*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : HY4025000
CHEMICAL NAME : Dicyclohexylamine
CAS REGISTRY NUMBER : 101-83-7
BEILSTEIN REFERENCE NO. : 0605923
REFERENCE : 4-12-00-00022 (Beilstein Handbook Reference)
LAST UPDATED : 199710
DATA ITEMS CITED : 18
MOLECULAR FORMULA : C12-H23-N
MOLECULAR WEIGHT : 181.36
WISWESSER LINE NOTATION : L6TJ AM- AL6TJ
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* N-Cyclohexylcyclohexanamine
* DCHA
* Dicha
* N,N-Diclohexylamine
* Dicyklohexylamin
* Dodecahydrodiphenylamine
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 2 mg/24H
REACTION SEVERITY : Severe
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,468,1986
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 750 ug/24H
REACTION SEVERITY : Severe
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,468,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 373 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,468,1986
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,468,1986
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 135 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.1- 1955- Volume(issue)/page/year: 4,659,1958
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
IECHAD Industrial and Engineering Chemistry. (Washington, DC) V.15-62,
1923-70. For publisher information, see CHMTBL. Volume(issue)/page/year:
29,1247,1937
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 40 gm/kg/52W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - tumors
Liver - tumors
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.1- 1955- Volume(issue)/page/year: 4,659,1958
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2404 mg/kg/48W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.1- 1955- Volume(issue)/page/year: 4,659,1958
** MUTATION DATA **
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Leukocyte
DOSE/DURATION : 200 ug/L
REFERENCE :
INHEAO Industrial Health. (National Institute of Industrial Health, 6-21-1
Nagao, Tama-ku, Kawasaki, 213 Japan) V.1- 1963- Volume(issue)/page/year:
9,188,1971
*** REVIEWS ***
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 22,55,1980
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 22,55,1980
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,178,1987
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M1151
No. of Facilities: 60 (estimated)
No. of Industries: 3
No. of Occupations: 3
No. of Employees: 368 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M1151
No. of Facilities: 40 (estimated)
No. of Industries: 2
No. of Occupations: 3
No. of Employees: 3412 (estimated)
No. of Female Employees: 169 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9219;8EHQ-0892-9270
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Dicarbonic acid SK 64
| 4525-33-1 |
Diccliptera roxburghiana Nees, extractSUBSTANCE DEFINITION :Plant belonging to the family AcanthaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 16,228,1978
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Dicentera macrocapnos Prain, extractSUBSTANCE DEFINITION :Plant belonging to the family PapaveraceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 18,594,1980
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Dichapetalum andamanicum King, extractSUBSTANCE DEFINITION :Plant belonging to the family DichapetalaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 28,619,1990
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Dichapetalum gelonioides (Roxb.)Engl., extractSUBSTANCE DEFINITION :Plant belonging to the family DichapetalaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 28,619,1990
| 4525-33-1 |
Dichroa febrifuga Lour., extract excluding rootsSUBSTANCE DEFINITION :Plant belonging to the family SaxifragaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 4525-33-1 |
11H-Dibenzo(b,e)(1,4)diazepin-11-one,5,10-dihydro-5-(2-(diethylamino)ethyl)-, N-oxide
| 2137-28-2 |
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| 2137-28-2 |
alpha-Dichroine
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gamma-Dichroine
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Dichromic acid, calcium salt (11)
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Dichromic acid, diammonium salt
| 7789-09-5 |
Dichromic acid, dipotassium salt
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Dichromic acid, disodium salt
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Dichromic acid (H2Cr2O7), disodium salt, dihydrate
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Dichromic acid, zinc salt (11)
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Dichrostachys cineria Wight & Arn., extract excludingrootsSUBSTANCE DEFINITION :Plant belonging to the family LeguminosaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 14018-95-2 |
11H-Dibenzo(b,e)(1,4)diazepin-11-one,5,10-dihydro-5-(3-(diethylamino)propyl)-
| 13961-22-3 |
Dickson color 4CSUBSTANCE DEFINITION :Commercial hairdye product from Milan, ItalyREFERENCE :FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House,Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year:20,171,1982
| 13961-22-3 |
Dickson color 6CSUBSTANCE DEFINITION :Commercial hairdye product from Milan, ItalyREFERENCE :FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House,Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year:20,171,1982
| 13961-22-3 |
Dickson color 8CSUBSTANCE DEFINITION :Commercial hairdye product from Milan, ItalyREFERENCE :FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House,Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year:20,171,1982
| 13961-22-3 |
Dictamni radicis cortex extractSUBSTANCE DEFINITION :Chinese crude drugREFERENCE :YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881-Volume(issue)/page/year: 102,596,1982
| 13961-22-3 |
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Dicyclohexylamine
| 101-83-7 |
Dicyclohexylamine, acetate
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Dicyclohexylamine, N-(2-chloroethyl)-, hydrochloride
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Dicyclohexylamine, N-(2,3-dichloropropyl)-,hydrochloride
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Dicyclohexylamine, N-ethyl-
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11H-Dibenzo(b,e)(1,4)diazepin-11-one,5,10-dihydro-10-(3-(diethylamino)propyl)-
| 4231-97-4 |
Dicyclohexylamine, N-methyl-
| 7560-83-0 |
Dicyclohexylamine, nitrate
| 3882-06-2 |
Dicyclohexylamine, nitrite
| 3129-91-7 |
Dicyclohexylamine, N-nitroso-
| 947-92-2 |
Dicyclopenta(a,d)cyclooctene-3,4-diol,1,2,3,3a,4,5,7,8,9,9a,10,10a-dodecahydro-4,9a-dimethyl-1-(hydroxymethyl)-7-(1-methylethyl)-
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Dicyclopenta(a,f)naphthalene-2-beta,7-beta-diol,hexadecahydro-2-alpha,7-alpha-diethynyl-8a,10a-dimethyl-
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Dicyclopenta(a,def)phenanthren-6(4H)-one, 7,8-dihydro(9CI)
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Dicyclopentapyrazine, 1,2,3,5,6,7-hexahydro-1,5(or7)-dimethyl-
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Dicyclopenta(b,e)pyridine,1,2,3,5,6,7-hexahydro-8-amino-, hydrate
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Dicyclopropanecarboxamide
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11H-Dibenzo(b,e)(1,4)diazepin-11-one,5,10-dihydro-5-(3-(diethylamino)propyl)-, N-oxide
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Didymium nitrate
| 33662-62-3 |
Dieffenbachia amoena Gentil, leaf or stem extract
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Dieffenbachia bausei Regel, leaf extract
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Dieffenbachia picta, juice extract
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Dieffenbachia picta Schott, extract
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Dieffenbachia seguina (L.) Schott, var. viridisengl., extract
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