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MSDS  : Luteinizing hormone-releasing factor (pig), 6-D-alanine-9-N-ethyl-L-prolinamide)-10- deglicinamide-
CAS  : 52435-06-0
SYNONYMS  : * (D-Ala(sup 6)-des-gly-NH2(sup 10))LHRH ethylamide * (D-Ala(sup 6)-des-gly-NH2(sup 10))-luteinizing hormone-releasing hormone ethylamide * 6-D-Alanine-9-(N-ethyl-L-prolinamide)-10-deglycinamide-luteinizing hormone-releasing hormone * AY-25,205 * TAP 127 * WY 18481
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : OK6420000
CHEMICAL NAME : Luteinizing hormone-releasing factor (pig),
6-D-alanine-9-N-ethyl-L-prolinamide)-10-
deglicinamide-
CAS REGISTRY NUMBER : 52435-06-0
OTHER CAS REGISTRY NOS. : 56136-33-5
BEILSTEIN REFERENCE NO. : 0906592
LAST UPDATED : 199706
DATA ITEMS CITED : 20
MOLECULAR FORMULA : C56-H78-N16-O12
MOLECULAR WEIGHT : 1167.50
COMPOUND DESCRIPTOR : Reproductive Effector
Human
Hormone
SYNONYMS/TRADE NAMES :
* (D-Ala(sup 6)-des-gly-NH2(sup 10))LHRH ethylamide
* (D-Ala(sup 6)-des-gly-NH2(sup 10))-luteinizing hormone-releasing hormone
ethylamide
* 6-D-Alanine-9-(N-ethyl-L-prolinamide)-10-deglycinamide-luteinizing
hormone-releasing hormone
* AY-25,205
* TAP 127
* WY 18481

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
REFERENCE :
AEFTAA Acta Europaea Fertilitatis. (COFESE Eds., Piazzale Ungheria 73,
90141 Palermo, Italy) V.1- 1969- Volume(issue)/page/year: 11,113,1980

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Human - woman
DOSE : 12 ug/kg
SEX/DURATION : female 3 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - oogenesis
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
SCYYDZ Shengzhi Yu Biyun. Reproduction and Contraception. (China
International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1980-
Volume(issue)/page/year: 11(4),29,1991

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Human - woman
DOSE : 30 ug/kg
SEX/DURATION : female 3 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
REFERENCE :
SCYYDZ Shengzhi Yu Biyun. Reproduction and Contraception. (China
International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1980-
Volume(issue)/page/year: 11(4),29,1991

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Human - woman
DOSE : 20 ug/kg
SEX/DURATION : female 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - oogenesis
Reproductive - Maternal Effects - menstrual cycle changes or disorders
Reproductive - Maternal Effects - other effects
REFERENCE :
SCYYDZ Shengzhi Yu Biyun. Reproduction and Contraception. (China
International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1980-
Volume(issue)/page/year: 11(4),29,1991

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 3500 ug/kg
SEX/DURATION : female 1-7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
IJGOAL International Journal of Gynaecology & Obstetrics. (Elsevier
Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.7- 1969-
Volume(issue)/page/year: 16,359,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 30 mg/kg
SEX/DURATION : female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
IJGOAL International Journal of Gynaecology & Obstetrics. (Elsevier
Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.7- 1969-
Volume(issue)/page/year: 16,359,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 300 ug/kg
SEX/DURATION : female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
IJGOAL International Journal of Gynaecology & Obstetrics. (Elsevier
Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.7- 1969-
Volume(issue)/page/year: 16,359,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 2500 ng/kg
SEX/DURATION : male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston
St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year:
103,641,1978

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 8400 ug/kg
SEX/DURATION : male 21 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
accessory glands
REFERENCE :
JOAND3 Journal of Andrology. (Lippincott/Harper, Journal Fulfillment Dept.,
2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1980-
Volume(issue)/page/year: 2,152,1981

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 360 ng/kg
SEX/DURATION : male 9 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - other effects on male
REFERENCE :
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W.
Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year:
22,1094,1980

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 35 ug/kg
SEX/DURATION : female 1-7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
Reproductive - Fertility - other measures of fertility
REFERENCE :
IJGOAL International Journal of Gynaecology & Obstetrics. (Elsevier
Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.7- 1969-
Volume(issue)/page/year: 16,359,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE : 50 ng/kg
SEX/DURATION : female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - mating performance (e.g. # sperm positive females
per # females mated; # copulations per # estrus cycles)
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
Volume(issue)/page/year: 44,87,1975

