Search   
MSDS  
:
 Morphinan-3-ol, 17-methyl-, tartrate (11) (salt),
(-)-
CAS  
:
 125-72-4
SYNONYMS  
:
 * levo-Dromoran tartrate
* L-3-Hydroxy-N-methylmorphinan bitartrate
* L-3-Hydroxy-N-methylmorphinan tartrate
* Lemoran
* Levorphan tartrate
* Levorphanol tartrate
* Ro 1-5431/7

                     *** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QD1925000
CHEMICAL NAME           : Morphinan-3-ol, 17-methyl-, tartrate (1:1) (salt),
                          (-)-
CAS REGISTRY NUMBER     : 125-72-4
LAST UPDATED            : 199504
DATA ITEMS CITED        : 14
MOLECULAR FORMULA       : C17-H23-N-O.C4-H6-O6
MOLECULAR WEIGHT        : 407.51
WISWESSER LINE NOTATION : T6 G666/FQ 2AF Q FX ONT&TTJ IQ O -L &622 QVYQYQVQ
                          &621
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * levo-Dromoran tartrate
   * L-3-Hydroxy-N-methylmorphinan bitartrate
   * L-3-Hydroxy-N-methylmorphinan tartrate
   * Lemoran
   * Levorphan tartrate
   * Levorphanol tartrate
   * Ro 1-5431/7
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 46 mg/kg
TOXIC EFFECTS :
   Behavioral - analgesia
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 149,571,1964
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - rigidity (including catalepsy)
   Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 109,189,1953
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 48 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 14,217,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 110 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - rigidity (including catalepsy)
   Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 109,189,1953
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 27 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 109,171,1957
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 285 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 109,189,1953
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 92 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JJPAAZ Japanese Journal of Pharmacology.  (Japanese Pharmacological Soc.,
   c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto
   606, Japan)  V.1-    1951-  Volume(issue)/page/year: 11,101,1962
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 187 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 109,189,1953
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 32 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 105,221,1956
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 14723 ug/kg
TOXIC EFFECTS :
   Behavioral - analgesia
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 145,11,1964
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 109,171,1957
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 25 mg/kg
SEX/DURATION            : female 9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   DGDFA5 Development, Growth & Differentiation.  (Japan Pub. Trading Co.
   (USA), 1255 Howard St., San Francisco, CA 94103)  V.11-    1969-
   Volume(issue)/page/year: 22,61,1980
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 2500 ug/kg
REFERENCE :
   RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
   Pub. Ltd., P.O. Box 966, Westbury, NY 11590)  V.1-    1970-
   Volume(issue)/page/year: 3,105,1972

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X6071
       No. of Facilities: 23 (estimated)
       No. of Industries: 1
       No. of Occupations: 3
       No. of Employees: 4165 (estimated)
       No. of Female Employees: 3802 (estimated)

