*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : OD9910000
CHEMICAL NAME : Laetrile
CAS REGISTRY NUMBER : 1332-94-1
BEILSTEIN REFERENCE NO. : 5608756
LAST UPDATED : 199612
DATA ITEMS CITED : 6
MOLECULAR FORMULA : C14-H15-N-O7
MOLECULAR WEIGHT : 309.30
COMPOUND DESCRIPTOR : Mutagen
Human
SYNONYMS/TRADE NAMES :
* Cyanophenylmethyl-beta-D-glucopyranosiduronic acid
* l-Mandelonitrile-beta-glucuronic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 60 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - hypermotility, diarrhea
Liver - fatty liver degeneration
REFERENCE :
SMJOAV Southern Medical Journal. (Southern Medical Assoc., POB 2446,
Birmingham, AL 35205) V.1- 1908- Volume(issue)/page/year: 79,259,1986
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 198 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Behavioral - hallucinations, distorted perceptions
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year:
239,1532,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 1286 mg/kg/24W
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Sense Organs and Special Senses (Eye) - ptosis
Behavioral - muscle weakness
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year:
238,1361,1977
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Multiple routes
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 4170 mg/kg/8W
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
Skin and Appendages - dermatitis, other (after systemic exposure)
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For
publisher information, see JNCIEQ. Volume(issue)/page/year: 62,169,1978
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 250 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - cyanosis
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year:
242,169,1979
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 9600 pmol/plate
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:
198,625,1977
*** END OF RECORD ***
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| ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| | NAME | CAS |
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Lactic acid, 3,3,3-trifluoro-, methyl ester, dihexylphosphate
| 108682-55-9 |
|
Lactic acid, 3,3,3-trifluoro-, methyl ester,diisobutyl phosphate
| 108682-57-1 |
|
Lactic acid, 3,3,3-trifluoro-, methyl ester,diisopropyl phosphate
| 108682-52-6 |
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Lactic acid, 3,3,3-trifluoro-, methyl ester, dimethylphosphate
| 108682-50-4 |
|
Lactic acid, 3,3,3-trifluoro-, methyl ester, dipentylphosphate
| 108682-54-8 |
|
Lactic acid, 3,3,3-trifluoro-, methyl ester, dipropylphosphate
| 108698-12-0 |
|
Lactic acid, compd. with tylosin (11)
| 11034-63-2 |
|
Lactic acid, zinc salt (21), DL-
| 11034-63-2 |
|
Juncus monticola Steud., extractSUBSTANCE DEFINITION :Plant belonging to the family JuncaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 11034-63-2 |
|
Lactic dehydrogenase C(sub 4)
| 11034-63-2 |
|
Lactic dehydrogenase X
| 11034-63-2 |
|
Lactobionic acid, compd. with erythromycin (11)
| 3847-29-8 |
|
LactolinSUBSTANCE DEFINITION :Isolated from Lactobacillus plantarium and Oenothera caespitosaREFERENCE :85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., BocaRaton, FL, CRC Press, 1980- Volume(issue)/page/year: 7,138,1980
| 3847-29-8 |
|
Lactonitrile
| 78-97-7 |
|
Lactonitrile, 3-chloro-
| 33965-80-9 |
|
Lactonitrile, diethylamino-
| 33965-80-9 |
|
Lactonitrile, 3-(diethylamino)-, methyl iodide
| 93115-66-3 |
|
Lactonitrile, 2-methyl-
| 75-86-5 |
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Lactonitrile, 2-methyl-3,3,3-trifluoro-, acetate
| 4588-51-6 |
|
Juniparus communis Linn., seed extractSUBSTANCE DEFINITION :Plant belonging to the family PinaceaeREFERENCE :INDRBA Indian Drugs. (Indian Drugs Manufacturers' Assoc., 102B, PoonamChambers, Dr. A. B. Rd., Worli, Bombay 400 018, India) V.1- 1963-Volume(issue)/page/year: 30,19,1993
| 4588-51-6 |
|
Lactonitrile, 3,3,3-trichloro-
| 513-96-2 |
|
Lactonitrile, 2-(trifluoromethyl)-BEILSTEIN REFERENCE NO. : 1758723REFERENCE : 4-03-00-00796 (Beilstein Handbook Reference)
| 513-96-2 |
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Lactoquinomycin B
| 101342-94-3 |
|
