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MSDS  : Glutamic acid, N-(3,5-dichloro-4-(((2,4-diamino-6-pteridinyl)methyl) methylamino)benzoyl)-
CAS  : 528-74-5
SYNONYMS  : * Amethopterin, 3',5'-dichloro- * Dichloroamethopterin * 3',5'-Dichloroamethopterin * 3',5'-Dichloro-4-amino-4-deoxy-N(sup 10)-methylpteroglutamic acid * N-(3,5-Dichloro-4-((2,4-diamino-6-pteridinylmethyl)methylamino)benzoyl)g lutamic acid * Dichloromethotrexate * 3',5'-Dichloromethotrexate * Methotrexate, dichloro- * NCI-C04875 * NSC-29630
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : MA1250000
CHEMICAL NAME : Glutamic acid,
N-(3,5-dichloro-4-(((2,4-diamino-6-pteridinyl)methyl)
methylamino)benzoyl)-
CAS REGISTRY NUMBER : 528-74-5
OTHER CAS REGISTRY NOS. : 88442-77-7
BEILSTEIN REFERENCE NO. : 0073523
REFERENCE : 4-26-00-03834 (Beilstein Handbook Reference)
LAST UPDATED : 199612
DATA ITEMS CITED : 9
MOLECULAR FORMULA : C20-H20-Cl2-N8-O5
MOLECULAR WEIGHT : 523.38
WISWESSER LINE NOTATION : T66 BN DN GN JNJ CZ EZ H1N1&R BG FG DVMYVQ2VQ
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Amethopterin, 3',5'-dichloro-
* Dichloroamethopterin
* 3',5'-Dichloroamethopterin
* 3',5'-Dichloro-4-amino-4-deoxy-N(sup 10)-methylpteroglutamic acid
* N-(3,5-Dichloro-4-((2,4-diamino-6-pteridinylmethyl)methylamino)benzoyl)g
lutamic acid
* Dichloromethotrexate
* 3',5'-Dichloromethotrexate
* Methotrexate, dichloro-
* NCI-C04875
* NSC-29630

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 655 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCISP* National Cancer Institute Screening Program Data Summary,
Developmental Therapeutics Program. (Bethesda, MD 20205)
Volume(issue)/page/year: JAN1986

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1021 mg/kg
TOXIC EFFECTS :
Behavioral - excitement
Behavioral - muscle weakness
Behavioral - ataxia
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB82-172644

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 75 mg/kg/7W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Endocrine - tumors
Endocrine - adrenal cortex tumors
REFERENCE :
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment
Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948-
Volume(issue)/page/year: 40,1935,1977

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 5850 mg/kg/26W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Endocrine - adrenal cortex tumors
REFERENCE :
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment
Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948-
Volume(issue)/page/year: 40,1935,1977

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 500 mg/kg
SEX/DURATION : female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Newborn - live birth index (measured after birth)
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
per # born alive)
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc.,
41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year:
7,7,1987

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 500 mg/kg
SEX/DURATION : female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc.,
41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year:
7,7,1987

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 1 mg/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 5(Suppl
1),3,1983

*** STATUS IN U.S. ***

NCI Carcinogenesis Studies (ipr);equivocal evidence:rat
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment
Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948-
Volume(issue)/page/year: 40,1935,77

NCI Carcinogenesis Studies (ipr);no evidence:mouse
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment
Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948-
Volume(issue)/page/year: 40,1935,77


