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MSDS  : 2-Pentanone, 4-hydroxy-4-methyl-
CAS  : 123-42-2
SYNONYMS  : * Diacetonalcohol * Diacetonalcool * Diacetonalkohol * Diacetone * Diacetone alcohol * Diacetone-alcool * Diketone alcohol * 4-Hydroxy-2-keto-4-methylpentane * 4-Hydroxy-4-methyl-pentan-2-on * 4-Hydroxy-4-methylpentanone-2 * 4-Hydroxy-4-methyl-2-pentanone * 4-Hydroxy-4-methyl pentan-2-one * 4-Hydroxy-4-methyl-2-pentanone * 4-Idrossi-4-metil-pentan-2-one * 2-Methyl-2-pentanol-4-one * Pyranton * Tyranton
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : SA9100000
CHEMICAL NAME : 2-Pentanone, 4-hydroxy-4-methyl-
CAS REGISTRY NUMBER : 123-42-2
BEILSTEIN REFERENCE NO. : 1740440
REFERENCE : 4-01-00-04023 (Beilstein Handbook Reference)
LAST UPDATED : 199712
DATA ITEMS CITED : 44
MOLECULAR FORMULA : C6-H12-O2
MOLECULAR WEIGHT : 116.18
WISWESSER LINE NOTATION : QX1&1&1V1
COMPOUND DESCRIPTOR : Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Diacetonalcohol
* Diacetonalcool
* Diacetonalkohol
* Diacetone
* Diacetone alcohol
* Diacetone-alcool
* Diketone alcohol
* 4-Hydroxy-2-keto-4-methylpentane
* 4-Hydroxy-4-methyl-pentan-2-on
* 4-Hydroxy-4-methylpentanone-2
* 4-Hydroxy-4-methyl-2-pentanone
* 4-Hydroxy-4-methyl pentan-2-one
* 4-Hydroxy-4-methyl-2-pentanone
* 4-Idrossi-4-metil-pentan-2-one
* 2-Methyl-2-pentanol-4-one
* Pyranton
* Tyranton

*** HEALTH HAZARD DATA ***

** SKIN/EYE IRRITATION DATA **

TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Human
DOSE/DURATION : 100 ppm/15M
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 28,262,1946

TYPE OF TEST : Open irritation test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 10 mg/24H
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 30,63,1948

TYPE OF TEST : Open irritation test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg
REACTION SEVERITY : Mild
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 6/29/1959

TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 20 mg
REACTION SEVERITY : Severe
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N.
Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
Volume(issue)/page/year: 29,1363,1946

** ACUTE TOXICITY DATA **

TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Human
DOSE/DURATION : 100 ppm
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - headache
Gastrointestinal - nausea or vomiting
REFERENCE :
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National
Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair
Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
Volume(issue)/page/year: 1,21,1974

TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Human
DOSE/DURATION : 400 ppm
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National
Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair
Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
Volume(issue)/page/year: 1,21,1974

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 30,63,1948

TYPE OF TEST : LC - Lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >1500 ppm/8H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 6/29/1959

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3024 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - coma
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 33,175,1928

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 3950 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see
JPMSAE. Volume(issue)/page/year: 45,669,1956

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 933 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd.,
San Romon, CA 94583) Volume(issue)/page/year: -,3,1961

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 4653 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 33,175,1928

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 13500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National
Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair
Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
Volume(issue)/page/year: 1,21,1974

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 2792 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 33,175,1928

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 2792 mg/kg
TOXIC EFFECTS :
Behavioral - coma
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 33,175,1928

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4494 mg/m3/6W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Blood - pigmented or nucleated red blood cells
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0536235

*** REVIEWS ***

ACGIH TLV-TWA 238 mg/m3 (50 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997

*** U.S. STANDARDS AND REGULATIONS ***

MSHA STANDARD-air:TWA 50 ppm (240 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,70,1971

OSHA PEL (Gen Indu):8H TWA 50 ppm (240 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994

OSHA PEL (Construc):8H TWA 50 ppm (240 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994

OSHA PEL (Shipyard):8H TWA 50 ppm (240 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993

OSHA PEL (Fed Cont):8H TWA 50 ppm (240 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994