Lactose
| 63-42-3 |
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Lactostrepcin 5
| 96697-31-3 |
|
Lactuca brunoniana (wall.) Clarke, extractSUBSTANCE DEFINITION :Plant belonging to the family CompositaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 9,91,1971
| 96697-31-3 |
|
Lactuca sativa L. var. capitata, extract
| 84776-66-9 |
|
Lactuca sativa L. var. longifolia, seed oil
| 84776-66-9 |
|
Lactuca Sativa L., var. Romana Hort., seed extract
| 84776-66-9 |
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Lactuca scariola L. var. sativa Cl., extractSUBSTANCE DEFINITION :Plant belonging to the family AsteraceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 28,619,1990
| 84776-66-9 |
|
Juniper berry oil
| 8002-68-4 |
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Lactuca serriola Linn., extractSUBSTANCE DEFINITION :Plant belonging to the family CompositaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 8002-68-4 |
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Ladino clover
| 8002-68-4 |
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Ladner's mixtureSUBSTANCE DEFINITION :A mixture of epsom salts, copperas, sulfur, hydrated lime, spirits ofturpentine and nicotineREFERENCE :JEENAI Journal of Economic Entomology. (Entomological Soc. of America, 4603Calvert Rd., College Park, MD 20740) V.1- 1908- Volume(issue)/page/year:48,139,1955
| 8002-68-4 |
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Laennec
| 8002-68-4 |
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Laetia thamnia L., leaf and stem extractSUBSTANCE DEFINITION :Plant belonging to the family FlacourtiaceaeREFERENCE :JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of GreatBritain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-Volume(issue)/page/year: 16,115,1964
| 8002-68-4 |
|
Laetrile
| 1332-94-1 |
|
Lagenaria breviflora Robert, fruit extractSUBSTANCE DEFINITION :Plant belonging to the family CucurbitaceaeREFERENCE :JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. IrelandLtd., POB 85, Limerick, Ireland) V.1- 1979-
| 1332-94-1 |
|
Lagenaria siceraria (molina) Standl., extractexcluding rootsSUBSTANCE DEFINITION :Plant belonging to the family CucurbitaceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 22,312,1984
| 1332-94-1 |
|
Lagenaria sphaerica (Sond.) Naud., extractSUBSTANCE DEFINITION :African plant belonging to the family CucurbitaceesREFERENCE :JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. IrelandLtd., POB 85, Limerick, Ireland) V.1- 1979-
| 1332-94-1 |
|
Lagenaria sphaerica (sond.) Naud., leaf extractSUBSTANCE DEFINITION :Plant belonging to the family CucurbitaceaeREFERENCE :JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. IrelandLtd., POB 85, Limerick, Ireland) V.1- 1979-
| 1332-94-1 |
|
Juniper tar
| 8013-10-3 |
|
Lagerstroemia hypoleuca Kurz, extractSUBSTANCE DEFINITION :Plant belonging to the family LythraceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 28,619,1990
| 8013-10-3 |
|
Lagerstroemia indica L., leaf and stem extractSUBSTANCE DEFINITION :Plant belonging to the family LythraceaeREFERENCE :JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of GreatBritain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-Volume(issue)/page/year: 16,115,1964
| 8013-10-3 |
|
Lagerstroemia lanceolata Wall., extract excludingrootsSUBSTANCE DEFINITION :Plant belonging to the family LythraceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 8013-10-3 |
|
Lagerstroemia parviflora Roxb., extract excludingrootsSUBSTANCE DEFINITION :Plant belonging to the family LythraceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 8013-10-3 |
|
Lagerstroemia speciosa Linn., extractSUBSTANCE DEFINITION :Plant belonging to the family LythraceaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
| 8013-10-3 |
|
Lagerstroemia speciosa Pers., extractSUBSTANCE DEFINITION :Plant belonging to the family LythraceaeREFERENCE :CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA,1255 Howard St., San Francisco, CA 94103) V.6- 1958-Volume(issue)/page/year: 13,882,1965
| 8013-10-3 |
|
Laminaran, hydrogen sulfate
| 9008-23-5 |
|
Laminaria japonica Aresch., extract
| 9008-23-5 |
|
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