*** CHEMICAL IDENTIFICATION *** 
 
RTECS NUMBER            : SE9800000 
CHEMICAL NAME           : Phalloidin 
CAS REGISTRY NUMBER     : 17466-45-4 
OTHER CAS REGISTRY NOS. : 63-24-1 
BEILSTEIN REFERENCE NO. : 4347460 
LAST UPDATED            : 199612 
DATA ITEMS CITED        : 8 
MOLECULAR FORMULA       : C35-H48-N8-O11-S 
MOLECULAR WEIGHT        : 788.97 
COMPOUND DESCRIPTOR     : Mutagen 
                          Natural Product 
SYNONYMS/TRADE NAMES : 
   * Phalloidine 
  
                       *** HEALTH HAZARD DATA *** 
  
                        ** ACUTE TOXICITY DATA ** 
  
TYPE OF TEST            : LDLo - Lowest published lethal dose 
ROUTE OF EXPOSURE       : Intraperitoneal 
SPECIES OBSERVED        : Rodent - rat 
DOSE/DURATION           : 1 mg/kg 
TOXIC EFFECTS : 
   Details of toxic effects not reported other than lethal dose value 
REFERENCE : 
   TOXIA6 Toxicon.  (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, 
   UK)  V.1-    1962-  Volume(issue)/page/year: 10,357,1972 
  
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill 
ROUTE OF EXPOSURE       : Intraperitoneal 
SPECIES OBSERVED        : Rodent - mouse 
DOSE/DURATION           : 2 mg/kg 
TOXIC EFFECTS : 
   Details of toxic effects not reported other than lethal dose value 
REFERENCE : 
   NEJMAG New England Journal of Medicine.  (Massachusetts Medical Soc., 10 
   Shattuck St., Boston, MA 02115)  V.198-    1928-  Volume(issue)/page/year: 
   269,223,1963 
  
TYPE OF TEST            : LDLo - Lowest published lethal dose 
ROUTE OF EXPOSURE       : Intravenous 
SPECIES OBSERVED        : Rodent - mouse 
DOSE/DURATION           : 6600 ug/kg 
TOXIC EFFECTS : 
   Behavioral - muscle weakness 
   Liver - fatty liver degeneration 
REFERENCE : 
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und 
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher 
   information, see NSAPCC.  Volume(issue)/page/year: 190,406,1938 
  
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill 
ROUTE OF EXPOSURE       : Unreported 
SPECIES OBSERVED        : Rodent - mouse 
DOSE/DURATION           : 2 mg/kg 
TOXIC EFFECTS : 
   Details of toxic effects not reported other than lethal dose value 
REFERENCE : 
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag, 
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951- 
   Volume(issue)/page/year: 22,2142,1972 
  
TYPE OF TEST            : LD - Lethal dose 
ROUTE OF EXPOSURE       : Intravenous 
SPECIES OBSERVED        : Mammal - dog 
DOSE/DURATION           : >10 mg/kg 
TOXIC EFFECTS : 
   Details of toxic effects not reported other than lethal dose value 
REFERENCE : 
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000 
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year: 
   48,61,1981 
  
TYPE OF TEST            : LDLo - Lowest published lethal dose 
ROUTE OF EXPOSURE       : Oral 
SPECIES OBSERVED        : Mammal - species unspecified 
DOSE/DURATION           : 1000 ug/kg 
TOXIC EFFECTS : 
   Details of toxic effects not reported other than lethal dose value 
REFERENCE : 
   CTOXAO Clinical Toxicology.  (New York, NY)  V.1-18, 1968-81.  For publisher 
   information, see JTCTDW.  Volume(issue)/page/year: 17,45,1980 
  
                            ** MUTATION DATA ** 
  
TYPE OF TEST            : Morphological transformation 
TEST SYSTEM             : Rodent - rat Liver 
DOSE/DURATION           : 1 umol/L 
REFERENCE : 
   CYTZAM Cytobiologie.  (Stuttgart, Fed. Rep. Ger.)  V.1-18, 1969-79.  For 
   publisher information, see EJCBDN.  Volume(issue)/page/year: 17,73,1978 
  
TYPE OF TEST            : DNA inhibition 
TEST SYSTEM             : Rodent - rat Liver 
DOSE/DURATION           : 100 nmol/L 
REFERENCE : 
   TOXIA6 Toxicon.  (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, 
   UK)  V.1-    1962-  Volume(issue)/page/year: 25,1265,1987 
  
                            *** END OF RECORD *** 
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