*** OCCUPATIONAL EXPOSURE LIMITS ***

OEL-AUSTRALIA:TWA 50 ppm (240 mg/m3) JAN 1993

OEL-AUSTRIA:TWA 50 ppm (240 mg/m3) JAN 1993

OEL-BELGIUM:TWA 50 ppm (238 mg/m3) JAN 1993

OEL-DENMARK:TWA 50 ppm (240 mg/m3) JAN 1993

OEL-FINLAND:TWA 50 ppm (240 mg/m3);STEL 75 ppm (360 mg/m3) JAN 1993

OEL-FRANCE:TWA 50 ppm (240 mg/m3) JAN 1993

OEL-GERMANY:TWA 50 ppm (240 mg/m3) JAN 1993

OEL-THE NETHERLANDS:TWA 50 ppm (240 mg/m3) JAN 1993

OEL-THE PHILIPPINES:TWA 50 ppm (240 mg/m3) JAN 1993

OEL-RUSSIA:STEL 100 mg/m3 JAN 1993

OEL-SWITZERLAND:TWA 50 ppm (240 mg/m3) JAN 1993

OEL-TURKEY:TWA 50 ppm (240 mg/m3) JAN 1993

OEL-UNITED KINGDOM:TWA 50 ppm (240 mg/m3);STEL 75 ppm JAN 1993

OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV

OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO DIACETONE ALCOHOL-air:10H TWA 50 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M4016
No. of Facilities: 20435 (estimated)
No. of Industries: 191
No. of Occupations: 95
No. of Employees: 167915 (estimated)

NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M4016
No. of Facilities: 20857 (estimated)
No. of Industries: 194
No. of Occupations: 116
No. of Employees: 264662 (estimated)
No. of Female Employees: 67291 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA Section 8(d) unpublished health/safety studies

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

NIOSH Analytical Method, 1994: Alcohols III, 1402


*** END OF RECORD ***
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NAMECAS
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Phenanthridinium,3,8-bis(carboxyamino)-5,6-dimethyl-, methyl sulfate,diethyl ester 52705-84-7
Phenanthridinium,3,8-bis(carboxyamino)-5-ethyl-6-methyl-, ethylsulfate, diethyl ester 52705-84-7
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Phenanthridinium,3,8-bis(carboxyamino)-5-methyl-6-(nitrophenyl)-,methyl sulfate, diethyl ester 52705-84-7
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Phenanthridinium,6-(p-(carboxyamino)benzyl)-8-methoxy-5-methyl-,chloride, ethyl ester 102586-18-5
Phenanthridinium, 6-(p-carboxyaminobenzyl)-5-methyl-,chloride, ethyl ester 102586-18-5
Phenanthridinium,8-(carboxyamino)-6-(p-carboxyaminobenzyl)-5-methyl-,chloride, diethyl ester 102586-18-5
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Phenanthridinium,3-(carboxyamino)-6-(p-carboxyaminophenyl)-5-methyl-,chloride, diethyl ester 141809-36-1
Phenanthridinium, 3-(carboxyamino)-5,6-dimethyl-,bromide, ethyl ester 141809-36-1
Phenanthridinium, 8-(carboxyamino)-5,6-dimethyl-,methyl sulfate, ethyl ester 141809-36-1
Phenanthridinium,8-(carboxyamino)-5-methyl-6-(p-nitrobenzoyl)-,chloride, ethyl ester 141809-36-1
Phenanthridinium,3-(carboxyamino)-5-methyl-6-(p-nitrophenyl)-,chloride, ethyl ester 141809-36-1
Phenanthridinium,6-(p-(carboxyamino)phenyl)-8-hydroxy-5-methyl-,chloride, ethyl ester 141809-36-1
Phenanthridinium,6-(p-(carboxyamino)phenyl)-8-methoxy-5-methyl-,chloride, ethyl ester 141809-36-1
Phenanthridinium,6-(p-chlorophenyl)-3,8-diamino-5-methyl-, chloride 141809-36-1
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Phenanthridinium,6-(p-chlorophenyl)-8-methoxy-5-methyl-, chloride 141809-38-3
Phenanthridinium,3,8-diacetamido-5-methyl-6-(p-nitrophenyl)-, chloride 141809-38-3
Phenanthridinium, 3,8-diamino-5-butyl-6-phenyl-,bromide 141809-38-3
Phenanthridinium,3,8-diamino-5-(3-diethylaminopropyl)-6-phenyl-,methanesulfonate 141809-38-3
Phenanthridinium, 3,8-diamino-5,6-diethyl-, bromide 109641-04-5
Phenanthridinium,3,8-diamino-5-(3-(diethylmethylammonio)propyl)-6-phenyl-, diiodide 25535-16-4
Phenanthridinium,3,8-diamino-6-(p-(dimethylamino)styryl)-5-methyl-,methanesulfonate 25535-16-4
Phenanthridinium, 3,8-diamino-5,6-dimethyl-, bromide 32155-21-8
Phenanthridinium, 3,8-diamino-5,6-dimethyl-, methylsulfate 32155-21-8
Phenanthridinium,3,8-diamino-5-(2-ethoxyethyl)-6-phenyl-,methanesulfonate 32155-21-8
2-Pentanone, 4-hydroxy-4-methyl- 123-42-2
Phenanthridinium,3,8-diamino-5-(3-ethoxypropyl)-6-phenyl-,methanesulfonate 123-42-2

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