*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : QM2450000
CHEMICAL NAME : 2-Naphthylamine, N,N-bis(2-chloroethyl)-
CAS REGISTRY NUMBER : 494-03-1
BEILSTEIN REFERENCE NO. : 3316600
REFERENCE : 4-12-00-03126 (Beilstein Handbook Reference)
LAST UPDATED : 199612
DATA ITEMS CITED : 21
MOLECULAR FORMULA : C14-H15-Cl2-N
MOLECULAR WEIGHT : 268.20
WISWESSER LINE NOTATION : L66J CN2G2G
COMPOUND DESCRIPTOR : Tumorigen
Drug
Mutagen
Human
SYNONYMS/TRADE NAMES :
* N,N-Bis-(2-chlorethyl)-2-naftylamin
* 2-Bis(2-chloroethyl)aminonaphthalene
* N,N,-Bis(2-chloroethyl)-2-naphthylamine
* Bis(2-chloroethyl)-beta-naphthylamine
* Chlornaftina
* Chlornaphazin
* Chlornaphazine
* Chlornaphthin
* Chloronaftina
* Chloronaphthine
* Dichloroethyl-beta-naphthylamine
* Di(2-chloroethyl)-beta-naphthylamine
* N,N-Di(2-chloroethyl)-beta-naphthylamine
* 2-N,N-Di(2-chloroethyl)naphthylamine
* Erysan
* Naphthylamine mustard
* beta-Naphthyl-bis-(beta-chloroethyl)amine
* 2-Naphthylbis(2-chloroethyl)amine
* beta-Naphthyl-di-(2-chloroethyl)amine
* NSC-62209
* R48
* RCRA waste number U026
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1086 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year:
13,969,1964
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ONRAAQ Oncologia si Radiologia. (Bucharest, Romania) V.1-13(3), 1962-74.
For publisher information, see ONCODU. Volume(issue)/page/year: 5,443,1966
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 2468 mg/kg/6Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - tumors
REFERENCE :
AMSVAZ Acta Medica Scandinavica. (Almqvist & Wiksell, POB 45150, S-10430
Stockholm, Sweden) V.52-224, 1919-88. Volume(issue)/page/year: 176,45,1964
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 3132 mg/kg/10Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - tumors
REFERENCE :
AMSVAZ Acta Medica Scandinavica. (Almqvist & Wiksell, POB 45150, S-10430
Stockholm, Sweden) V.52-224, 1919-88. Volume(issue)/page/year: 176,45,1964
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 3200 mg/kg/11Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - tumors
REFERENCE :
AMSVAZ Acta Medica Scandinavica. (Almqvist & Wiksell, POB 45150, S-10430
Stockholm, Sweden) V.52-224, 1919-88. Volume(issue)/page/year: 175,721,1964
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 330 mg/kg/4W
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60,
1940-78. For publisher information, see JJIND8. Volume(issue)/page/year:
36,915,1966
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 4090 mg/kg/7Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - tumors
REFERENCE :
AMSVAZ Acta Medica Scandinavica. (Almqvist & Wiksell, POB 45150, S-10430
Stockholm, Sweden) V.52-224, 1919-88. Volume(issue)/page/year: 176,45,1964
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 3200 mg/kg/11Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - tumors
REFERENCE :
AMSVAZ Acta Medica Scandinavica. (Almqvist & Wiksell, POB 45150, S-10430
Stockholm, Sweden) V.52-224, 1919-88. Volume(issue)/page/year: 185,133,1969
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 20 ug/plate
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
37,2209,1977
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 10 ug/plate
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.1- 1915-
Volume(issue)/page/year: 72,5135,1975
TYPE OF TEST : Specific locus test
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 2600 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
30,195,1970
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 2600 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
30,195,1970
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - hamster Embryo
DOSE/DURATION : 120 ug/L
REFERENCE :
AETODY Advances in Modern Environmental Toxicology. (Senate Press, Inc.,
P.O. Box 252, Princeton Junction, NJ 08550) V.1- 1980-
Volume(issue)/page/year: 1,241,1980
*** REVIEWS ***
IARC Cancer Review:Human Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 4,119,1974
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 4,119,1974
IARC Cancer Review:Group 1
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,130,1987
TOXICOLOGY REVIEW
