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MSDS  : 5-Indanol, 6-((2-methylpiperidino)methyl)-, maleate, (+-)-
CAS  : 53305-31-0
SYNONYMS  : * 1H-Inden-5-ol, 2,3-dihydro-6-((2-methyl-1-piperidinyl)methyl)-, (Z)-2-butenedioate, (+-)- * (+-)-6-((2-Methylpiperidino)methyl)-5-indanol maleate * Pipecolinomethylhydroxyindane maleate * DL-6-(N-alpha-Pipecolinomethyl)-5-hydroxy-indane maleate * (+-)-Pmhi maleate
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : NK7534700
CHEMICAL NAME : 5-Indanol, 6-((2-methylpiperidino)methyl)-, maleate,
(+-)-
CAS REGISTRY NUMBER : 53305-31-0
LAST UPDATED : 199506
DATA ITEMS CITED : 18
MOLECULAR FORMULA : C16-H23-N-O.C4-H4-O4
MOLECULAR WEIGHT : 361.48
WISWESSER LINE NOTATION : L56T&J GQ H1- AT6NTJ B1 &QV1U1VQ
COMPOUND DESCRIPTOR : Reproductive Effector
SYNONYMS/TRADE NAMES :
* 1H-Inden-5-ol, 2,3-dihydro-6-((2-methyl-1-piperidinyl)methyl)-,
(Z)-2-butenedioate, (+-)-
* (+-)-6-((2-Methylpiperidino)methyl)-5-indanol maleate
* Pipecolinomethylhydroxyindane maleate
* DL-6-(N-alpha-Pipecolinomethyl)-5-hydroxy-indane maleate
* (+-)-Pmhi maleate

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 115 mg/kg
TOXIC EFFECTS :
Reproductive - Paternal Effects - other effects on male
Endocrine - androgenic
REFERENCE :
ARANDR Archives of Andrology. (Elsevier Science Pub. Co., Inc., 52
Vanderbilt Ave., New York, NY 10017) V.1- 1978- Volume(issue)/page/year:
1,185,1978

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 150 mg/kg
SEX/DURATION : male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Fertility - male fertility index (e.g. # males impregnating
females per # males exposed to fertile nonpregnant females)
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
Volume(issue)/page/year: 37,441,1974

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 4 mg/kg
SEX/DURATION : male 10 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
Volume(issue)/page/year: 38,395,1974

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 63 mg/kg
SEX/DURATION : male 21 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
Volume(issue)/page/year: 38,387,1974

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 525 mg/kg
SEX/DURATION : female 21 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
Volume(issue)/page/year: 38,387,1974

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 28 mg/kg
SEX/DURATION : male 10 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
accessory glands
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
Volume(issue)/page/year: 38,395,1974

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 115 mg/kg
SEX/DURATION : male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
accessory glands
REFERENCE :
ARANDR Archives of Andrology. (Elsevier Science Pub. Co., Inc., 52
Vanderbilt Ave., New York, NY 10017) V.1- 1978- Volume(issue)/page/year:
1,185,1978

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 115 mg/kg
SEX/DURATION : male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - other effects on male
Endocrine - androgenic
REFERENCE :
ARANDR Archives of Andrology. (Elsevier Science Pub. Co., Inc., 52
Vanderbilt Ave., New York, NY 10017) V.1- 1978- Volume(issue)/page/year:
1,185,1978

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 1500 mg/kg
SEX/DURATION : male 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
accessory glands
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
Volume(issue)/page/year: 25,367,1987

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 50 mg/kg
SEX/DURATION : male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
accessory glands
REFERENCE :
ARANDR Archives of Andrology. (Elsevier Science Pub. Co., Inc., 52
Vanderbilt Ave., New York, NY 10017) V.1- 1978- Volume(issue)/page/year:
1,185,1978

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 50 mg/kg
SEX/DURATION : male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - other effects on male
Endocrine - androgenic
REFERENCE :
ARANDR Archives of Andrology. (Elsevier Science Pub. Co., Inc., 52
Vanderbilt Ave., New York, NY 10017) V.1- 1978- Volume(issue)/page/year:
1,185,1978

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 120 mg/kg
SEX/DURATION : male 10 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
Volume(issue)/page/year: 38,395,1974

