RTECS NUMBER : MD6300000
CHEMICAL NAME : Gold sodium thiosulfate, dihydrate
CAS REGISTRY NUMBER : 10210-36-3
LAST UPDATED : 199203
DATA ITEMS CITED : 7
MOLECULAR FORMULA : O6-S4.Au.3Na.2H2-O
MOLECULAR WEIGHT : 503.23
WISWESSER LINE NOTATION : NA3 AU S2-O3*2 &QH 2
COMPOUND DESCRIPTOR : Drug
Human
SYNONYMS/TRADE NAMES :
* Auricidine
* Aurocidin
* Aurolin
* Auropex
* Auropin
* Aurosan
* Aurothion
* Crisalbine
* Novacrysin
* Sanochrysine
* Sodium aurothiosulphate dihydrate
* Solfocrisol
* Thiochrysine
* Thiosulfuric acid, gold(1+) sodium salt(2:1:3), dihydrate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Human
DOSE/DURATION : 400 ug/kg/1W
TOXIC EFFECTS :
Skin and Appendages - dermatitis, irritative (after systemic exposure)
Blood - granulocytopenia
Blood - thrombocytopenia
REFERENCE :
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200
Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year:
37,323,1952
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 35 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 49,121,1942
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 110 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JRHUA9 Journal of Rheumatology. (920 Yonge St., Suite 608, Toronto, Ont.,
Canada) V.1- 1974- Volume(issue)/page/year: 12,274,1985
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZGEMAZ Zeitschrift fuer die Gesamte Experimentelle Medizin. (Berlin, Fed.
Rep. Ger.) V.1-139, 1913-65. For publisher information, see REXMAS.
Volume(issue)/page/year: 57,77,1927
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EMSUA8 Experimental Medicine and Surgery. (Brooklyn, NY) V.1-29, 1943-71.
Suspended. Volume(issue)/page/year: 3,146,1945
*** REVIEWS ***
TOXICOLOGY REVIEW
MDCHAG Medicinal Chemistry: A Series of Monographs. (Academic Press, Inc.,
1 E. First St., Duluth, MN 55802) V.1- 1963- Volume(issue)/page/year:
13(1),209,1974
TOXICOLOGY REVIEW
PTPAD4 Pharmacology and Therapeutics, Part A: Chemotherapy, Toxicology and
Metabolic Inhibitors. (Oxford, UK) V.1-2, 1976-78. For publisher
information, see PHTHDT. Volume(issue)/page/year: 1,119,1976
*** END OF RECORD ***
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