RTECS NUMBER : OS9275000
CHEMICAL NAME : p-Menthane, 1,8-epoxy-
CAS REGISTRY NUMBER : 470-82-6
LAST UPDATED : 199710
DATA ITEMS CITED : 12
MOLECULAR FORMULA : C10-H18-O
MOLECULAR WEIGHT : 154.28
WISWESSER LINE NOTATION : T66 A B AOTJ B1 B1 F1
COMPOUND DESCRIPTOR : Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Cajeputol
* 1,8-Cineol
* Cineole
* 1,8-Cineole
* 1,8-Epoxy-p-menthane
* Eucalyptol
* Eucalyptole
* Eukalyptol
* NCI-C56575
* 2-Oxabicyclo(2.2.2)octane, 1,3,3-trimethyl-
* 1,8-Oxido-p-menthane
* Terpan
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2480 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - coma
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1070 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory
change
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
SIZSAR Sapporo Igaku Zasshi. Sapporo Medical Journal. (Sapporo Igaku
Daigaku, Nishi-17-chome, Minami-1-jo, Chuo-ku, Sapporo 060, Japan) V.3-
1952- Volume(issue)/page/year: 3,73,1952
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JSICAZ Journal of Scientific and Industrial Research, Section C: Biological
Sciences. (New Delhi, India) V.14-21, 1955-62. For publisher information,
see IJEBA6. Volume(issue)/page/year: 21,342,1962
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 1500 mg/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
TFAKA4 Trudy Instituta Fiziologii, Akademiya Nauk Kazakhshoi SSR.
Transactions of the Institute of Physiology, Academy of Sciences of the
Kazakh. SSR. (Izdatel'stvo Nauka Kazakhskoi SSR, Alma- Ata, USSR) V.1-
1955- Volume(issue)/page/year: 1,134,1955
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 2250 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
TFAKA4 Trudy Instituta Fiziologii, Akademiya Nauk Kazakhshoi SSR.
Transactions of the Institute of Physiology, Academy of Sciences of the
Kazakh. SSR. (Izdatel'stvo Nauka Kazakhskoi SSR, Alma- Ata, USSR) V.1-
1955- Volume(issue)/page/year: 1,134,1955
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 2 gm/kg
SEX/DURATION : female 19-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year:
22,543,1973
** MUTATION DATA **
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 200 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
10(Suppl 10),1,1987
*** REVIEWS ***
TOXICOLOGY REVIEW
DPIRDU Dangerous Properties of Industrial Materials Report. (Van Nostrand
Reinhold, 115 Fifth Ave., New York, NY 10003) V.1- 1981-
Volume(issue)/page/year: 2(4),10,1982
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 19540
No. of Facilities: 1103 (estimated)
No. of Industries: 11
No. of Occupations: 23
No. of Employees: 5213 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 19540
No. of Facilities: 4397 (estimated)
No. of Industries: 48
No. of Occupations: 57
No. of Employees: 83399 (estimated)
No. of Female Employees: 20158 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***
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