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Mammal - dog
DOSE : 25 mg/kg
SEX/DURATION : male 10 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
Volume(issue)/page/year: 38,395,1974

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Primate - monkey
DOSE : 20 mg/kg
SEX/DURATION : male 10 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
Volume(issue)/page/year: 38,395,1974

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE : 50 mg/kg
SEX/DURATION : male 10 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
Volume(issue)/page/year: 38,395,1974

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE : 50 mg/kg
SEX/DURATION : male 10 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
Volume(issue)/page/year: 38,395,1974

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - hamster
DOSE : 80 mg/kg
SEX/DURATION : male 10 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
Volume(issue)/page/year: 38,395,1974

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Mammal - species unspecified
DOSE : 910 mg/kg
SEX/DURATION : male 7 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
accessory glands
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
Volume(issue)/page/year: 17,724,1979

*** END OF RECORD ***
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Indigofera spicata, seed extract 96159-95-4
Indium 7440-74-6
Indium antimonide 1312-41-0
Indium arsenide 1303-11-3
Indium chloride 10025-82-8
Indium chloride, tetrahydrate 22519-64-8
Indium citrate 4194-69-8
5-Indanol, 6-((2-methylpiperidino)methyl)-,hydrochloride, DL- 4194-69-8
Indium nitrate 13770-61-1
Indium oxide 1312-43-2
Indium phosphide 22398-80-7
Indium sulfate 13464-82-9
Indium, tris(2,4-pentanedionato)- 14405-45-9
1H-Indol-1-amine,N-methyl-3-phenyl-N-(2-(4-(phenylmethyl)-1-piperazinyl)ethyl)-, hydrochloride 14405-45-9
1H-Indol-3-amine,5-methyl-2-phenyl-N-(4-phenyl-2-thiazolyl)- 126193-52-0
1H-Indol-3-amine, 2-phenyl-N-(4-phenyl-2-thiazolyl)- 126193-50-8
Indole 120-72-9
Indole, nitrosated 120-72-9
5-Indanol, 6-((2-methylpiperidino)methyl)-, maleate,(+-)- 53305-31-0
Indole, pyrolyzate 53305-31-0
1H-Indole-3-acetamide,N-(2-(3,4-bis(phenylmethoxy)phenyl)ethyl)-5-(phenylmethoxy)- 70265-26-8
1H-Indole-3-acetamide,1-(4-chlorobenzoyl)-N-cyclopentyl-5-methoxy-2-methyl- 67370-00-7
Indole-3-acetamide,1-(p-chlorobenzoyl)-5-methoxy-2-methyl- 6264-33-1
1H-Indole-3-acetamide,1-(4-chlorobenzoyl)-5-methoxy-2-methyl-N-(((4-morpholinylmethyl)amino) carbonyl)- 70920-05-7
1H-Indole-1-acetamide, N-cyclohexyl-2-methyl- 163629-07-0
1H-Indole-1-acetamide, N-cyclohexyl-2-phenyl- 163629-08-1
Indole-3-acetamide, N,N-dibutyl- 163629-08-1
1H-Indole-1-acetamide, N,N-diethyl-2-methyl- 163629-06-9
1H-Indole-1-acetamide, N,N-diethyl-2-phenyl- 65746-63-6
1-Indanol, 2-(1-methyl-4-piperidyl)- 20845-57-2
1H-Indole-1-acetamide,2,3-dihydro-3,3-diphenyl-N-hydroxy-5-methoxy-2-oxo- 72935-75-2
1H-Indole-3-acetamide,N-(2-(3,4-dihydroxyphenyl)ethyl)-5-(phenylmethoxy)- 70265-25-7
1H-Indole-3-acetamide,N,N-dimethyl-4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-, (E)-2-butenedioate (1:1) (salt) 145296-55-5
Indole-2-acetamide,N-(5,5-dimethyl-2-oxotetrahydro-3-furyl)- 77694-41-8
1H-Indole-3-acetamide,4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-,monohydrochloride 145296-54-4
1H-Indole-1-acetamide, 2-methyl-N-(2-methylpropyl)- 163629-04-7
1H-Indole-1-acetamide, 2-methyl-N-(phenylmethyl)- 163629-13-8
1H-Indole-3-acetamide,N-(4-(4-(4-methylphenyl)-1-piperazinyl)phenyl)- 81807-90-1

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