RTECS NUMBER : RH0175000
CHEMICAL NAME : Octanoic acid
CAS REGISTRY NUMBER : 124-07-2
BEILSTEIN REFERENCE NO. : 1747180
REFERENCE : 4-02-00-00982 (Beilstein Handbook Reference)
LAST UPDATED : 199710
DATA ITEMS CITED : 13
MOLECULAR FORMULA : C8-H16-O2
MOLECULAR WEIGHT : 144.24
WISWESSER LINE NOTATION : QV7
COMPOUND DESCRIPTOR : Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Hexacid 898
* C-8 acid
* Caprylic acid
* n-Caprylic acid
* neo-Fat 8
* 1-Heptanecarboxylic acid
* Kyselina kaprylova
* Octic acid
* n-Octoic acid
* n-Octylic acid
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/24H
REACTION SEVERITY : Moderate
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 19,237,1981
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10080 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 600 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
18,141,1961
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 19,237,1981
** MUTATION DATA **
TYPE OF TEST : Sex chromosome loss and nondisjunction
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 5 ppm
REFERENCE :
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of
Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-
Volume(issue)/page/year: 407,186,1983
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Non-mammalian species Cells - not otherwise specified
DOSE/DURATION : 10 mmol/L
REFERENCE :
CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.1- 1939- Volume(issue)/page/year:
40,1,1973
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Non-mammalian species Cells - not otherwise specified
DOSE/DURATION : 10 mmol/L
REFERENCE :
CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.1- 1939- Volume(issue)/page/year:
40,1,1973
*** REVIEWS ***
TOXICOLOGY REVIEW
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year: 21,100,1960
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84154
No. of Facilities: 939 (estimated)
No. of Industries: 15
No. of Occupations: 25
No. of Employees: 22322 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84154
No. of Facilities: 21067 (estimated)
No. of Industries: 146
No. of Occupations: 97
No. of Employees: 222149 (estimated)
No. of Female Employees: 8182 (estimated)