RTECS NUMBER : KG2915000
CHEMICAL NAME : Estra-1,4-diene-3,17-dione, 10-hydroxy-, acetate
CAS REGISTRY NUMBER : 4147-12-0
LAST UPDATED : 198910
DATA ITEMS CITED : 3
MOLECULAR FORMULA : C20-H24-O4
MOLECULAR WEIGHT : 328.44
COMPOUND DESCRIPTOR : Reproductive Effector
Hormone
SYNONYMS/TRADE NAMES :
* Estra-1,4-diene-3,17-dione, 10-(acetyloxy)-
* 10-Hydroxyestra-1,4-diene-3,17-dione acetate
*** HEALTH HAZARD DATA ***
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE : 5 mg/kg
SEX/DURATION : female 1 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
REFERENCE :
85GRAA "The Control of Fertility," Pincus, G., New York, Academic Press,
1965 Volume(issue)/page/year: -,111,1965
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE : 4 mg/kg
SEX/DURATION : female 1 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
REFERENCE :
85GRAA "The Control of Fertility," Pincus, G., New York, Academic Press,
1965 Volume(issue)/page/year: -,111,1965
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rabbit
DOSE : 12500 ng/kg
SEX/DURATION : female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
REFERENCE :
85GRAA "The Control of Fertility," Pincus, G., New York, Academic Press,
1965 Volume(issue)/page/year: -,111,1965
*** END OF RECORD ***
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