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE : 100 ng/kg
SEX/DURATION : female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S,
Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 27,1078,1976

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE : 500 ug/kg
SEX/DURATION : female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
IJGOAL International Journal of Gynaecology & Obstetrics. (Elsevier
Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.7- 1969-
Volume(issue)/page/year: 16,359,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - rat
DOSE : 32 ug/kg
SEX/DURATION : male 8 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - other effects on male
REFERENCE :
JSTBBK Journal of Steroid Biochemistry. (Pergamon Press Ltd., Headington
Hill Hall, Oxford OX3 0BW, UK) V.1- 1969- Volume(issue)/page/year:
13,191,1980

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - rat
DOSE : 2100 ug/kg
SEX/DURATION : female 84 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston
St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year:
104,1369,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - rat
DOSE : 2 ug/kg
SEX/DURATION : male 4 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston
St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year:
104,1369,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - rat
DOSE : 8 ug/kg
SEX/DURATION : male 16 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
accessory glands
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston
St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year:
104,1369,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE : 7 ug/kg
SEX/DURATION : female 1-7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
IJGOAL International Journal of Gynaecology & Obstetrics. (Elsevier
Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.7- 1969-
Volume(issue)/page/year: 16,359,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE : 6 ug/kg
SEX/DURATION : female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
IJGOAL International Journal of Gynaecology & Obstetrics. (Elsevier
Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.7- 1969-
Volume(issue)/page/year: 16,359,1979

