RTECS NUMBER : OO1100000
CHEMICAL NAME : Malonic acid, (ethoxymethylene)-, diethyl ester
CAS REGISTRY NUMBER : 87-13-8
OTHER CAS REGISTRY NOS. : 69731-53-9
BEILSTEIN REFERENCE NO. : 0880058
REFERENCE : 4-03-00-01192 (Beilstein Handbook Reference)
LAST UPDATED : 199709
DATA ITEMS CITED : 5
MOLECULAR FORMULA : C10-H16-O5
MOLECULAR WEIGHT : 216.26
WISWESSER LINE NOTATION : 2OVYVO2&U1O2
COMPOUND DESCRIPTOR : Drug
Primary Irritant
SYNONYMS/TRADE NAMES :
* Diethyl EMME
* Diethyl (ethoxymethylene)malonate
* Ethoxymethylenemalonic acid, ethyl ester
* Propanedioic acid, (ethoxymethylene)-, diethyl ester
* TL 1483
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/24H
REACTION SEVERITY : Moderate
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-
1990- Volume(issue)/page/year: 1,37,1990
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 925 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Behavioral - somnolence (general depressed activity)
Gastrointestinal - other changes
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-
1990- Volume(issue)/page/year: 1,37,1990
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2227 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
Volume(issue)/page/year: 60,1810,1971
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 44 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NDRC** National Defense Research Committee, Office of Scientific Research
and Development, Progress Report. Volume(issue)/page/year: 30101,11,1945
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***
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