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MSDS  : 1,4-Naphthoquinone, 2-methyl-
CAS  : 58-27-5
SYNONYMS  : * Aquakay * Aquinone * Hemodal * Juva-K * Kaergona * Kanone * Kappaxan * Kappaxin * Karcon * Kareon * Kativ-G * Kayklot * Kaykot * Kayquinone * Kipca * Kipca, oil soluble * Klottone * Koaxin * Kolklot * K-Thrombyl * K-Vitan * Memodol * Menadion * Menadione * Menaphthon * Menaphthone * Menaquinone * Menaquinone 0 * Menaphtone * 2-Methyl-1,4-naftochinon * 2-Methyl-1,4-naphthalenedione * 2-Methyl-1,4-naphthochinon * 2-Methyl-1,4-naphthoquinone * 3-Methyl-1,4-naphthoquinone * Mitenon * Mitenone * MNQ * 1,4-Naphthalenedione, 2-methyl- * NSC 4170 * Panosine * Prokayvit * Synkay * Thyloquinone * USAF EK-5185 * Vitamin K2(0) * Vitamin K3
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : QL9100000
CHEMICAL NAME : 1,4-Naphthoquinone, 2-methyl-
CAS REGISTRY NUMBER : 58-27-5
LAST UPDATED : 199710
DATA ITEMS CITED : 30
MOLECULAR FORMULA : C11-H8-O2
MOLECULAR WEIGHT : 172.19
WISWESSER LINE NOTATION : L66 BV EVJ C1
COMPOUND DESCRIPTOR : Tumorigen
Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Aquakay
* Aquinone
* Hemodal
* Juva-K
* Kaergona
* Kanone
* Kappaxan
* Kappaxin
* Karcon
* Kareon
* Kativ-G
* Kayklot
* Kaykot
* Kayquinone
* Kipca
* Kipca, oil soluble
* Klottone
* Koaxin
* Kolklot
* K-Thrombyl
* K-Vitan
* Memodol
* Menadion
* Menadione
* Menaphthon
* Menaphthone
* Menaquinone
* Menaquinone 0
* Menaphtone
* 2-Methyl-1,4-naftochinon
* 2-Methyl-1,4-naphthalenedione
* 2-Methyl-1,4-naphthochinon
* 2-Methyl-1,4-naphthoquinone
* 3-Methyl-1,4-naphthoquinone
* Mitenon
* Mitenone
* MNQ
* 1,4-Naphthalenedione, 2-methyl-
* NSC 4170
* Panosine
* Prokayvit
* Synkay
* Thyloquinone
* USAF EK-5185
* Vitamin K2(0)
* Vitamin K3

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
18,185,1971

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 43,125,1940

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD691-490

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 138 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 75,111,1942

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 230 mg/kg
TOXIC EFFECTS :
Vascular - other changes
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 75,111,1942

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 43,125,1940

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10500 mg/kg/30D-I
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells
Blood - changes in erythrocyte (RBC) count
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 43,125,1940

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 775 mg/kg/6D-I
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells
Blood - changes in spleen
Nutritional and Gross Metabolic - changes in iron
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
Volume(issue)/page/year: 11,85,1991

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1860 mg/kg/27W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
Tumorigenic - tumors at site of application
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year:
7,482,1953

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 8400 mg/kg/21W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
19,413,1959

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 3 gm/kg
SEX/DURATION : female 1-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year:
69,285,1973

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE : 20 mg/kg
SEX/DURATION : female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University.
(Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,
Japan) V.1- 1954- Volume(issue)/page/year: 8,175,1961

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 4 ug/plate
REFERENCE :
ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050,
Tokyo International, Tokyo 100-31, Japan) V.25- 1961-
Volume(issue)/page/year: 45,327,1981

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 30 nmol/plate
REFERENCE :
BBRCA9 Biochemical and Biophysical Research Communications. (Academic
Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
Volume(issue)/page/year: 94,737,1980

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 6 ppm
REFERENCE :
POASAD Proceedings of the Oklahoma Academy of Science. (Oklahoma Academy of
Science, c/o Executive Secretary-Treasurer, Southwestern Oklahoma State
Univ., Weatherford, OK 73096) V.1- 1910/1920- Volume(issue)/page/year:
34,114,1953

TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 2500 nmol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year:
21,249,1972

TYPE OF TEST : Specific locus test
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 360,145,1996

TYPE OF TEST : DNA damage
TEST SYSTEM : Human Fibroblast
DOSE/DURATION : 20 umol/L
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 28,37,1985

TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - hamster Cells - not otherwise specified
DOSE/DURATION : 15 umol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year:
42,1961,1991

TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 10 nmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
49,5239,1989

TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 10 umol/L
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 28,37,1985

TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - mouse Embryo
DOSE/DURATION : 750 ug/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 16,477,1995

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 2 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 249,7,1991

TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 10 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 178,57,1987

*** REVIEWS ***

TOXICOLOGY REVIEW
JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial
Dr., St. Louis, MO 63141) V.1- 1932- Volume(issue)/page/year: 59,1,1961

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84779
No. of Facilities: 63 (estimated)
No. of Industries: 2
No. of Occupations: 6
No. of Employees: 1170 (estimated)

NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84779
No. of Facilities: 771 (estimated)
No. of Industries: 5
No. of Occupations: 16
No. of Employees: 6103 (estimated)
No. of Female Employees: 2166 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA Section 8(d) unpublished health/safety studies

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
1,4-Naphthoquinone, 2-hydroxy-3-methyl- 483-55-6
1,4-Naphthoquinone, 5-hydroxy-2-methyl- 481-42-5
1,4-Naphthoquinone, 5-hydroxy-7-methyl- 14787-38-3
1,4-Naphthoquinone, 2-hydroxy-3-(3-methyl-2-butenyl)- 84-79-7
1,4-Naphthoquinone, 2-hydroxy-3-(2-methyloctyl)- 3568-91-0
1-Naphthoic acid, 3-amino-,(2-dimethyl-3-(dimethylamino)propyl) ester,hydrochloride 3568-91-0
1,4-Naphthoquinone, 2-hydroxy-3-(2-methyloctyl)-,sodium salt 3568-91-0
1,4-Naphthoquinone, 2-(isopropylamino)- 57950-03-5
1,4-Naphthoquinone, 2-methoxy- 2348-82-5
Naphthoquinone, methyl- 72060-21-0
1,4-Naphthoquinone, 2-methyl- 58-27-5
1,4-Naphthoquinone,2-(3-(4-methyl-1-piperazinyl)propylamino)- 38528-40-4
1,4-Naphthoquinone, 2-methyl-, sodium bisulfite,trihydrate 57414-02-5
1,4-Naphthoquinone,2-methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)- 863-61-6
1,2-Naphthoquinone, 2-(4-phenylsemicarbazono)- 863-61-6
1,4-Naphthoquinone, 2-(3-piperidinopropyl)amino- 38528-39-1
1-Naphthoic acid, 4-amino-,(2-dimethyl-3-(dimethylamino)propyl) ester,hydrochloride 38528-39-1
