RTECS NUMBER : QU3340000
CHEMICAL NAME : Nisin
CAS REGISTRY NUMBER : 1414-45-5
LAST UPDATED : 199512
DATA ITEMS CITED : 3
MOLECULAR FORMULA : C143-H230-N42-O37-S7
MOLECULAR WEIGHT : 3354.57
COMPOUND DESCRIPTOR : Drug
Natural Product
SYNONYMS/TRADE NAMES :
* NSC-112903
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca
Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 4(2),228,1980
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 2250 ug/kg
TOXIC EFFECTS :
Brain and Coverings - meningeal changes
Brain and Coverings - changes in cerebral spinal fluid
Behavioral - irritability
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK)
V.1-33, 1946-68. For publisher information, see BJPCBM.
Volume(issue)/page/year: 7,438,1952
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 290 mg/kg/18D-I
TOXIC EFFECTS :
Vascular - thrombosis distant from injection site
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK)
V.1-33, 1946-68. For publisher information, see BJPCBM.
Volume(issue)/page/year: 7,438,1952
*** END OF RECORD ***
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