*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : RC9030000
CHEMICAL NAME : 19-Nor-17-alpha-pregn-4-en-20-yn-3-one, 17-hydroxy-,
mixed with 19-nor-17-alpha-pregna-
1,3,5(10)-trien-20-yne-3,17-diol
CAS REGISTRY NUMBER : 37270-71-6
LAST UPDATED : 199506
DATA ITEMS CITED : 16
MOLECULAR FORMULA : C20-H26-O2.C20-H24-O2
MOLECULAR WEIGHT : 594.90
WISWESSER LINE NOTATION : L E5 B666TTT&J E1 FQ F1UU1 OQ &L E5 B666 OV MUTJ E1
FQ F1UU1
COMPOUND DESCRIPTOR : Tumorigen
Drug
Mutagen
Reproductive Effector
Human
Hormone
SYNONYMS/TRADE NAMES :
* Binovum
* Brevicon
* Brevinor
* DT 5061
* DT 5062
* DT-5062(1/35)
* Duagynon
* E-Con
* Ethinylestradiol-norethisterone mixt.
* Ethynylestradiol mixed with norethindrone
* Gynovlar
* Modicon
* Neocon
* Netasyn
* Norethindron-ethinylestradiol mixt.
* Norethindrone mixed with ethynylestradiol
* Norethisterone-ethinylestradiol mixt.
* Norethisterone-ethynylestradiol mixt.
* Norethisterone mixed with ethinyl oestradiol
* Oestro-primolut
* Ortho-novum 7/7/7
* Ortho-novum 10/11
* Ovcon
* Ovcon 35
* Ovcon 50
* Ovysmen
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 55 mg/kg/5Y-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - nausea or vomiting
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
Volume(issue)/page/year: 1,1479,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 19(Suppl 4),S835,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 19(Suppl 4),S835,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : >2 gm/kg
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 19(Suppl 4),S835,1991
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 9737 ug/kg/52W-C
TOXIC EFFECTS :
Liver - other changes
Blood - changes in cell count (unspecified)
Nutritional and Gross Metabolic - changes in calcium
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 19(Suppl 4),S875,1991
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 138 mg/kg/9Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
Volume(issue)/page/year: 1,273,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 120 mg/kg/84W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
Endocrine - tumors
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:
154,402,1966
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 138 mg/kg/9Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year:
4,496,1975
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE : 420 ug/kg
SEX/DURATION : female 20 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1-
1970- Volume(issue)/page/year: 26,23,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Human - woman
DOSE : 63298 ug/kg
SEX/DURATION : female 11-34 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
Volume(issue)/page/year: 2,438,1960
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Human - woman
DOSE : 74682 ug/kg
SEX/DURATION : female 8-35 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
Volume(issue)/page/year: 2,438,1960
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 3745 ug/kg
SEX/DURATION : female 14 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 19(Suppl 4),S925,1991
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 10868 ug/kg
SEX/DURATION : female 14 day(s) pre-mating
female 1-7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 19(Suppl 4),S925,1991
** MUTATION DATA **
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Mammal - cattle Cells - not otherwise specified
DOSE/DURATION : 17410 ug/L
REFERENCE :
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-
Volume(issue)/page/year: 120,390,1974
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Mammal - domestic Cells - not otherwise specified
DOSE/DURATION : 17410 ug/L
REFERENCE :
