Search   
MSDS  : 2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro -3,10,12,12a- tetrahydroxy-1,11-dioxo-
CAS  : 10118-90-8
SYNONYMS  : * CL 59806 * 7-Dimethylamino-6-demethyl-6-deoxytetracycline * Minocyclin * Minocycline
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : QI7630000
CHEMICAL NAME : 2-Naphthacenecarboxamide,
4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro
-3,10,12,12a- tetrahydroxy-1,11-dioxo-
CAS REGISTRY NUMBER : 10118-90-8
BEILSTEIN REFERENCE NO. : 3077644
LAST UPDATED : 199712
DATA ITEMS CITED : 12
MOLECULAR FORMULA : C23-H27-N3-O7
MOLECULAR WEIGHT : 457.53
WISWESSER LINE NOTATION : L E6 C666 BV FV CU GUTTT&J DQ EQ GMVH HQ IN1&1 ON1&1
RQ
COMPOUND DESCRIPTOR : Drug
Mutagen
Human
Natural Product
SYNONYMS/TRADE NAMES :
* CL 59806
* 7-Dimethylamino-6-demethyl-6-deoxytetracycline
* Minocyclin
* Minocycline

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 28 mg/kg/2W-I
TOXIC EFFECTS :
Brain and Coverings - changes in circulation (hemorrhage, thrombosis, etc.)
Sense Organs and Special Senses (Eye) - visual field changes
Behavioral - headache
REFERENCE :
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200
Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year:
127,168,1997

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 343 mg/kg/17W-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), diffuse
Liver - liver function tests impaired
Blood - eosinophilia
REFERENCE :
AJGAAR American Journal of Gastroenterology. (American College of
Gastroenterology, Inc., 428 E. Preston St., Baltimore, MD 21202) V.21-
1954- Volume(issue)/page/year: 91,1641,1996

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 112 mg/kg/4W-I
TOXIC EFFECTS :
Liver - liver function tests impaired
Skin and Appendages - dermatitis, other (after systemic exposure)
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
AJGAAR American Journal of Gastroenterology. (American College of
Gastroenterology, Inc., 428 E. Preston St., Baltimore, MD 21202) V.21-
1954- Volume(issue)/page/year: 91,1641,1996

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - interstitial nephritis
Kidney, Ureter, Bladder - proteinuria
Kidney, Ureter, Bladder - hematuria
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year:
1,524,1979

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 1204 mg/kg/86W-I
TOXIC EFFECTS :
Musculoskeletal - joints
REFERENCE :
BJRHDF British Journal of Rheumatology. (Bailliere Tindall, 33 The Avenue,
Eastborn BN21 3UN, UK) Volume(issue)/page/year: 33,674,1994

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 730 mg/kg/1Y-I
TOXIC EFFECTS :
Behavioral - anorexia (human)
Gastrointestinal - nausea or vomiting
Liver - liver function tests impaired
REFERENCE :
AJGAAR American Journal of Gastroenterology. (American College of
Gastroenterology, Inc., 428 E. Preston St., Baltimore, MD 21202) V.21-
1954- Volume(issue)/page/year: 91,1641,1996

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 3100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al.,
eds., Washington, DC, American Soc. for Microbiology, 1978
Volume(issue)/page/year: 1,501,1978

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 310 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al.,
eds., Washington, DC, American Soc. for Microbiology, 1978
Volume(issue)/page/year: 1,501,1978

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 140 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al.,
eds., Washington, DC, American Soc. for Microbiology, 1978
Volume(issue)/page/year: 1,501,1978

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intracerebral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 38 mg/kg
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions
Behavioral - excitement
Musculoskeletal - changes in teeth and supporting structures
REFERENCE :
CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New
York, NY 10003) V.13- 1968- Volume(issue)/page/year: 26,196,1980

** MUTATION DATA **

TYPE OF TEST : DNA inhibition
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 3750 ug/L
REFERENCE :
BCPHBM British Journal of Clinical Pharmacology. (Blackwell Scientific Pub.
Ltd., POB 88, Oxford, UK) V.1- 1974- Volume(issue)/page/year:
16,127,1983

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X3732
No. of Facilities: 13 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 7704 (estimated)
No. of Female Employees: 7190 (estimated)


