| MSDS   | : | 3H-Phenothiazine, 7-amino-3-imino-, monohydrochloride
| | CAS   | : | 581-64-6 | | SYNONYMS   | : | * C.I. 52000
* Cyanine
* 3,7-Diaminophenazathionium chloride
* Katalysin
* Lauthsches violett
* Lauth's Violet
* Phenothiazin-5-ium, 3,7-diamino-, chloride
* Thionin
* Thionine
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*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : SN5425000
CHEMICAL NAME : 3H-Phenothiazine, 7-amino-3-imino-, monohydrochloride
CAS REGISTRY NUMBER : 581-64-6
LAST UPDATED : 199701
DATA ITEMS CITED : 10
MOLECULAR FORMULA : C12-H10-N3-S.Cl
MOLECULAR WEIGHT : 263.76
WISWESSER LINE NOTATION : T C666 BN ISJ FZ IG LZ
COMPOUND DESCRIPTOR : Mutagen
SYNONYMS/TRADE NAMES :
* C.I. 52000
* Cyanine
* 3,7-Diaminophenazathionium chloride
* Katalysin
* Lauthsches violett
* Lauth's Violet
* Phenothiazin-5-ium, 3,7-diamino-, chloride
* Thionin
* Thionine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 215 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 204,288,1947
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 7400 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory stimulation
Lungs, Thorax, or Respiration - other changes
REFERENCE :
SMBUA9 Stanford Medical Bulletin. (Palo Alto, CA) V.1-20, 1942-62.
Discontinued. Volume(issue)/page/year: 9,96,1951
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD691-490
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 8030 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory stimulation
Lungs, Thorax, or Respiration - other changes
REFERENCE :
SMBUA9 Stanford Medical Bulletin. (Palo Alto, CA) V.1-20, 1942-62.
Discontinued. Volume(issue)/page/year: 9,96,1951
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 1 mg/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 40,203,1976
TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Bacillus subtilis
DOSE/DURATION : 2 mg/disc
REFERENCE :
TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo
Metropolitan Research Laboratory of Public Health. (Tokyo-toritsu Eisei
Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1-
1949/50- Volume(issue)/page/year: 27,153,1976
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Inconclusive: S cerevisiae gene conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***
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| ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| | NAME | CAS |
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Phenol, 2,4,6-tris(dimethylaminomethyl)-
| 90-72-2 |
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Phenol, 2,4,6-tris(dimethylaminomethyl)-, trioleate
| 67274-16-2 |
|
Phenol, 2,4,6-tris(1,1-dimethylethyl)-
| 732-26-3 |
|
Phenol, p-vinyl-
| 2628-17-3 |
|
Phenomycin
| 12624-22-5 |
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Phenoxazin-5-ium,1,3-diamino-7-(diethylamino)-8-methyl-, chloride
| 10127-36-3 |
|
Phenol, o-(2-methyl-2-thiazolidinyl)-
| 16763-42-1 |
|
Phenoselenazine, 3-anilino-, monohydrochloride
| 16763-42-1 |
|
Phenoselenazine, 3-(1-naphthylamino)-
| 16763-42-1 |
|
Phenoselenazine, 3-(p-nitroanilino)-
| 16763-42-1 |
|
Phenoselenazine, 3-(o-toluidino)-
| 16763-42-1 |
|
Phenoselenazin-5-ium,3-amino-7-(dimethylamino)-2-methyl-, chloride
| 53184-19-3 |
|
Phenosmolin
| 63496-48-0 |
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10H-Phenotellurazine, 3,7-dibromo-10-ethyl-