 
                            *** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Morphinan-3-ol, 17-(3-ethyl-2-pentenyl)-,hydrobromide, (-)- 63732-79-6
Morphinan-3-ol, 17-(3-ethylpentyl)-, tartrate, (-)- 63732-81-0
Morphinan-3-ol, 17-(3-furanylmethyl)-,methanesulfonate (salt) 61799-82-4
Morphinan-3-ol, 17-(2-(2-furyl)ethyl)-,hydrochloride, (-)- 27767-85-7
Methanone,(6,7-dimethoxy-1-isoquinolinyl)(3,4-dimethoxyphenyl)-, O-(3,4,5-trimethoxy benzoyl)oxime,monohydrochloride 54022-74-1
Morphinan-3-ol, 17-(2-(2-furyl)ethyl)-,hydrochloride, (+)- 63783-57-3
Morphinan-3-ol, 17-(2-(2-furyl)ethyl)-, nicotinate(ester), tartrate, (-)- 63732-83-2
Morphinan-3-ol, 17-hexyl-, hydrochloride, (-)- 63732-84-3
Morphinan-3-ol, hydrobromide, (-)- 63732-85-4
Morphinan-3-ol, 17-(alpha-hydroxybenzyl)methyl-,hydrochloride, (-)- 63732-86-5
Morphinan-3-ol, 17-(2-(2-hydroxyethoxy)ethyl)-,hydrochloride, (-)- 63732-87-6
Morphinan-3-ol,17-(alpha-hydroxy-p-methoxy)phenethyl-,hydrochloride, (-)- 63732-88-7
Morphinan-3-ol, 17-(p-hydroxyphenethyl)-,hydrochloride, (-)- 63732-89-8
Morphinan-3-ol, 17-(3-hydroxypropyl)-, hydrochloride,(-)- 63765-65-1
Morphinan-3-ol, 17-isobutyl-, hydrobromide, (-)- 63743-76-0
Methanone,(2,4-dimethoxyphenyl)(4-(2-propenyloxy)phenyl)- 75226-95-8
Morphinan-3-ol, 17-isopentyl-, hydrochloride, (-)- 63732-90-1
Morphinan-4-ol, 3-methoxy-17-methyl- 3327-79-5
Morphinan-3-ol, 17-(3-methoxymethyl-2-butenyl)-,hydrochloride, (-)- 63732-91-2
Morphinan-3-ol, 17-(4-methoxy-2-methyl)phenethyl-,hydrochloride, (-)- 63732-92-3
Morphinan-14-ol, 3-methoxy-17-methyl-4-phenoxy- 1612-47-1
Morphinan-3-ol, 17-(4-methoxy-3-nitro)phenacyl-,hydrochloride, (-)- 63732-93-4
Morphinan-3-ol, 17-(p-methoxyphenacyl)-,hydrochloride, (-)- 63732-94-5
Morphinan-3-ol, 17-(m-methoxyphenethyl)-,hydrochloride, (-)- 63732-95-6
Morphinan-3-ol, 17-(p-methoxyphenethyl)-,hydrochloride, (-)- 63765-66-2
Morphinan-3-ol, 17-(p-methoxyphenethyl)-, tartrate,(-)- 63732-97-8
Methanone,(4-((dimethylamino)methyl)-5-hydroxy-2-methyl-3-benzofuranyl)(5-methoxy- 2-benzofuranyl)-, hydrochloride 132993-99-8
Morphinan-3-ol, 17-methyl-, (-)- 77-07-6
9-alpha,13-alpha,14-alpha-Morphinan-3-ol, 17-methyl- 125-73-5
Morphinan-3-ol, 17-methyl-, acetate (ester),tartrate, (-)- 63867-86-7
Morphinan-3-ol, 17-(2-methylallyl)-, hydrobromide,(-)- 63867-87-8
Morphinan-3-ol, 17-(3-methyl-2-butenyl)-, (-)- 24921-64-0
Morphinan-3-ol, 17-(3-methyl-2-butenyl)-, nicotinate(ester), tartrate, (-)- 63867-89-0
Morphinan-3-ol, 17-(2-methylbutyl)-, tartrate, (-)- 63867-91-4
Morphinan-3-ol, 17-methyl-, carbonate (21) (ester),hydrochloride, trichloromethane, hydrate (6:1:9),(9-alpha,13-alpha,14-alpha)- 38848-18-9
Morphinan-3-ol, 17-methylcarbonylmethyl-, (-)- 63867-92-5
Morphinan-3-ol, 17-(3,4-methylenedioxy)phenacyl-,hydrobromide, (-)- 63867-93-6
Methanone,(3-(1,1-dimethylethyl)-4-hydroxy-5-((2-hydroxyethyl)methylamino)methyl)phe nyl)-2- thienyl- 124978-79-6
Morphinan-3-ol, 17-(3,4-methylenedioxy)phenethyl-,hydrochloride, (-)- 63867-94-7
Morphinan-3-ol, 17-(3,4-methylenedioxy)phenethyl-,hydrochloride, (+)- 63903-46-8
Morphinan-2-ol, 17-methyl-, hydrobromide 102043-43-6
Morphinan-3-ol, 17-methyl-, hydrobromide, (+-)- 5985-35-3
Morphinan-3-ol, 17-methyl-, nicotinate (ester),tartrate, (-)- 63904-94-9
Morphinan-3-ol, 17-(3-methyl-2-pentenyl)-, tartrate,(-)- 63867-96-9
Morphinan-3-ol, 17-(3-methylpent-2-en-4-ynyl)-,tartrate, (-)- 63867-98-1
Morphinan-3-ol, 17-(3-methylpentyl)-, tartrate, (-)- 63868-00-8
Morphinan-3-ol, N-methyl-, D-tartrate, dihydrate(1:1), (-)- 5985-38-6
Morphinan-3-ol, 17-methyl-, tartrate, hydrate, (+)- 5985-38-6
Methanone,(5,7-dimethyl-4-hydroxy-2-(3-(4-phenyl-1-piperazinyl)propyl)-2H- pyrido(3,5-e)-1,2-thiazin-3-yl)phenyl-,S,S-dioxide 164357-32-8
Morphinan-3-ol, 17-methyl-, tartrate (11) (salt),(-)- 125-72-4

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