*** END OF RECORD ***
Search More   
ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Myxovalargin A 82658-75-1
Myxovalargin B 85568-63-4
4-Morpholinepropanamine,N-(5-chloro-2-nitrobenzo(b)thien-3-yl)- 149338-22-7
Myxovalargin C 85568-64-5
Myxovalargin D 85568-65-6
Naematolin 11054-16-3
Nagase (bacillus subtilis) 11054-16-3
Najatoxin 11054-16-3
Named reagents and solutions, cpd 39374-34-0
4a-epi-Nanaomycin B 72691-97-5
Nandina domestica Thunb., stem extractSUBSTANCE DEFINITION :Plant containing berberine-type alkaloidsREFERENCE :YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881-Volume(issue)/page/year: 82,726,1962 72691-97-5
Naphth(2,3-a)aceanthrylene 84030-79-5
Naphthacene 92-24-0
4-Morpholinepropanamine,N-(3-chlorophenyl)-2,6-dimethyl-N-4-pyridinyl-,mono(2-hydroxybenzoate) 59235-63-1
2-Naphthacenecarboxamide,N-((4-(amidinoamidino)-1-piperazinyl)methyl)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-di oxo- 16545-11-2
2-Naphthacenecarboxamide,N-((4-(amidinoamidino)-1-piperazinyl)methyl)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-diox o-, dihydrochloride 13040-98-7
2-Naphthacenecarboxamide,4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a- tetrahydroxy-1,11-dioxo- 10118-90-8
2-Naphthacenecarboxamide,4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a- tetrahydroxy-1,11-dioxo-,(4S-(4-alpha,4a-alpha,5a-alpha,12a-alpha))-,disulfate (1:2) (salt) 10118-90-8
2-Naphthacenecarboxamide,4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a- tetrahydroxy-1,11-dioxo-,monohydrochloride 13614-98-7
2-Naphthacenecarboxamide,7-bromo-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10- 12,12a-pentahydroxy-6-methyl-1,11-dioxo- 4572-56-9
2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,2,3,4,4a,5,5a,6,11,12a-decahydro-1,11-dioxo-N-(hydroxymethyl)-6-methyl-3,6,10,12,12a-pentahydroxy- 1181-54-0
2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro- 3,6,10,12,12a-pentahydroxy-1,11-dioxo- 127-33-3
2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro- 3,6,10,12,12a-pentahydroxy-1,11-dioxo-,monohydrochloride 64-73-3
2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro- 3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo- 57-62-5
4-Morpholinepropanamine,N-(3-chlorophenyl)-beta-methyl-N-4-pyridinyl-, (Z)-2-butenedioate (1:2) 21957-74-4
2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,monohydrochloride 64-72-2
2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo- 2013-58-3
2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a- hexahydroxy-6-methyl-1,11-dioxo-,(4S-(4-alpha,4a-alpha,5-alpha,5a-alpha,6-beta,12a-alpha))- 79-57-2
2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-,calcium salt (1:1),(4S-(4-alpha,4a-alpha,5-alpha,5a-alpha,6-beta,12a-alpha))- 7179-50-2
2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12, 12a-hexahydroxy-6-methyl-1,11-dioxo-,disodium deriv., dihydrate 6153-65-7
2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a- hexahydroxy-6-methyl-1,11-dioxo-,monohydrochloride 2058-46-0
2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-2,5,6,10,12,12a- hexahydroxy-6-methyl-1,11-dioxo-,monohydrochloride, mixed with potassium nitrite 2058-46-0
2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a- hexahydroxy-6-methyl-1,11-dioxo-, compd.with sodium nitrite (1:3) 2058-46-0
2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a- hexahydroxy-6-methyl-1,11-dioxo-, sodiumsalt 69766-62-7
2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12, 12a-hexahydroxy-6-methyl-1,11-dioxo-,sulfate 64038-91-1
4-Morpholinepropanamine,N-(3-chlorophenyl)-N-4-pyridinyl-,bis(2-hydroxybenzoate) 21928-15-4
2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-N-((4-(2-hydroxyethyl)-1-piperazinyl)methyl)-6-methyl-1,11-di oxo- 1110-80-1
2-Naphthacenecarboxamide,4-alpha-S-(dimethylamino)-1,4,4a-alpha-5,5a-alpha,6,11,12a-octahydro-3,5-alpha,10,12,12a-alpha-pentahydroxy-6-alpha-methyl-1,11-dioxo- 564-25-0
2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a- pentahydroxy-6-methyl-1,11-dioxo- 60-54-8
2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,monohydrochloride 10592-13-9
2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a- pentahydroxy-6-methyl-1,11-dioxo-,monohydrochloride 64-75-5
2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-N-(1-pyrrolidinylmethyl)- 751-97-3
2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-N-(1-pyrrolidinylmethyl)-, mononitrate (salt) 20685-78-3
2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a- pentahydroxy-6-methyl-1,11-dioxo-,(4S-(4-alpha,4a-alpha,5a-alpha,6-beta,12a-alpha))-,compd. with 4-hydroxy-3-methoxybenzenesulfonate (1:1) 20228-26-6
2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo- 914-00-1
2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a- pentahydroxy-6-methylene-1,11-dioxo-,monohydrochloride 3963-95-9
4-Morpholinepropanamine,N-(3-chlorophenyl)-N-4-pyridinyl-beta,2,6-trimethyl-,mono(2-hydroxybenzoate) 23410-76-6
2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-9-(morpholinomethyl)-1,11-dioxo- 67238-91-9
2-Naphthacenecarboxamide,N,N'-(ethylenebis((methylimino)methylene))bis(4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-di oxo- 17910-68-8
2-Naphthacenecarboxamide,1,4,4a,5,12,12a-hexahydro-4-(dimethylamino)-1,12-dioxo-6-methyl- 3,10,11,12a-tetrahydroxy-,(4S-(4-alpha,4a-alpha,12a-alpha))- 1665-56-1

Free MSDS Search ( Providing 250,000+ Material Properties )
Chemcas.com| Ads link:todaystock.net