| 98326-29-5 |
|
10H-Phenotellurazine, 3,7,10-trimethyl-, dichloride
| 98326-29-5 |
|
Phenothiaphosphine, 10-hydroxy-2,8-dimethyl-,10-oxide
| 31121-37-6 |
|
Phenothiazine
| 92-84-2 |
|
Phenol, p-(2-methyl-2-thiazolidinyl)-
| 16763-43-2 |
|
10H-Phenothiazine-2-acetic acid,7-hydroxy-alpha,10-dimethyl-
| 66146-56-3 |
|
10H-Phenothiazine-2-acetic acid,7-methoxy-alpha,10-dimethyl-, (+-)-
| 54323-85-2 |
|
Phenothiazine-2-acetic acid, 10-methyl-
| 13993-65-2 |
|
Phenothiazine, 10-acetyl-2-(2-amino-4-thiazolyl)-
| 13993-65-2 |
|
10H-Phenothiazine,2-acetyl-10-(((3-chloro-2-(2-chlorophenyl)-4-oxo-1-azetidinyl) amino)acetyl)-
| 89258-16-2 |
|
10H-Phenothiazine,2-acetyl-10-(((3-chloro-2-(3,4-dichlorophenyl)-4-oxo-1-azetidinyl)amino) acetyl)-
| 89258-20-8 |
|
10H-Phenothiazine,2-acetyl-10-(((3-chloro-2-(4-(dimethylamino)phenyl)-4-oxo-1-azetidinyl) amino)acetyl)-
| 89258-17-3 |
|
10H-Phenothiazine,2-acetyl-10-(((3-chloro-2-(4-hydroxyphenyl)-4-oxo-1-azetidinyl)amino) acetyl)-
| 89258-18-4 |
|
10H-Phenothiazine,2-acetyl-10-(((3-chloro-2-(4-methoxyphenyl)-4-oxo-1-azetidinyl)amino) acetyl)-
| 89258-19-5 |
|
10H-Phenothiazine,2-acetyl-10-(((2-(4-chlorophenyl)-1,1-dimethylethyl)amino)acetyl)-
| 89516-34-7 |
|
Phenol,2-(4-(2-((4-methyl-5-thiazolyl)oxy)ethyl)-1-piperazinyl)-, monohydrochloride
| 136996-53-7 |
|
10H-Phenothiazine,2-acetyl-10-(((2-(4-chlorophenyl)ethyl)amino)acetyl)-
| 89516-36-9 |
|
10H-Phenothiazine,2-acetyl-10-((((2-chlorophenyl)methylene)hydrazino)acetyl)-
| 89258-04-8 |
|
10H-Phenothiazine,2-acetyl-10-((((2,4-dichlorophenyl)methyl)amino)acetyl)-
| 89516-32-5 |
|
10H-Phenothiazine,2-acetyl-10-((((3,4-dichlorophenyl)methylene)hydrazino)acetyl)-
| 89258-08-2 |
|
10H-Phenothiazine,2-acetyl-10-((((4-(dimethylamino)phenyl)methylene)hydrazino)acetyl)-
| 89258-05-9 |
|
10H-Phenothiazine,2-acetyl-10-((((2,4-dimethylphenyl)methyl)amino)acetyl)-
| 89516-31-4 |
|
10H-Phenothiazine,2-acetyl-10-((((2-hydroxy-4-methoxyphenyl)methylene)hydrazino)acetyl)-
| 89258-09-3 |
|
10H-Phenothiazine,2-acetyl-10-((((4-hydroxyphenyl)methylene)hydrazino)acetyl)-
| 89258-06-0 |
|
10H-Phenothiazine,2-acetyl-10-((((4-hydroxyphenyl)methylene)hydrazino)acetyl)-
| 89258-07-1 |
|
Phenothiazine,2-acetyl-10-(3-(4-methoxypiperidino)propyl)-,hydrochloride
| 101952-94-7 |
|
Phenol, 2-(2-methyl-5-(2-thienyl)-1H-pyrrol-1-yl)-
| 91318-39-7 |
|
10H-Phenothiazine,2-acetyl-10-(((2-(4-methylphenyl)ethyl)amino)acetyl)-
| 89516-38-1 |
|
10H-Phenothiazine,2-acetyl-10-((((3-methylphenyl)methylene)hydrazino)acetyl)-
| 89258-11-7 |
|
10H-Phenothiazine,2-acetyl-10-((((4-nitrophenyl)methylene)hydrazino)acetyl)-
| 89258-10-6 |
|
10H-Phenothiazine,2-acetyl-10-((octahydro-2H-quinolizin-1-yl)acetyl)-,(1S-trans)-
| 156213-26-2 |
|
10H-Phenothiazine,2-acetyl-10-(((2-phenylethyl)amino)acetyl)-
| 89516-35-8 |
|
10H-Phenothiazine,2-acetyl-10-((((3-phenylmethoxy)phenyl)methylene)hydrazino)acetyl)-
| 89258-14-0 |
|
10H-Phenothiazine,2-acetyl-10-((((3,4,5-trimethoxyphenyl)methylene)hydrazino)acetyl)-
| 89258-15-1 |
|
Phenothiazine-3-acrylic acid, 10-methyl-,1,4-piperazinylenediethylene ester
| 89258-15-1 |
|
3H-Phenothiazine, 7-amino-3-imino-, monohydrochloride
| 581-64-6 |
|
10H-Phenothiazine,10-(2-(1-azaspiro(4.5)dec-1-yl)ethyl)-,monohydrochloride
| 581-64-6 |
|
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