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MSDS  : Phenothiazine, 10-(2-(1-methyl-2-piperidyl)ethyl)-2-(methylthio)-, monohydrochloride
CAS  : 130-61-0
SYNONYMS  : * Mellaril hydrochloride * Melleril (tablet) * 2-Methylmercapto-10-(2-(N-methyl-2-piperidyl)ethyl)phenothiazine hydrochloride * 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-methylthiophenothiazine hydrochloride * 10H-Phenothiazine, 10-(2-(1-methyl-2-piperidinyl)ethyl)-2-(methylthio)-, monohydrochloride * Thioridazine hydrochloride * USAF SZ-3 * USAF SZ-B
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : SP2275000
CHEMICAL NAME : Phenothiazine,
10-(2-(1-methyl-2-piperidyl)ethyl)-2-(methylthio)-,
monohydrochloride
CAS REGISTRY NUMBER : 130-61-0
LAST UPDATED : 199707
DATA ITEMS CITED : 14
MOLECULAR FORMULA : C21-H26-N2-S2.Cl-H
MOLECULAR WEIGHT : 407.07
WISWESSER LINE NOTATION : T C666 BN ISJ ES1 B2- BT6NTJ A1 &GH
COMPOUND DESCRIPTOR : Drug
Mutagen
Human
SYNONYMS/TRADE NAMES :
* Mellaril hydrochloride
* Melleril (tablet)
* 2-Methylmercapto-10-(2-(N-methyl-2-piperidyl)ethyl)phenothiazine
hydrochloride
* 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-methylthiophenothiazine
hydrochloride
* 10H-Phenothiazine, 10-(2-(1-methyl-2-piperidinyl)ethyl)-2-(methylthio)-,
monohydrochloride
* Thioridazine hydrochloride
* USAF SZ-3
* USAF SZ-B

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 864 mg/kg/18D-I
TOXIC EFFECTS :
Cardiac - pulse rate increase, without fall in BP
Endocrine - evidence of thyroid hyperfunction
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB
88, Oxford, UK) V.1- 1925- Volume(issue)/page/year: 60,445,1984

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1060 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,458,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 71 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,53,1972

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 360 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,53,1972

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 33 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
France) V.1- 1946- Volume(issue)/page/year: 14,793,1959

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 160 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,53,1972

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,53,1972

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 26 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,53,1972

** MUTATION DATA **

TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Unreported
TEST SYSTEM : Human
DOSE/DURATION : 80 mg/kg/4W (Intermittent)
REFERENCE :
HUGEDQ Human Genetics. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.31- 1976- Volume(issue)/page/year:
62,198,1982

TYPE OF TEST : Dominant lethal test
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 1200 mg/kg/30D
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
Volume(issue)/page/year: 11,403,1973

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84573
No. of Facilities: 83 (estimated)
No. of Industries: 1
No. of Occupations: 4
No. of Employees: 330 (estimated)

NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84573
No. of Facilities: 135 (estimated)
No. of Industries: 1
No. of Occupations: 3
No. of Employees: 4095 (estimated)
No. of Female Employees: 2136 (estimated)

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Positive: D melanogaster-reciprocal translocation


