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MSDS  : 1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-
CAS  : 458-37-7
SYNONYMS  : * C.I. 75300 * C.I. Natural Yellow 3 * Curcuma * Curcumin * Diferuloylmethane * E 100 * Golden seal * Haidr * Halad * Haldar * Halud * Hydrastis * Indian saffron * Indian turmeric * Kacha haldi * Kurkumin * Merita earth * NCI-C61325 * Orange Root * Souchet * Turmeric Yellow * Yellow ginger * Yellow puccoon * Yellow root * Yo-kin * Zlut prirodni 3
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : MI5230000
CHEMICAL NAME : 1,6-Heptadiene-3,5-dione,
1,7-bis(4-hydroxy-3-methoxyphenyl)-
CAS REGISTRY NUMBER : 458-37-7
OTHER CAS REGISTRY NOS. : 33171-04-9
BEILSTEIN REFERENCE NO. : 2306965
REFERENCE : 4-08-00-03697 (Beilstein Handbook Reference)
LAST UPDATED : 199801
DATA ITEMS CITED : 13
MOLECULAR FORMULA : C21-H20-O6
MOLECULAR WEIGHT : 368.41
COMPOUND DESCRIPTOR : Mutagen
Natural Product
SYNONYMS/TRADE NAMES :
* C.I. 75300
* C.I. Natural Yellow 3
* Curcuma
* Curcumin
* Diferuloylmethane
* E 100
* Golden seal
* Haidr
* Halad
* Haldar
* Halud
* Hydrastis
* Indian saffron
* Indian turmeric
* Kacha haldi
* Kurkumin
* Merita earth
* NCI-C61325
* Orange Root
* Souchet
* Turmeric Yellow
* Yellow ginger
* Yellow puccoon
* Yellow root
* Yo-kin
* Zlut prirodni 3

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great
Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
Volume(issue)/page/year: 25,447,1973

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical
Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913-
Volume(issue)/page/year: 64,601,1976

** MUTATION DATA **

TYPE OF TEST : Micronucleus test
TEST SYSTEM : Human Embryo
DOSE/DURATION : 73600 ug/L
REFERENCE :
SNSHBT Senshokutai. Chromosome. (Sensyokutai Gakkai, Kaokusai Kirisutokyo
Daigaku, Mitaka, Tokyo-to, Japan) No.1- 1946- Adopted new numbering
in 1976. Volume(issue)/page/year: (20),574,1980

TYPE OF TEST : DNA inhibition
TEST SYSTEM : Human HeLa cell
DOSE/DURATION : 1 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 18,83,1997

TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Human HeLa cell
DOSE/DURATION : 500 nmol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 18,83,1997

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Embryo
DOSE/DURATION : 36800 ug/L
REFERENCE :
SNSHBT Senshokutai. Chromosome. (Sensyokutai Gakkai, Kaokusai Kirisutokyo
Daigaku, Mitaka, Tokyo-to, Japan) No.1- 1946- Adopted new numbering
in 1976. Volume(issue)/page/year: (20),574,1980

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - rat Bone marrow
DOSE/DURATION : 7980 mg/kg/38W (Continuous)
REFERENCE :
CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969-
Volume(issue)/page/year: 62,111,1990

TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - mouse Bone marrow
DOSE/DURATION : 25 mg/kg
REFERENCE :
CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969-
Volume(issue)/page/year: 62,111,1990

TYPE OF TEST : Micronucleus test
TEST SYSTEM : Human Lung
DOSE/DURATION : 73600 ug/L
REFERENCE :
SNSHBT Senshokutai. Chromosome. (Sensyokutai Gakkai, Kaokusai Kirisutokyo
Daigaku, Mitaka, Tokyo-to, Japan) No.1- 1946- Adopted new numbering
in 1976. Volume(issue)/page/year: (20),574,1980

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 20 mg/L
REFERENCE :
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring
St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year:
27,95,1981

