Search   
MSDS  : 1-Adamantanamine, hydrochloride
CAS  : 665-66-7
SYNONYMS  : * Adamantanamine hydrochloride * 1-Adamantanamine hydrochloride * Adamantine hydrochloride * Adamantylamine hydrochloride * 1-Adamantylamine hydrochloride * Amantadine hydrochloride * Aminoadamantane hydrochloride * 1-Aminoadamantene hydrochloride * EXP 105-1 * Midantane * Mydantane * NSC 83653 * Symmetrel * Tricyclo(3.3.1.1(sup 3,7))decan-1-amine, hydrochloride * Virasol * Virofral
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : AU4375000
CHEMICAL NAME : 1-Adamantanamine, hydrochloride
CAS REGISTRY NUMBER : 665-66-7
LAST UPDATED : 199706
DATA ITEMS CITED : 21
MOLECULAR FORMULA : C10-H17-N.Cl-H
MOLECULAR WEIGHT : 187.74
WISWESSER LINE NOTATION : L66 B6 A B- C 1B ITJ BZ &GH
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Adamantanamine hydrochloride
* 1-Adamantanamine hydrochloride
* Adamantine hydrochloride
* Adamantylamine hydrochloride
* 1-Adamantylamine hydrochloride
* Amantadine hydrochloride
* Aminoadamantane hydrochloride
* 1-Aminoadamantene hydrochloride
* EXP 105-1
* Midantane
* Mydantane
* NSC 83653
* Symmetrel
* Tricyclo(3.3.1.1(sup 3,7))decan-1-amine, hydrochloride
* Virasol
* Virofral

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 24 mg/kg/1D-I
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions
Behavioral - excitement
REFERENCE :
AEMED3 Annals of Emergency Medicine. (American College of Emergency
Physicians, 1125 Executive Circle, Irving, TX 75038)
Volume(issue)/page/year: 19,668,1990

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Behavioral - coma
Cardiac - pulse rate increase, without fall in BP
Cardiac - pulse rate
REFERENCE :
AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New
York, NY 10022) V.1- 1946- Volume(issue)/page/year: 77,388,1984

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 13 mg/kg/5D-I
TOXIC EFFECTS :
Behavioral - euphoria
Behavioral - hallucinations, distorted perceptions
REFERENCE :
AJPSAO American Journal of Psychiatry. (American Psychiatric Assoc.,
Circulation Dept., 1400 K St., NW, Washington, DC 20005) V.78- 1921-
Volume(issue)/page/year: 143,1170,1985

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 286 mg/kg
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions
Behavioral - toxic psychosis
Behavioral - excitement
REFERENCE :
AJPSAO American Journal of Psychiatry. (American Psychiatric Assoc.,
Circulation Dept., 1400 K St., NW, Washington, DC 20005) V.78- 1921-
Volume(issue)/page/year: 145,267,1988

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 19,164,1988

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 150 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
15,642,1969

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 90 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 19,164,1988

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 700 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
15,642,1969

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 198 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 19,164,1988

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 290 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 19,164,1988

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 95 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 19,164,1988

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 37 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
15,642,1969

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 360 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
15,642,1969

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE : 182 mg/kg
SEX/DURATION : female 1-91 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
Volume(issue)/page/year: 2,607,1975

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE : 14 mg/kg
SEX/DURATION : female 4-6 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
Reproductive - Effects on Newborn - Apgar score (human only)
REFERENCE :
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year:
8,89,1994

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 1100 mg/kg
SEX/DURATION : female 5 day(s) pre-mating
female 1-6 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
17,272,1970

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 720 mg/kg
SEX/DURATION : female 9-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
GNRIDX Gendai no Rinsho. (Tokyo, Japan) V.1-10, 1967-76(?).
Volume(issue)/page/year: 4,44,1970

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 240 mg/kg
SEX/DURATION : female 9-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
GNRIDX Gendai no Rinsho. (Tokyo, Japan) V.1-10, 1967-76(?).
Volume(issue)/page/year: 4,44,1970

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 240 mg/kg
SEX/DURATION : female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
GNRIDX Gendai no Rinsho. (Tokyo, Japan) V.1-10, 1967-76(?).
Volume(issue)/page/year: 3,782,1969