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Phenol, 2-nitro-3,4,6-trichloro-, cyclohexylcarbamate 14572-54-4
Phenothiazine,10-(N-(3-(4-methyl-1-piperazinyl)propyl)glycyl)-,trimaleate 14572-54-4
Phenothiazine,10-(3-(4-methyl-1-piperazinyl)propyl)-, maleate 6002-77-3
Phenothiazine,10-(3-(4-methyl-1-piperazinyl)propyl)-, malonate 22539-28-2
Phenothiazine,10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)- 117-89-5
Phenothiazine,10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-, dihydrochloride 440-17-5
Phenothiazine,10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-, maleate (1:2) 605-75-4
Phenothiazine,10-(N-methyl-N-(2-piperidinoethyl)glycyl)- 95128-63-5
Phenothiazine, 10-(1-methyl-3-piperidyl)- 101976-53-8
Phenothiazine, 10-(N-methyl-4-piperidyl)- 63834-14-0
Phenothiazine, 10-(2-(1-methyl-2-piperidyl)ethyl)- 32367-75-2
Phenol, 2-nitro-3,4,6-trichloro-,3,4-dichlorocarbanilate 73986-60-4
10H-Phenothiazine,10-(1-(1-methyl-2-piperidyl)ethyl)-2-(methylsulfinyl)- 31863-89-5
Phenothiazine,10-(2-(1-methyl-2-piperidyl)ethyl)-2-(methylsulfinyl)- 5588-33-0
Phenothiazine,10-(2-(1-methyl-2-piperidyl)ethyl)-2-methylsulfonyl-, 14759-06-9
Phenothiazine,10-((1-methyl-2-piperidyl)ethyl)-2-(methylthio)- 50-52-2
Phenothiazine,10-(2-(1-methyl-2-piperidyl)ethyl)-2-(methylthio)-,and 10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)phenothiazine 50-52-2
Phenothiazine,10-(2-(1-methyl-2-piperidyl)ethyl)-2-(methylthio)-,monohydrochloride 130-61-0
Phenothiazine,10-((1-methyl-2-piperidyl)ethyl)-2-(methylthio)-,mixed with norephedrine hydrochloride (2:1) 130-61-0
Phenothiazine, 1-(1-methyl-2-piperidyl)methyl-, 60706-52-7
Phenothiazine, 10-((1-methyl-3-piperidyl)methyl)- 60-89-9
Phenothiazine, 10-(1-methyl-4-piperidyl)methyl- 3772-71-2
Phenol, 2-nitro-3,4,6-trichloro-, phenylcarbamate 14572-56-6
Phenothiazine, 10-((1-methyl-3-piperidyl)methyl)-,monohydrochloride 2975-36-2
10H-Phenothiazine,10-(2-(2-methyl-1-pyrrolidinyl)ethyl)-, 1',5-dioxide 2975-36-2
10H-Phenothiazine,10-(2-(2-methyl-1-pyrrolidinyl)ethyl)-,monohydrochloride 2975-36-2
Phenothiazine, 10-((1-methyl-3-pyrrolidinyl)methyl)- 1982-37-2
Phenothiazine, 10-((1-methyl-3-pyrrolidinyl)methyl)-,monohydrochloride 1229-35-2
Phenothiazine,10-(N-(2-morpholinoethyl)-beta-alanyl)-, dimaleate 1229-35-2
Phenothiazine,10-(3-(beta-morpholinoethylamino)propyl)-2-trifluoromethyl-, dihydrochloride 3772-70-1
Phenothiazine, 10-(N-(2-morpholinoethyl)glycyl)-,dimaleate 102602-97-1
Phenothiazine, 10-(3-morpholinopropyl)- 4935-70-0
Phenothiazine,10-(N-(3-morpholinopropyl)-beta-alanyl)-, dimaleate 4935-70-0
Phenol, p-nitro-, zinc salt 64047-83-2
Phenothiazine, 10-(N-(3-morpholinopropyl)glycyl)-,dimaleate 107176-89-6
Phenothiazine, 10-(3-morpholinopropyl)-,monohydrochloride 107176-89-6
10H-Phenothiazine,10-(2-(4-morpholinyl)ethyl)-2-(trifluoromethyl)-,monohydrochloride 107176-89-6
10H-Phenothiazine, 10-((1-naphthalenyloxy)acetyl)- 136776-28-8
10H-Phenothiazine, 10-((2-naphthalenyloxy)acetyl)- 136801-31-5
Phenothiazine,10-(((o-nitrobenzylidene)hydrazono)acetyl)- 54012-79-2
10H-Phenothiazine, 10-((2-nitrophenoxy)acetyl)- 41648-56-0
10H-Phenothiazine, 10-((3-nitrophenoxy)acetyl)- 136776-23-3
10H-Phenothiazine, 10-((4-nitrophenoxy)acetyl)- 41648-57-1
10H-Phenothiazine,10-(((1-(4-nitrophenyl)ethylidene)hydrazino)acetyl)- 68026-83-5
Phenol, nonyl- 25154-52-3
10H-Phenothiazine, 3-nitro-10-phenyl-, 5-oxide 63185-29-5
Phenothiazine,10-(3-(octahydro-2H-pyrido(1,2-a)pyrazin-2-yl)propyl)-, maleate (1:2) 33492-19-2
Phenothiazine,10-(3-(octahydro-2H-pyrido(1,2-a)pyrazin-2-yl)propyl)-2-(trifluoromethyl)-, maleate (1:2) 33492-21-6
10H-Phenothiazine,10-((octahydro-2H-quinolizin-1-yl)acetyl)-,(1S-trans)- 104960-17-0
10H-Phenothiazine,10-((octahydro-2H-quinolizin-1-yl)acetyl)-2-(trifluoromethyl)-, (1S-trans)- 156213-25-1

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