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Glutamic acid,N-(p-(1-(2,4-diaminopyrido(3,2-d)pyrimidin-6-ylmethyl)propyl)benzoyl)-, hydrate 88393-05-9
Glutamic acid,N-(p-(((2,4-diamino-6-quinazolinyl)methyl)amino)benzoyl)-, L- 18921-68-1
Glucopyranose, polymers, complex with cobalt 18921-68-1
Glutamic acid,N-(3,5-dichloro-4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)- 528-74-5
L-Glutamic acid, N-((2,4-dichlorophenoxy)acetyl)- 32773-59-4
L-Glutamic acid, didecyl ester, hydrochloride 94856-86-7
L-Glutamic acid, didodecyl ester, hydrochloride 59441-30-4
L-Glutamic acid, diethyl ester, hydrochloride 1118-89-4
L-Glutamic acid, dihexadecyl ester,4-methylbenzenesulfonate 95992-27-1
L-Glutamic acid,N-(L-2-(5-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)tetrahydro-3,4-dihydrox y- 2-furanyl)glycyl)-,(2R-(2-alpha,3-beta,4-beta,5-alpha))- 77368-58-2
L-Glutamic acid,N-(L-2-(5-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)tetrahydro-3,4-dihydrox y-2-furanyl)-N-((3S,4S)-4-hydroxy-4-(5-hydroxy-2-pyrimidinyl)-L-valyl)glycyl )-,(2R-(2-alpha,3-beta,4-beta,5-alpha))- 77368-59-3
L-Glutamic acid,N-(4-(((1,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl)-2-propynylamino) benzoyl)- 112887-62-4
L-Glutamic acid,1-(11-beta,17-dihydroxy-3,20-dioxopregn-4-en-21-yl)ester, hydrochloride 112887-62-4
alpha-D-Glucopyranose, 2,3,4,6-tetracetate1-(phenylbis(2-chloroethyl)phosphoramide) 53115-84-7
Glutamic acid, N-(2,5-diiodobenzoyl)- 53115-84-7
Glutamic acid, compd. with 2-(dimethylamino)ethanol(1:2), L- 53115-84-7
Glutamic acid, N-(p-(3,3-dimethyltriazeno)benzoyl)-,diethyl ester, DL- 34136-24-8
L-Glutamic acid, diteradecyl ester, hydrochloride 125401-72-1
Glutamic acid, N-(dithiocarboxy)-, L-, trisodium salt 75808-54-7
Glutamic acid, N-(dithiocarboxy)-, L-, zinc salt,hydrate (2:3:2) 55127-77-0
L-Glutamic acid,N-((4-((ethoxycarbonyl)amino)phenyl)sulfonyl)-,diethyl ester 81865-27-2
L-Glutamic acid,N-((4-((ethoxycarbonyl)amino)phenyl)sulfonyl)-,dimethyl ester 81865-26-1
L-Glutamic acid,N-(L-2-(5-(4-formyl-2,3-dihydro-2-oxo-1H-imidazol-1-yl)tetrahydro- 3,4-dihydroxy-2-furanyl)glycyl)-,(2R-(2-alpha,3-beta,4-beta,5-alpha))- 77368-62-8
L-Glutamic acid,N-(L-2-(5-(4-formyl-2,3-dihydro-2-oxo-1H-imidazol-1-yl)tetrahydro-3,4-dihydroxy-2-furanyl)-((3S,4S)-4-hydroxy-4-(5-hydroxy-2-pyrimidinyl)-L- valyl)glycyl)-,(2R-(2-alpha,3-beta,4-beta,5-alpha))- 77368-60-6
Glucopyranose, 1-thio-, 1-(3-butenohydroximate)NO-(hydrogensulfate), monopotassium salt, beta-D- 3952-98-5
Glutamic acid, mixed with glucose 3952-98-5
Glutamic acid, N-glycyl-, L-, pyrolyzate 3952-98-5
Glutamic acid, N-hydrogenated tallowyl-, L-,monosodium salt 3952-98-5
L-Glutamic acid, N-(2-hydroxybenzoyl)- 3441-69-8
L-Glutamic acid, N-((5-hydroxy-3-pyridinyl)carbonyl)- 112193-35-8
Glutamic acid,5-(2-(alpha-hydroxy-p-tolyl)hydrazide), L- 2757-90-6
L-Glutamic acid, compd. with 5-hydroxy-L-tryptophan(1:1), monohydrate 60575-35-1
L-Glutamic acid, N-(3-hydroxy-L-tyrosyl)-, hydrate(2:1) 52370-53-3
Glutamic acid, N-(o-iodobenzoyl)- 52370-53-3
Glutamic acid, N-(p-iodobenzoyl)- 52370-53-3
Glucopyranose, 1-thio-, 1-hydrocinnamohydroximateNO-(hydrogen sulfate), beta-D- 499-30-9
Glutamic acid, iron (2+) salt (11) 2896-87-9
L-Glutamic acid, N-(N(sup2)-(N-(N-L-isoleucyl-L-isoleucyl)-O-phosphono-L-seryl)-L- glutaminyl)-, hydrate 90119-88-3
Glutamic acid, N-lauroyl-, L-, monosodium salt 29923-31-7
Glutamic acid, N-L-leucyl-3-nitro-, sodium salt,hemihydrate (2:2:1) 29923-31-7
Glutamic acid, magnesium salt (11), L- 64407-99-4
L-Glutamic acid, magnesium salt (11), hydrobromide 53459-38-4
Glutamic acid, N-(2-methoxynicotinoyl)- 76980-28-4
Glutamic acid, N-(p-(methylamino)benzoyl)-, sodiumsalt 76980-28-4
Glutamic acid, monoammonium salt, L- 7558-63-6
L-Glutamic acid, monoammonium salt, monohydrate 139883-82-2
Glucopyranose, 1-thio-,1-((S)-3-hydroxy-4-pentenohydroximate) NO-(hydrogensulfate), beta-D- 19237-18-4
L-Glutamic acid, monocalcium salt, tetrahydrate 69704-19-4
L-Glutamic acid, monopiperidinium salt 69704-19-4
Glutamic acid, monopotassium salt, L- 19473-49-5

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