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-
Volume(issue)/page/year: 120,390,1974
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Mammal - species unspecified Cells - not otherwise
specified
DOSE/DURATION : 10100 ug/L
REFERENCE :
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-
Volume(issue)/page/year: 120,390,1974
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Octadecanamide,N-(4-((4-(acetylamino)phenyl)sulfonyl)phenyl)-
| 124-26-5 |
Octadecanamide, N-antipyrinyl-
| 18503-71-4 |
Octadecanamide, N,N'-(1,1-biadamantane-3,3'-diyl)bis-
| 36546-27-7 |
19-Nor-17-alpha-pregn-4-en-20-yn-3-one, 17-hydroxy-,mixed with 19-nor-17-alpha-pregna-1,3,5(10)-trien-20-yne-3,17-diol
| 37270-71-6 |
Octadecanamide, N,N-dimethyl-
| 3886-90-6 |
Octadecanamide,N-((4-hydroxy-3-methoxyphenyl)methyl)-
| 58493-50-8 |
Octadecanamide,N-((4-hydroxy-3-methoxyphenyl)methyl)-9-methyl-,(+-)-
| 150988-83-3 |
Octadecanamide,N-((4-hydroxy-3-methoxyphenyl)methyl)-9-methylene-
| 96513-72-3 |
Octadecanamide, N,N'-methylenebis-
| 109-23-9 |
Octadecanamide, N,N'-1,4-phenylenebis-
| 16099-54-0 |
Octadecanamide, N-(4-phenyl-2-thiazolyl)-
| 71576-03-9 |
1-Octadecanaminium,N,N-dimethyl-N-(3-(trimethoxysilyl)propyl)-, chloride
| 27668-52-6 |
1-Octadecaneboronic acid
| 4445-09-4 |
1,18-Octadecanediamine, N,N'-bis(9-acridinyl)-
| 101858-26-8 |
19-Nor-17-alpha-pregn-4-en-20-yn-3-one, 17-hydroxy-,oxime
| 23965-86-8 |
Octadecanediamine, dihydrochloride
| 63906-90-1 |
9,12-Octadecadienamide, N-phenyl-, (Z,Z)-
| 19878-10-5 |
Octadecane, 1,18-dichloro-
| 19878-10-5 |
Octadecane, 1,18-difluoro-
| 408-43-5 |
Octadecane, 1-(ethenyloxy)-
| 930-02-9 |
Octadecanethioic acid,S-(4-(bis(2-chloroethyl)amino)phenyl) ester
| 67497-48-7 |
Octadecanethioic acid,S-(1-ethenyl-1H-pyrazolo(3,4-b)pyrazin-5-yl) ester
| 133280-18-9 |
Octadecanoic acid,1-(3-amino-3-oxopropyl)-2,2-dimethylhydrazide
| 96804-08-9 |
9-Octadecenoic acid (Z)-, bismuth(3+) salt
| 52951-38-9 |
Octadecanoic acid, cadmium salt
| 2223-93-0 |
19-Nor-17-alpha-pregn-4-en-20-yn-3-one, 17-hydroxy-,and premarin
| 2223-93-0 |
Octadecanoic acid, calcium salt, mixt. withepoxidized soybean oil and zinc dioctadecanoate
| 8064-81-1 |
Octadecanoic acid,2-(2-((dichloroacetyl)amino)-3-hydroxy-3-(4-nitrophenyl)propoxy)-2- oxoethyl ester, (R-(R*,R*))-
| 24292-47-5 |
Octadecanoic acid, 9,1012,13-diepoxy-
| 3012-69-9 |
Octadecanoic acid,(6,7-dihydro-4-methyl-7-(1-methylethenyl)-1-azulenyl)methyl ester
| 52898-98-3 |
Octadecanoic acid, 9,10-dihydroxy-, threo-
| 52898-98-3 |
Octadecanoic acid, 9,10-diiodo-, ethyl ester
| 52898-98-3 |
Octadecanoic acid,5-(dimethylamino)-2-(1-naphthalenyl)pentyl ester,hydrochloride
| 119585-30-7 |
9-Octadecenoic acid (Z)-, epoxidized, ester withpropylene glycol
| 68609-92-7 |
Octadecanoic acid, 9,10-epoxy-
| 2443-39-2 |
Octadecanoic acid, 9,10-epoxy-, cis-
| 24560-98-3 |
19-Nor-17-alpha-pregn-4-en-20-yn-3-one, 17-hydroxy-,propionate (ester), oxime
| 23965-88-0 |
Octadecanoic acid, 9,10-epoxy-, butyl ester
| 106-83-2 |
Octadecanoic acid, 9,10-epoxy-, cadmium salt (21)
| 106-83-2 |
Octadecanoic acid, 9,10-epoxy-, calcium salt (21)
| 106-83-2 |
Octadecanoic acid, 9,10-epoxy-,2,3-epoxy-2-ethylhexyl ester
| 63907-12-0 |
Octadecanoic acid, 9,10-epoxy-, 2-ethylhexyl ester
| 141-38-8 |
Octadecanoic acid, 9,10-epoxy-, magnesium salt
| 1876-02-4 |
Octadecanoic acid, 9-fluoro-
| 55797-34-7 |
Octadecanoic acid, 18-fluoro-
| 408-37-7 |
Octadecanoic acid, 18-fluoro-, methyl ester
| 463-29-6 |
Octadecanoic acid, 18-fluoro-10-methyl-, sodium salt
| 462-16-8 |
19-Nor-17-alpha-pregn-4-en-20-yn-3-one, 17-hydroxy-,and testosterone
| 462-16-8 |
Octadecanoic acid, 18-fluoro-, sodium salt
| 63907-11-9 |
Octadecanoic acid, ion(1-)
| 646-29-7 |
|
|