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MSDS  : 1,7-Dicarbacalcitonin (salmon), 1-butanoic acid-26-L-aspartic acid-27-L-valine-29-L-alanine-
CAS  : 60731-46-6
SYNONYMS  : * (Aminosuberic acid 1,7)-eel calcitonin * Carbocalcitonin * Elcatonin * HC-58
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : HS9270000
CHEMICAL NAME : 1,7-Dicarbacalcitonin (salmon), 1-butanoic
acid-26-L-aspartic acid-27-L-valine-29-L-alanine-
CAS REGISTRY NUMBER : 60731-46-6
LAST UPDATED : 199406
DATA ITEMS CITED : 10
MOLECULAR FORMULA : C148-H244-N42-O47
MOLECULAR WEIGHT : 3364.34
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* (Aminosuberic acid 1,7)-eel calcitonin
* Carbocalcitonin
* Elcatonin
* HC-58

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >185 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,921,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >185 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,921,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >185 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,921,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >185 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,921,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >338 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,921,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >338 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,921,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >338 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,921,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >338 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,921,1982

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 18 ku/kg/26W-C
TOXIC EFFECTS :
Liver - other changes
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 19,915,1985

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 2240 units/kg/4W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - urine volume decreased
Kidney, Ureter, Bladder - other changes in urine composition
Nutritional and Gross Metabolic - changes in calcium
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 21,4477,1993

*** END OF RECORD ***
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NAMECAS
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Dibutylamine, N-nitroso-4,4,4-trifluoro- 83329-15-1
Dibutylamine, N-(3-(p-(phenoxymethyl)phenyl)propyl)- 101198-08-7
Dibutylamine, tetrafluoroborate(1-) 12107-76-5
Dibutylamine, N-(2-(triethylsiloxy)ethyl)- 20467-04-3
Dibutylamine, N-(2-(trimethylsiloxy)ethyl)- 17048-36-1
Dibutyl phosphite 1809-19-4
Dibutyramide,N-(2,3,6,7-tetrahydro-1H,5H-benzo(ij)quinolizin-9-yl)- 101198-09-8
1,7-Dicarbacalcitonin (salmon), 1-butanoicacid-2-L-alanine-3-L-serine-26-L-aspartic acid-27-L-valine-29-L-alanine- 103451-84-9
1,7-Dicarbacalcitonin (salmon), 1-butanoicacid-26-L-aspartic acid-27-L-valine-29-L-alanine- 60731-46-6
1,2-Dicarbadodecaboran(12)-3-amine 22043-65-8
5H-Dibenzo(b,e)(1,4)diazepin-11-one,10,11-dihydro-7-chloro-10-(2-(pyrrolidinyl)ethyl)- 22043-65-8
Dicarbadodecaborane(12) 12402-95-8
1,2-Dicarbadodecaborane(12) 16872-09-6
1,7-Dicarbadodecaborane (12) 16986-24-6
1,2-Dicarbadodecaborane(12)-1-acetic acid 20644-59-1
1,7-Dicarbadodecaborane (12),1,7-bis(chlorotetramethylphenyl)- 101198-19-0
1,7-Dicarbadodecaborane (12),1,7-bis(methoxytetramethylphenyl)- 101198-20-3
1,2-Dicarbadodecaborane(12)-1-carboxylic acid 18178-04-6
1,2-Dicarbadodecaborane(12)-1,2-dimethanol 19610-37-8
1,7-Dicarbadodecaborane(12)-1,7-dimethanol 23924-78-9
1,2-Dicarbadodecaborane(12)-1,2-dimethanol, diacetate 19610-38-9
5H-Dibenzo(a,d)cyclohepten-5-one,10-(4-(2-phenylethyl)-1-piperazinyl)- 56973-10-5
11H-Dibenzo(b,e)(1,4)diazepin-11-one,5,10-dihydro-5-(2-(diethylamino)ethyl)- 14870-41-8
1,7-Dicarbadodecaborane(12)-1,7-dimethanol, diacetate 42568-26-3
1,2-Dicarbadodecaborane(12), 1,2-diphenyl- 17805-19-5
1,2-Dicarbadodecaborane(12), 1-ethenyl- 20313-28-4
Dicarbadodecaborane(12), hexyl- 20740-05-0
1,2-Dicarbadodecaborane(12)-1-methanol 19610-34-5
1,7-Dicarbadodecaborane(12)-1-methanol 53257-04-8
1,2-Dicarbadodecaborane(12)-1-methanol, acetate 19528-60-0
1,7-Dicarbadodecaborane(12)-1-methanol, acetate 81944-35-6
1,2-Dicarbadodecaborane(12), 1-(1-methylethenyl)- 17525-52-9
1,7-Dicarbadodecaborane(12), 1-(1-methylethenyl)- 81944-36-7
11H-Dibenzo(b,e)(1,4)diazepin-11-one,5,10-dihydro-10-(2-(diethylamino)ethyl)- 4343-43-5
1,2-Dicarbadodecaborane(12), 1-(1-methylethyl)- 13569-38-5
1,7-Dicarbadodecaborane(12), 1-(1-methylethyl)- 23868-54-4
1,2-Dicarbadodecaborane(12), 1-(2-methyloxiranyl)- 12072-23-0
1,2-Dicarbadodecaborane(12), 1-phenyl- 16390-61-7
1,2-Dicarbadodecaborane(12)-1-sulfonic acid,2-methyl-, potassium salt 78683-34-8
1,2-Dicarbadodecaborane(12)-1-thiol 17526-07-7
1,2-Dicarbadodecaborane(12)-1-thiol, 2-methyl- 17522-84-8
1,2-Dicarbaundecaborane(11), potassium salt 12304-72-2
Dicarbaundecaborate(1-), dodecahydro-, potassium 39326-91-5
Dicarbaundecaborate(1-), undecahydro-6-amino-,potassium 39326-91-5
11H-Dibenzo(b,e)(1,4)diazepin-11-one,5,10-dihydro-5-(2-(diethylamino)ethyl)-10-(3-(dimethylamino)propyl)-, dihydrochloride 67195-39-5
Dicarbododecaborane, undecachloro- 30620-58-7
Dicarbonic acid, diethyl ester mixed with ammonia 30620-58-7
Dicarbonic acid, dimethyl ester 4525-33-1

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