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4425
No. of Facilities: 145 (estimated)
No. of Industries: 3
No. of Occupations: 3
No. of Employees: 690 (estimated)

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion

EPA TSCA Section 8(b) CHEMICAL INVENTORY


*** END OF RECORD ***
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Heparin, hydrogen sulfate, sodium salt 37270-89-6
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Heparitin sulfate 9050-30-0
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Guanidine,1-(4,6-dimethyl-2-pyrimidinyl)-3-(p-iodophenyl)- 16018-67-0
9-Heptacosanone 32666-58-3
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Heptadecane 629-78-7
Heptadecane, 9-aza-1,17-diguanidino-, sesquisulphate 26643-62-9
Heptadecanoic acid 506-12-7
Heptadecanol (mixed primary isomers) 52783-44-5
9-Heptadecanone 540-08-9
Guanidine,1-(4,6-dimethyl-2-pyrimidinyl)-3-(p-nitrophenyl)- 4323-53-9
2,8,10-Heptadecatriene-4,6-diyne-1,14-diol, (Z,E,E)- 111128-27-9
8,10,12-Heptadecatriene-4,6-diyne-1,14-diol,(E,E,E)-(-)- 505-75-9
2,8,10-Heptadecatriene-4,6-diyne-1,14-diol,14-acetate, (Z,E,E)- 111128-30-4
Heptadecylamine, N,N-dimethyl-, hydrochloride 2016-44-6
Heptadecylamine, hydrochloride 1838-07-9
2,4-Heptadienal 5910-85-0
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2,6-Heptadienamide,7-(2'-(1,6-dimethyl-2,4-heptadienyl)(2,4'-bithiazol)-4-yl)-3,5-dimethoxy- 4-methyl- 76706-55-3
1,6-Heptadien-4-amine, 4-(2-propenyl)-, ethanedioate(1:1) 56065-61-3
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1,6-Heptadiene, 4-phenyl- 13064-21-6
2,5-Heptadienoic acid,7-(2-(4-(3-chlorophenoxy)-3-hydroxy-1-butenyl)-3,5-dihydroxycyclopentyl)-,(1R-(1-alpha(2E,5Z),2-beta(1E,3R*),3-alpha,5-alpha))- 73275-75-9
2,5-Heptadienoic acid,7-(2-(4-(3-chlorophenoxy)-3-hydroxy-1-butenyl)-3,5-dihydroxycyclopentyl)-, methyl ester,(1R-(1-alpha(2E,5E),2-beta(1E,3R*),3-alpha,5-alpha))- 68399-12-2
2,5-Heptadienoic acid,7-(2-(4-(3-chlorophenoxy)-3-hydroxy-1-butenyl)-3,5-dihydroxycyclopentyl)-, methyl ester,(1R-(1-alpha(2E,5Z),2-beta(1E,3R*),3-alpha,5-alpha))- 62524-99-6
2,5-Heptadienoic acid,7-(2-(4-(4-chlorophenoxy)-3-hydroxy-1-butenyl)-3,5-dihydroxycyclopentyl)-, methyl ester,(1R-(1-alpha(2E,5E),2-beta(1E,3R*),3-alpha,5-alpha))- 62524-99-6
2,5-Heptadienoic acid,7-(2-(4-(4-chlorophenoxy)-3-hydroxy-1-butenyl)-3,5-dihydroxycyclopentyl)-, methyl ester,(1R-(1-alpha(2E,5Z),2-beta(1E,3R*),3-alpha,5alpha))- 62524-99-6
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3,5-Heptadienoic acid,7-(2-(4-(3-chlorophenoxy)-3-hydroxy-1-butenyl)-3,5-dihydroxycyclopentyl)-, methyl ester,(1R-(1-alpha(3E,5Z),2-beta(1E,3R*),3-alpha,5-alpha))- 64812-64-2
Guanidine, 1,1-dimethyl-, sulfate 1186-46-5

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