RTECS NUMBER : OK6684000
CHEMICAL NAME : Luteinizing hormone-releasing hormone, (D-phe(sup
2)-D-trp(sup 3)-D-phe(sup 6))-
LAST UPDATED : 198910
DATA ITEMS CITED : 3
COMPOUND DESCRIPTOR : Reproductive Effector
Human
Hormone
SYNONYMS/TRADE NAMES :
* Luteinizing hormone-releasing hormone, (D-phe-2,D-trp-3,D-phe-6)-
* (D-Phe-2,D-trp-3,D-phe-6)-LHRH
* (D-Phe(sup 2)-D-trp(sup 3)-D-phe(sup 6))-LHRH
* (D-Phe-2,D-trp-3,D-phe-6)-luteinizing hormone-releasing hormone
* (D-Phe(sup 2)-D-trp(sup 3)-D-phe(sup 6))-luteinizing hormone-releasing
hormone
*** HEALTH HAZARD DATA ***
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Human - man
DOSE : 1286 ug/kg
SEX/DURATION : male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - other effects on male
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
Volume(issue)/page/year: 2,997,1977
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Human - woman
DOSE : 1800 ug/kg
SEX/DURATION : female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
Reproductive - Maternal Effects - other effects
Reproductive - Fertility - other measures of fertility
REFERENCE :
INJFA3 International Journal of Fertility. (Allen Press, 1041 New
Hampshire, St., Lawrence, KS 66044) V.1- 1955- Volume(issue)/page/year:
25,190,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 5 mg/kg
SEX/DURATION : female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
20037) V.6- 1963- Volume(issue)/page/year: 21,276,1978
*** END OF RECORD ***
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