1,4-Naphthoquinone,2,2'-(sulfonylbis(p-phenyleneimino))bis(3-chloro- 6937-70-8
1,4-Naphthoquinone, 4a,5,8,8a-tetrahydro- 6271-40-5
2H-Naphtho(2,1-e)-1,2-thiazine-3-carboxamide,4-hydroxy-2-methyl-N-(4-methyl-2-pyridyl)-,1,1-dioxide 61764-15-6
Naphtho(1,2-d)thiazol-2-amine,4,5-dihydro-N-(2-(4-morpholinyl)ethyl)-,dihydrochloride 118707-60-1
Naphtho(2,3-d)thiazole,3a,4,4a,5,6,7,8,8a,9,9a-decahydro-2-phenyl-,(3a-alpha,4a-beta,8a-alpha,9a-alpha)- 96159-96-5
Naphtho(1,2-d)thiazole-1-propanesulfonic acid,2-(6-(3-(3-sulfopropyl)-4-oxo-2-thioxo-5-thiazolidinylene)-2,4-hexadienylidene)-, disodiumsalt 73816-85-0
Naphtho(1,2-d)thiazolium,2-(3-chloro-5-(1-ethylnaphtho(1,2-d)thiazolin-2-ylidene-1,3- pentadienyl)-1-ethyl)-, iodide 20682-19-3
Naphtho(1,2-d)thiazolium,2-(p-dimethylaminostyryl)-1-methyl-, iodide 6285-35-4
Naphtho(1,2-d)thiazolium,1-ethyl-2-((1-ethylnaphtho(1,2-d)thiazolin-2-ylidene)methyl)-, iodide 18474-32-3
Naphtho(1,2-d)thiazolium,1-ethyl-2-(3-(1-ethylnaphtho(1,2-d)thiazolin-2-ylidene)propenyl)-, iodide 18359-88-1
1-Naphthoic acid, (o-bromobenzoyl)hydrazide 73826-60-5
Naphtho(1,2-b)thiophene 234-41-3
2H-Naphtho(1,8-bc)thiophene 209-11-0
Naphtho(2,1-b)thiophene-6,9-diol,1,2,5,9b-tetrahydro-8-((2-(acetyloxy)ethyl)thio)-4-methyl-, diacetate, 3,3-dioxide 125220-00-0
Naphtho(2,1-b)thiophene-6,9-dione,1,2,5,5a,9a,9b-hexahydro-8-((2-hydroxyethyl)thio)-4-methyl-, 3,3-dioxide 125219-99-0
Naphtho(2,1-b)thiophene-6,9-dione,1,2,5,9b-tetrahydro-4-methyl-, 3,3-dioxide 125219-84-3
Naphtho(2,1-b)thiophene-4-methanol,8-bromo-alpha-((dibutylamino)methyl)-, hydrochloride 37094-62-5
Naphtho(2,1-b)thiophene-4-methanol,alpha-((dibutylamino)methyl)-, hydrochloride 37094-60-3
Naphtho(2,1-b)thiophene-4-methanol,alpha-((dibutylamino)methyl)-8-(trifluoromethyl)-,hydrochloride 52368-39-5
Naphtho(2,3-c)thiophen-1(3H)-one,3-((dimethylamino)methyl)-, hydrochloride 97874-47-0
Naphtho(2,1-b)thiophen-1(2H)-one,2-(1-oxonaphtho(2,1-b)thien-2(1H)-ylidene)- 3989-75-1
1-Naphthoic acid, (m-chlorobenzoyl)hydrazide 101931-49-1
4H-Naphtho(1,2-b)thiopyran,5,6-dihydro-4-(3,4-dimethoxyphenyl)-2-phenyl- 101931-49-1
1H-Naphtho(2,1-b)thiopyran, 5,6-dihydro-2,4-diphenyl- 101931-49-1
4H-Naphtho(1,2-b)thiopyran, 5,6-dihydro-2,4-diphenyl- 65193-63-7
4H-Naphtho(1,2-b)thiopyran,5,6-dihydro-4-(p-methoxyphenyl)-2-phenyl- 65193-63-7
2H-Naphtho(1,2-b)thiopyran,3,4,4a,5,6,10b-hexahydro-4-(3,4-dimethoxyphenyl)-2-phenyl- 65193-63-7
1H-Naphtho(2,1-b)thiopyran,2,3,4a,5,6,10b-hexahydro-1,3-diphenyl- 65193-63-7
2H-Naphtho(1,2-b)thiopyran,3,4,4a,5,6,10b-hexahydro-2,4-diphenyl- 65193-64-8
2H-Naphtho(1,2-b)thiopyran,3,4,4a,5,6,10b-hexahydro-4-(p-methoxyphenyl)-2-phenyl- 65193-64-8
Naphtho(1,2-b)thiopyrylium,5,6-dihydro-2,4-bis(p-methoxyphenyl)-,trifluoroacetate 65193-64-8
Naphtho(1,2-b)thiopyrylium,5,6-dihydro-4-(3,4-dimethoxyphenyl)-2-phenyl-,trifluoroacetate 65193-64-8
1-Naphthoic acid, 2-(diethylamino)ethyl ester,hydrochloride 63979-15-7

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