*** END OF RECORD ***
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NAMECAS
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Levatera kashmeriana Comp., extractSUBSTANCE DEFINITION :Plant belonging to the family LeguminosaeREFERENCE :IJEBA6 Indian Journal of Experimental Biology. (Publications & InformationDirectorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-Volume(issue)/page/year: 16,228,1978 64789-67-9
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Luteinizing hormone-releasing factor(pig),2-D-phenylalanine-3-L-valine-6-D-tryptophan- 64891-34-5
Luteinizing hormone-releasing factor(pig),6-(gamma-phenyl-D-alpha-aminobenzenebutanoicacid)-9-(N-ethyl-L-prolinamide)-10-deglycinamide-,monoacetate (salt) 82318-10-3
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Luteinizing hormone-releasing factor(pig),6-(4-(trifluoromethyl)-D-phenylalanine)-, monoacetate(salt) 82317-98-4
Luteinizing hormone-releasing factor(pig),6-(2,4,6-trimethyl-D-phenylalanine)-, monoacetate(salt) 82317-99-5
Luteinizing hormone-releasing factor (pig),6-D-tryptophan-7-(N-methyl-L-leucine)-9-(N-ethyl-L-prolinamide)-10-deglycinamide-, monoacetate (salt) 83784-18-3
Luteinizing hormone-releasing hormone 9034-40-6
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Levomycin 1403-88-9
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Luteinizing hormone-releasing hormone,(N-AC-D-p-Cl-phe(sup 1,2)-D-trp(sup 3)-D-phe(sup 6)-D-ser(sup 10))- 1403-88-9
Luteinizing hormone-releasing hormone,(AC-dehydro-pro(sup 1)-p-Cl-D-phe(sup 2)- D-trp(sup3,6))-N(sup alpha)-Me-leu(sup 7)- 1403-88-9
Luteinizing hormone-releasing hormone,(N-AC-D-p-F-phe(sup 1)-D-p-Cl-phe(sup 2)- D-trp(sup3,6)-D-ala(sup 10))- 1403-88-9
Luteinizing hormone-releasing hormone, (AC-hyp(sup1)-D-phe(sup 2)-D-trp(sup 3)- D-trp(sup 6))- 1403-88-9
Luteinizing hormone-releasing hormone,(N-AC-DL-5-Me-trp(sup 1)-D-p-Cl-phe(sup 2)- D-trp(sup3)-D-phe(sup 6)-D-ala(sup 10))- 1403-88-9
Luteinizing hormone-releasing hormone,(AC-D-nal(2)(sup 1)-p-F-D-phe(sup 2)-D-trp(sup 3)-D-arg(sup 6))- 86855-16-5
Luteinizing hormone-releasing hormone,(N-Ac-D-phe(sup 1)-D-p-Cl-phe(sup 2)-D-trp(sup 3,6)-D-ala(sup 10))- 86855-16-5
Luteinizing hormone-releasing hormone, (AC-D-phe(sup1)-D-phe(sup 2)-D-trp(sup 3,6))- 86855-16-5
Luteinizing hormone-releasing factor (pig),1-(1-acetyl-L-proline)-(4-chloro-D-phenylalanine)-3-(3-(2-naphthalenyl)-D-alanine)-6-(3-(2-naphthalenyl)-D-alanine)- 82778-57-2
Levopimaric acid, compd. with maleic anhydride 82778-57-2
Luteinizing hormone-releasing hormone, (AC-delta(sup3)-pro(sup 1)-p-Cl-D-phe(sup 2)- D-trp(sup 3,6))- 80152-22-3
Luteinizing hormone-releasing hormone, (AC-delta(sup3)-pro(sup 1)-p-Cl-D-phe(sup 2)- D-trp(sup 3,6)-N(supalpha)-Meleu(sup 7))- 80152-22-3
Luteinizing hormone-releasing hormone, (AC-delta(sup3)-pro(sup 1)-p-F-D-phe(sup 2)- D-trp(sup 3,6))- 80152-22-3
Luteinizing hormone-releasing hormone, (AC-pro(sup1)-D-phe(sup 2)-D-trp(sup 3)- D-trp(sup 6))- 80152-22-3
Luteinizing hormone-releasing hormone, (AC-D-thi(sup1)-D-phe(sup 2)-D-trp(sup 3,6))- 80152-22-3
Luteinizing hormone-releasing hormone,(N-AC-D-trp(sup 1,3)-D-p-Cl-phe(sup 2)-D-arg(sup 6)-D-ala(sup 10))- 80152-22-3
Luteinizing hormone-releasing hormone,(N-AC-D-trp(sup 1,3)-D-p-Cl-phe(sup 2)-D-phe(sup 6)-D-ala(sup 10))- 80152-22-3
Luteinizing hormone-releasing hormone,(N-Ac-DL-trp(sup 1)-D-p-Cl-phe(sup 2)-D-trp(sup 3)-D-phe(sup 6)-D-ala(sup 10))- 80152-22-3
Luteinizing hormone-releasing hormone, (AC-D-trp(sup1)-D-phe(sup 2)-D-trp(sup 3,6))- 80152-22-3
Luteinizing hormone-releasing hormone, (D-ala(sup6))- 51230-19-4
Levorin 11014-70-3
Luteinizing hormone-releasing hormone, (D-ala(sup6)-des-gly(sup 10))-, ethylamide 11014-70-3
Luteinizing hormone-releasing factor (pig),6-D-alanine-9-N-ethyl-L-prolinamide)-10-deglicinamide- 52435-06-0
Luteinizing hormone-releasing hormone, D-ala(sup6)-des-gly(sup 10)-pro(sup 9)-, ethylamide 52435-06-0
Luteinizing hormone-releasing hormone, D-ala(sup6)-(N)Me-leu(sup 7)-des-gly(sup 10)- pro(sup 9)-,ethylamide 67910-56-9
Luteinizing hormone-releasing hormone, (D-ala(sup6)-pro-nhet(sup 9))- 67910-56-9
Luteinizing hormone-releasing hormone, (D-bia(sup6))- 67910-56-9
Luteinizing hormone-releasing hormone, (D-bia(sup6),pro(sup 9)-nhet)- 67910-56-9
Luteinizing hormone-releasing hormone, (D-boa(sup6))- 67910-56-9
Luteinizing hormone-releasing hormone,boc-(ser(bzl)(sup 1)-des-his(sup 2)-D-trp(sup 6))-,acetate 67910-56-9
Luteinizing hormone-releasing hormone,boc-(ser(bzl)(sup 1)-des-his(sup 2)-D-trp(sup 6))-,hydrochloride 67910-56-9
Levorin A0 77215-53-3
Luteinizing hormone-releasing hormone conjugated tobovine serum albumin 77215-53-3
Luteinizing hormone-releasing hormone, (D-bta(sup6))- 77215-53-3
Luteinizing hormone-releasing hormone, (D-dcb(sup6))- 77215-53-3

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