ADCSAJ Advances in Chemistry Series. (American Chemical Soc., Distribution
Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1-
1950- Volume(issue)/page/year: 13,271,1970
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; Histidine
reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
Deleted from 6th Annual Report. reason: no U.S. residents exposed
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Naphtho(1,2-b)thiopyrylium,5,6-dihydro-2,4-diphenyl-, iodide
| 65193-68-2 |
Naphtho(1,2-b)thiopyrylium,5,6-dihydro-2,4-diphenyl-, perchlorate
| 65193-67-1 |
Naphtho(1,2-b)thiopyrylium, 5,6-dihydro-2,4-diphenyl-trifluoroacetate
| 65193-67-1 |
Naphtho(1,2-b)thiopyrylium,5,6-dihydro-2,4-diphenyl-, salt with trifluoroaceticacid (1:1)
| 65193-66-0 |
Naphtho(1,2-b)thiopyrylium,5,6-dihydro-2-(p-methoxyphenyl)-4-phenyl-,trifluoroacetate
| 65193-66-0 |
Naphtho(1,2-b)thiopyrylium,5,6-dihydro-4-(p-methoxyphenyl)-2-phenyl-,trifluoroacetate
| 65193-66-0 |
1H-Naphtho(2,3-d)triazole-4,9-dione, 6,7-dimethyl-
| 72364-91-1 |
2H-Naphtho(1,2-d)triazole-6,8-disulfonic acid,2-(4'-amino-1,1'-biphenyl-4-yl)-, dipotassium salt
| 74039-01-3 |
2H-Naphtho(1,2-d)triazole-6,8-disulfonic acid,2-(4'-amino-3'-sulfo-1,1'-biphenyl-4-yl)-,tripotassium salt
| 74039-02-4 |
3H-Naphtho(1,2-d)triazolium, 1,3-dimethyl-, chloride
| 74039-02-4 |
1-Naphthoic acid, 1,4-dihydro-, 2-(diethylamino)ethylester, hydrochloride
| 67293-09-8 |
3H-Naphtho(1,2-d)triazolium, 2,3-dimethyl-, chloride
| 67293-09-8 |
3H-Naphtho(1,2-d)triazolium, 1,3-dimethyl-, iodide
| 67293-09-8 |
3H-Naphtho(1,2-d)triazolium, 2,3-dimethyl-, iodide
| 67293-09-8 |
3H-Naphtho(1,2-d)triazolium, 2,3-diphenyl-, chloride
| 67293-09-8 |
2H-Naphth(1,2-b)-1,5-oxazocin-3-ol,3,4-dihydro-6-methyl-
| 27827-70-9 |
Naphth(1,2-b)oxirene-2,3-diol, 1a,2,3,7b-tetrahydro-,(1a-alpha,2-alpha,3-beta,7b-alpha)-
| 69222-27-1 |
Naphth(1,2-b)oxirene-2,3-diol, 1a,2,3,7b-tetrahydro-,(1a-alpha,2-beta,3-alpha,7b-alpha)-
| 69222-28-2 |
Naphth(2,3-b)oxirene-2,7-dione,7a-(3,7-dimethyl-2,6-octadienyl)-1a,7a-dihydro-3,5-dihydroxy- 4-methyl-1a-(3-methyl-2-butenyl)-,(1a-alpha,7a-alpha(E))-(+)-
| 110200-30-1 |
Naphth(2,3-b)oxirene-2,4,7(3H)-trione,1a,7a-dihydro-3-diazo-1a-(3,7-dimethyl-2,6-octadienyl)-6-hydroxy-5-methyl- 7a-(3-methyl-2-butenyl)-,(1a-alpha(E),7a-alpha)-(+)-
| 110200-31-2 |
Naphth(1,2-b)oxiren-2(1ah)-one,4,5,6,7,7a,7b-hexahydro-7,7a-dimethyl-6-hydroxy-1a-(2-(hydroxymethyl)oxiranyl)-
| 85431-61-4 |
1-Naphthoic acid, 2,3-dihydroxy-
| 16715-77-8 |
1-Naphthylamine
| 134-32-7 |
2-Naphthylamine
| 91-59-8 |
1-Naphthylamine, acetate
| 91-59-8 |
2-Naphthylamine, N-(L-alanyl)-1,2,3,4-tetrahydro-
| 14329-69-2 |
1-Naphthylamine, N-(5-amino-2-oxazolyl)-
| 102280-40-0 |
2-Naphthylamine, N,N-bis(2-chloroethyl)-
| 494-03-1 |
1-Naphthylamine,N,N-bis(2-chloroethyl)-4-methoxy-3-methyl-
| 17692-54-5 |
1-Naphthylamine, 2-bromo-N-(2-imidazolin-2-yl)-,hydrobromide
| 102280-41-1 |
1-Naphthylamine, 4-bromo-N-(2-imidazolin-2-yl)-,hydrochloride
| 102280-42-2 |
1-Naphthylamine,4-chloro-N-(5,6-dihydro-4H-1,3-thiazin-2-yl)-
| 102280-43-3 |
1-Naphthoic acid, 2-(dimethylamino)ethyl ester,hydrochloride
| 50310-44-6 |
1-Naphthylamine, decahydro-N-(2-oxazolin-2-yl)-
| 100531-21-3 |
1-Naphthylamine, 2,4-dibromo-N-(2-imidazoline-2-yl)-,hydrobromide
| 102280-44-4 |
1-Naphthylamine, 5,8-dichloro-
| 3604-99-7 |
2-Naphthylamine, 5,6-dimethoxy-
| 23922-96-5 |
2-Naphthylamine, 5,6-dimethoxy-N,N-dimethyl-
| 23923-03-7 |
2-Naphthylamine, 5,6-dimethoxy-N-methyl-
| 23923-00-4 |
1-Naphthylamine, N,N-dimethyl-
| 86-56-6 |
2-Naphtylamine, mixed with(alpha,alpha-dimethylbenzyl)hydroperoxide
| 86-56-6 |
2-Naphthylamine,N-ethyl-1-((p-(phenylazo)phenyl)azo)-
| 6368-72-5 |
2-Naphthylamine, N-ethyl-1,2,3,4-tetrahydro-
| 19485-86-0 |
Naphtho(2,3-b)furan, 5,6,7,8-tetrahydro-2-nitro-
| 86295-47-8 |
2-Naphthoic acid, 3-ethoxy-, 3-(diethylamino)propylester, hydrochloride
| 110331-08-3 |
2-Naphthylamine,N-(2-fluoroethyl)-N-(2-methoxyethyl)-
| 15314-55-3 |
1-Naphthylamine hydrochloride
| 552-46-5 |
2-Naphthylamine, hydrochloride
| 612-52-2 |
1-Naphthylamine, N-(2-imidazolin-2-yl)-
| 4751-46-6 |
2-Naphthylamine, 1-methoxy-
| 3178-03-8 |
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