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X3199
No. of Facilities: 56 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 1161 (estimated)
No. of Female Employees: 478 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY


*** END OF RECORD ***
Search More   
ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Acridine, 2-amino-6-chloro- 40505-20-2
Actinoxanthin 59680-34-1
Aculeacin 60606-49-7
Aculeacin A 58814-86-1
Aculeacin A alpha 69234-44-2
Aculeacin A gamma 69234-46-4
Aculeacin B 58814-87-2
Aculeacin C 58814-88-3
Aculeacin D 58814-89-4
Aculeacin D alpha 69234-45-3
Aculeacin D gamma 69234-47-5
Acridan,9,9-dimethyl-10-(3-(4-(1-pyrrolidinyl)piperidino)propyl)-, maleate (1:2) 28121-29-1
Acridine, 2-amino-7-chloro- 23045-20-7
Aculeacin E 58814-90-7
Aculeacin F 58814-91-8
Aculeacin G 58814-92-9
Aculeximycin 87912-51-4
Acrylamide, N,N-dimethyl- 2680-03-7
AcylglutamateSUBSTANCE DEFINITION :Consists of a sodium salt of the acyl linkage of bovine fatty acids withmonosodium L-glutamateREFERENCE :FUJAD7 Fragrance Journal. (Fureguransu Janaru Sha, c/o Okumura Bldg., 2-7-4Iidabashi, Chiyoda-Ku, Tokyo 102, Japan) 1974(?)- Volume(issue)/page/year:5,1,1977 2680-03-7
Acypetacs - zinc 2680-03-7
2-Adamantanamine, N-benzyl-, hydrochloride 52917-74-5
2-Adamantanamine, N-butyl-, hydrochloride 39234-34-9
1-Adamantanamine citrate, monohydrate 102395-13-1
Acridine, 3-amino-6-chloro- 40505-21-3
1-Adamantanamine, N,N-dimethyl- 3717-40-6
2-Adamantanamine, N,N-dimethyl-, hydrochloride 10535-34-9
1-Adamantanamine, N-ethyl- 3717-44-0
1-Adamantanamine, N-ethyl-, hydrochloride 3717-42-8
1-Adamantanamine, hydrochloride 665-66-7
2-Adamantanamine, hydrochloride 10523-68-9
1-Adamantanamine, N-isobutyl-, hydrochloride 23479-44-9
1-Adamantanamine, N-isopropyl-, hydrochloride 3667-91-2
1-Adamantanamine, N-methyl- 3717-38-2
1-Adamantanamine, N-methyl-, hydrochloride 3717-39-3
Acridine, 9-amino-2-chloro- 23250-39-7
2-Adamantanamine, N-methyl-, hydrochloride 10523-69-0
1-Adamantanamine,N-(2,2,3,3,3-pentafluoropropylidene)- 31224-44-9
1-Adamantanamine, N-propyl-, hydrochloride 3717-48-4
1-Adamantanamine, N-(2,2,2-trifluoroethylidene)- 31185-52-1
1-Adamantaneacetamide, N-(2-(diethylamino)ethyl)-,ethyl iodide 54099-14-8
1-Adamantaneacetamide, N-(3-(diethylamino)propyl)-,ethyl iodide 54099-16-0
1-Adamantaneacetamide, N-(2-(dimethylamino)ethyl)-,ethyl iodide 54099-13-7
1-Adamantaneacetamide, N-(3-(dimethylamino)propyl)-,ethyl iodide 54099-15-9
1-Adamantaneacetamide, 2-oxo- 27174-88-5
Adamantane, 1-(1-aminobutyl)-, hydrochloride 63872-79-7
Acridine, 9-amino-3-chloro- 3407-98-5
Adamantane, 1-(1-aminopentyl)-, hydrochloride 63872-80-0
Adamantane, 1-(2-aminopropyl)-, hydrochloride 39978-68-2
Adamantane, 1-(3-aminopropyl)-, hydrochloride 31897-98-0
Adamantane, 1-(2-benzylaminopropyl)-, hydrochloride 31897-90-2

Free MSDS Search ( Providing 250,000+ Material Properties )
Chemcas.com| Ads link:todaystock.net