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MSDS  : Alanine, 3-((carboxymethyl)thio)-, L-
CAS  : 638-23-3
SYNONYMS  : * Carbocisteine * Carbocysteine * L-Carboxymethylcysteine * (R)-S-(Carboxymethyl)cysteine * S-(Carboxymethyl)-L-cysteine * 3-(Carboxymethylthio)-L-alanine * L-3-((Carboxymethyl)thio)alanine * L-Cysteine, S-(carboxymethyl)- * L.J. 206 * Mucodyne * Rhinathiol * Rinatiol * Thiodril
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : AY4342000
CHEMICAL NAME : Alanine, 3-((carboxymethyl)thio)-, L-
CAS REGISTRY NUMBER : 638-23-3
BEILSTEIN REFERENCE NO. : 1725012
REFERENCE : 4-04-00-03150 (Beilstein Handbook Reference)
LAST UPDATED : 199707
DATA ITEMS CITED : 9
MOLECULAR FORMULA : C5-H9-N-O4-S
MOLECULAR WEIGHT : 179.21
WISWESSER LINE NOTATION : QVYZ1S1VQ -L
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Carbocisteine
* Carbocysteine
* L-Carboxymethylcysteine
* (R)-S-(Carboxymethyl)cysteine
* S-(Carboxymethyl)-L-cysteine
* 3-(Carboxymethylthio)-L-alanine
* L-3-((Carboxymethyl)thio)alanine
* L-Cysteine, S-(carboxymethyl)-
* L.J. 206
* Mucodyne
* Rhinathiol
* Rinatiol
* Thiodril

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >15 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-
Volume(issue)/page/year: 24,1705,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 7800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,190,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10300 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
Japan) V.1- 1950- Volume(issue)/page/year: 32,993,1981

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 8400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,190,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1433 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15
Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881-
Volume(issue)/page/year: 94,1419,1974

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 9 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,190,1982

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 11250 mg/kg/30D-I
TOXIC EFFECTS :
Blood - changes in erythrocyte (RBC) count
Blood - changes in platelet count
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
Japan) V.1- 1950- Volume(issue)/page/year: 32,993,1981

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 625 mg/kg
SEX/DURATION : female 17-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - physical
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 13,1311,1979

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Alanine, 3-(p-boronophenyl)- 90580-64-6
5'-Adenylic acid, monoanhydride with sulfuric acid 485-84-7
Alanine, N-(p-bromobenzenesulfonyl)-3-phenyl-, D- 40279-98-9
Alanine, N-(p-bromobenzenesulfonyl)-3-phenyl-, DL- 37642-61-8
Alanine, N-((5-bromo-3-indolyl)oxalyl)-, DL- 97500-74-8
beta-Alanine, N-(5-bromo-1-naphthyl)-, sodium salt 34592-40-0
Alanine, N-(3-bromo-1-oxopropyl)-3-(p-chlorophenyl)-,DL- 55327-84-9
beta-Alanine,N-butyl-N-(((((2,3-dihydro-2,2-dimethyl-7-benzofuranyl)oxy)carbonyl)methyl amino)thio)-, ethyl ester 82560-59-6
beta-Alanine,N-butyl-N-(((((2,3-dihydro-2,2-dimethyl-7-benzofuranyl)oxy)carbonyl)methyl amino)thio)-, methyl ester 82560-62-1
beta-Alanine, N-butyl-N-nitroso- 62018-92-2
Alanine, N-(3-(3-carbamoylacrylamido)alanyl)-, (E)-L- 36051-75-9
beta-Alanine,N-(3-carbamoyl-5-methoxyacetamido-2,4,6-triiodobenzoyl)- 57469-53-1
5'-Adenylic acid, polymers, complex with 5'-uridylicacid polymers (1:1) 24936-38-7
Alanine, 3-(3-carbamoyl-4-methoxyphenyl)-, DL- 13406-48-9
Alanine, 3-(3-carbamoyl-4-methoxyphenyl)-,monohydrochloride, DL- 16277-17-1
Alanine, N-carbamoyl-N-nitroso-, ethyl ester 67792-93-2
Alanine, N-carbamoyl-N-nitroso-3-phenyl- 67792-90-9
Alanine, N-carbamoyl-N-nitroso-3-phenyl-, ethyl ester 67792-89-6
Alanine, N-carboxy-N-(chloroacetyl)-, N-benzyl ester 67792-89-6
Alanine, 3-((2-carboxyethyl)thio)- 4033-46-9
Alanine, N-(carboxymethyl)-, N-tert-butyl ester,3-ester with 3-beta,14-dihydroxy-5-beta-card-20(22)-enolide, D- 81072-25-5
Alanine, N-(carboxymethyl)-, N-tert-butyl ester,3-ester with 3-beta,14-dihydroxy-5-beta-card-20(22)-enolide, L- 81072-26-6
beta-Alanine, N-carboxymethyl-N-nitro- 10526-60-0
5'-Adenylic acid, potassium salt 35170-28-6
Alanine, 3-((carboxymethyl)thio)- 2387-59-9
Alanine, 3-((carboxymethyl)thio)-, L- 638-23-3
Alanine, N-carboxy-3-phenyl-, N-benzyl ester, L- 1161-13-3
Alanine,N-(chloroacetyl)-3-phenyl-N-(p-tolylsulfonyl)- 102516-65-4
Alanine,N-((1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetyl)-, DL- 76812-17-4
Alanine,N-((1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetyl)-3-(methyl thio)- 87270-38-0
Alanine,N-((1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetyl)-3-phenyl-, DL- 76823-26-2
Alanine, N-(p-chlorobenzoyl)-3-phenyl-, ethyl ester 19064-51-8
beta-Alanine, N-(p-chlorobenzoyl)-N-2,6-xylyl- 30544-73-1
L-Alanine, 3-((2-chloroethenyl)thio)- 115453-71-9
3'-Adenylic acid, sodium salt 54835-81-3
Alanine,3-(p-((2-chloroethyl)(2-fluoroethyl)amino)phenyl)- 1222-64-6
beta-Alanine, N-(2-chloroethyl)-N-methyl-,hydrochloride 89583-19-7
beta-Alanine, N-(2-chloroethyl)-N-methyl-, methylester, hydrochloride 89796-55-4
Alanine, N-(((2-chloroethyl)nitrosoamino)carbonyl)-,DL- 52320-86-2
L-Alanine,N-(((2-chloroethyl)nitrosoamino)carbonyl)-,(17-beta)-3-hydroxyestra-1,3,5(10)- trien-17-yl ester 93398-55-1
L-Alanine,N-(((2-chloroethyl)nitrosoamino)carbonyl)-,(17-beta)-17-hydroxyestra-1,3,5(10)- trien-3-yl ester 89083-85-2
Alanine,N-(((2-chloroethyl)nitrosoamino)carbonyl)-2-methyl- 52320-87-3
Alanine,N-(((2-chloroethyl)nitrosoamino)carbonyl)-3-phenyl-,DL- 52322-29-9
Alanine, N-((2-chloroethyl)nitrosocarbamoyl)- 80687-07-6
beta-Alanine, N-((2-chloroethyl)nitrosocarbamoyl)- 79955-38-7
5'-Adenylic acid, sodium salt 13474-03-8
Alanine, N-((2-chloroethyl)nitrosocarbamoyl)-, benzylester, L- 96408-99-0
Alanine,N-(3-(2-chloroethyl)-3-nitrosoureido)-3-phenyl- 74729-50-3
Alanine, 3-((2-chloroethyl)thio)- 28361-96-8
Alanine,N-((5-chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl)- 54952-08-8

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