RTECS NUMBER : QJ5800000
CHEMICAL NAME : 1,4-Naphthalenedione,
2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-
CAS REGISTRY NUMBER : 84-80-0
LAST UPDATED : 199701
DATA ITEMS CITED : 7
MOLECULAR FORMULA : C31-H46-O2
MOLECULAR WEIGHT : 450.77
WISWESSER LINE NOTATION : L66 BV EVJ C1 D2UY1&3Y1&3Y1&3Y1&1
COMPOUND DESCRIPTOR : Drug
Human
SYNONYMS/TRADE NAMES :
* Antihemorrhagic vitamin
* Aqua mephyton
* Combinal K1
* Kativ N
* Kephton
* Kinadion
* Konakion
* Mephyton
* 2-Methyl-3-phytyl-1,4-naphthochinon
* 2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione
* 1,4-Naphthoquinone, 2-methyl-3-phytyl-
* Monodion
* Mono-kay
* Phyllochinon
* Phylloquinone
* alpha-Phylloquinone
* trans-Phylloquinone
* Phytomenadione
* Phytonadione
* Vitamin K1
* Synthex P
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Human - man
DOSE/DURATION : 11429 ug/kg/8D-I
TOXIC EFFECTS :
Blood - eosinophilia
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
ARDEAC Archives of Dermatology. (AMA, 535 N. Dearborn St., Chicago, IL
60610) V.82- 1960- Volume(issue)/page/year: 121,1421,1985
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >33487 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and
Trademark Office, Foreign Patents, Washington, DC 20231)
Volume(issue)/page/year: #2808572
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 25 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 17,1339,1967
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 8,25,1958
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >6570 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,653,1982
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4073
No. of Facilities: 394 (estimated)
No. of Industries: 4
No. of Occupations: 23
No. of Employees: 26120 (estimated)
No. of Female Employees: 15615 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***
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