-,hydrochloride
64097-59-2
5H-Dibenz(b,f)azepine,10,11-dihydro-5-(o-(1-pyrrolidinylmethyl)benzoyl)-,hydrochloride
64097-59-2
3,7a-Diazacyclohepta(jk)fluoren-7(1H)-one,2,3,3a,4,5,6-hexahydro-6,6-dimethyl-3-(phenylmethyl)-, (+-)-, (Z)-2-butenedioate (1:1)
87255-69-4
5H-Dibenz(b,f)azepine,10,11-dihydro-5-(p-(1-pyrrolidinylmethyl)benzoyl)-,hydrochloride
87255-69-4
5H-Dibenz(b,f)azepine, 10-(2-(dimethylamino)ethyl)-
41972-85-4
5H-Dibenz(b,f)azepine,10-(2-(dimethylamino)ethyl)-5-ethyl-
84142-15-4
5H-Dibenz(b,f)azepine,10-(2-(dimethylamino)ethyl)-8-(ethylsulfonyl)-5-methyl-, hydrochloride
52813-92-0
5H-Dibenz(b,f)azepine,10-(2-(dimethylamino)ethyl)-8-(ethylthio)-5-methyl-,hydrochloride
52813-90-8
5H-Dibenz(b,f)azepine,10-(2-(dimethylamino)ethyl)-5-methyl-
30490-51-8
5H-Dibenz(b,f)azepine, 10-(2-(dimethylamino)ethyl)-,oxalate
101607-50-5
5H-Dibenz(b,f)azepine,5-(2'-(N,N-dimethylamino)-2'-methyl)ethyl-
63918-76-3
5H-Dibenz(b,f)azepine,10-(dimethylaminomethyl)-5-methyl-, hydrochloride
28941-77-7
5H-Dibenz(b,f)azepine,5-(3-(dimethylamino)-2-methylpropyl)-10,11-dihydro-
739-71-9
3,7a-Diazacyclohepta(jk)fluoren-7(1H)-one,2,3,3a,4,5,6-hexahydro-6,6-dimethyl-, (+-)-,(Z)-2-butenedioate (1:1)
87255-66-1
5H-Dibenz(b,f)azepine,5-(3-(dimethylamino)-2-methylpropyl)-10,11-dihydro-,(-)-
3564-75-8
5H-Dibenz(b,f)azepine,5-(3-(dimethylamino)-2-methylpropyl)-10,11-dihydro-,(+)-
3564-66-7
5H-Dibenz(b,f)azepine, 5-(3-(dimethylamino)propyl)-
303-54-8
5H-Dibenz(b,f)azepine,5-(3-(dimethylamino)propyl)-10,11-dihydro-
50-49-7
5H-Dibenz(b,f)azepine,5-(3-(dimethylamino)propyl)-10,11-dihydro-, and3H-1,4- benzodiazepine,7-chloro-2-(methylamino)-5-phenyl-, 4-oxide (2:1)
63918-77-4
5H-Dibenz(b,f)azepine,5-(3-(dimethylamino)propyl)-10,11-dihydro-, and2-((p-chlorobenzyl)(2-(dimethylamino)ethyl)amino)pyridine (1:1)
63918-77-4
5H-Dibenz(b,f)azepine,5-(3-(dimethylamino)propyl)-10,11-dihydro- mixed withethyl alcoholSUBSTANCE DEFINITION :94% 5H-Dibenz(b,f)azepine,5-(3-(dimethylamino)propyl)-10,11-dihydro-:6%ethyl alcoholREFERENCE :AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (HeymansInstitute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-1898- Volume(issue)/page/year: 148,560,1964
63918-77-4
5H-Dibenz(b,f)azepine,5-(3-(dimethylamino)propyl)-10,11-dihydro-,monohydrochloride
113-52-0
5H-Dibenz(b,f)azepine,5-(3-(dimethylamino)propyl)-10,11-dihydro-, 5-oxide
2207-85-4
5H-Dibenz(b,f)azepine,5-(3-(dimethylamino)propyl)-10,11-dihydro-, 5-oxide,monohydrochloride
19864-71-2
3,7a-Diazacyclohepta(jk)fluoren-7(1H)-one,2,3,3a,4,5,6-hexahydro-5,5-dimethyl-, (+-)-,(Z)-2-butenedioate (1:1)
87255-59-2
5H-Dibenz(b,f)azepine,5-(3-(dimethylamino)propyl)-10,11-dihydro-, mixedwith sodium nitrite (1:4)
87255-59-2
5H-Dibenz(b,f)azepine, 5-(3-(dimethylamino)propyl)-,fumarate
72629-48-2