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MSDS  : Phosphoramidothioic acid, O,S-dimethyl ester
CAS  : 10265-92-6
SYNONYMS  : * Acephate-met * BAY 71628 * Bayer 71628 * Chevron 9006 * Chevron ortho 9006 * O,S-Dimethyl ester amide of amidothioate * O,S-Dimethyl phosphoramidothioate * ENT 27,396 * Hamidop * Metamidofos estrella * Methamidophos * Monitor * NSC 190987 * Ortho 9006 * Pillaron * SRA 5172 * Tahmabon * Tamaron * Thiophosphorsaeure-O,S-dimethylesteramid
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : TB4970000
CHEMICAL NAME : Phosphoramidothioic acid, O,S-dimethyl ester
CAS REGISTRY NUMBER : 10265-92-6
BEILSTEIN REFERENCE NO. : 1098870
LAST UPDATED : 199710
DATA ITEMS CITED : 31
MOLECULAR FORMULA : C2-H8-N-O2-P-S
MOLECULAR WEIGHT : 141.14
WISWESSER LINE NOTATION : 1SPZS&O1
COMPOUND DESCRIPTOR : Agricultural Chemical
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Acephate-met
* BAY 71628
* Bayer 71628
* Chevron 9006
* Chevron ortho 9006
* O,S-Dimethyl ester amide of amidothioate
* O,S-Dimethyl phosphoramidothioate
* ENT 27,396
* Hamidop
* Metamidofos estrella
* Methamidophos
* Monitor
* NSC 190987
* Ortho 9006
* Pillaron
* SRA 5172
* Tahmabon
* Tamaron
* Thiophosphorsaeure-O,S-dimethylesteramid

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 257 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - fasciculations
Sense Organs and Special Senses (Eye) - miosis (pupillary constriction)
Skin and Appendages - sweating
REFERENCE :
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10
Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year:
306,125,1982

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 360 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - fasciculations
Sense Organs and Special Senses (Eye) - miosis (pupillary constriction)
Skin and Appendages - sweating
REFERENCE :
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10
Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year:
306,125,1982

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 600 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Autonomic Nervous System - parasympatholytic
Behavioral - coma
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 14,390,1994

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 7500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARSIM* Agricultural Research Service, USDA Information Memorandum.
(Beltsville, MD 20705) Volume(issue)/page/year: 20,7,1966

TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 162 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd,
eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year:
A265,1984

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College
Science Pub., 1969 Volume(issue)/page/year: 5,149,1976

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 15 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - convulsions or effect on seizure threshold
Skin and Appendages - hair
REFERENCE :
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1971- Volume(issue)/page/year:
13,267,1980

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - tremor
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1971- Volume(issue)/page/year:
18,28,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 14 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1971- Volume(issue)/page/year:
7,83,1977

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 5300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1971- Volume(issue)/page/year:
7,83,1977

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 27 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.1- 1953- Volume(issue)/page/year: 18,189,1970

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College
Science Pub., 1969 Volume(issue)/page/year: 5,149,1976

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 118 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada,
171 Slater St., Ottawa, Ont., Canada) Volume(issue)/page/year: 6,333,1973

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College
Science Pub., 1969 Volume(issue)/page/year: 5,149,1976

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JEENAI Journal of Economic Entomology. (Entomological Soc. of America, 4603
Calvert Rd., College Park, MD 20740) V.1- 1908- Volume(issue)/page/year:
62,934,1969

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : 25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College
Science Pub., 1969 Volume(issue)/page/year: 5,149,1976

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - quail
DOSE/DURATION : 57500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport
Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year:
9,563,1991

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - domestic
DOSE/DURATION : 8 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
070944) V.1- 1973- Volume(issue)/page/year: 10,185,1981

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 71890 ug/kg/13W-C
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Blood - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
35,101,1997

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 10 mg/kg
SEX/DURATION : female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
VEMJA8 Veterinary Medical Journal. (Cairo Univ., Faculty of Veterinary
Medicine, Giza, Egypt) V.1- 1953- Volume(issue)/page/year: 34,357,1986

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 4 mg/kg
SEX/DURATION : male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
ZYYZEW Zhongguo Yaolixue Yu Dulixue Zazhi. (Chinese Pharmacological
Society, 27 Tai-Ping Road, Beijing 100850, China) V.1- 1986-
Volume(issue)/page/year: 2,142,1988

** MUTATION DATA **

TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 6 mg/kg
REFERENCE :
ZNCBDA Zeitschrift fuer Naturforschung, Section C: Biosciences. (Verlag der
Zeitschrift fuer Naturforschung, Postfach 2645, D-7400 Tuebingen, Fed. Rep.
Ger.) V.29- 1974- Volume(issue)/page/year: 42,21,1987

TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 84 mg/kg/1W (Continuous)
REFERENCE :
ZNCBDA Zeitschrift fuer Naturforschung, Section C: Biosciences. (Verlag der
Zeitschrift fuer Naturforschung, Postfach 2645, D-7400 Tuebingen, Fed. Rep.
Ger.) V.29- 1974- Volume(issue)/page/year: 42,21,1987

TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Administration onto the skin
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 96 mg/kg/2W (Intermittent)
REFERENCE :
ZNCBDA Zeitschrift fuer Naturforschung, Section C: Biosciences. (Verlag der
Zeitschrift fuer Naturforschung, Postfach 2645, D-7400 Tuebingen, Fed. Rep.
Ger.) V.29- 1974- Volume(issue)/page/year: 42,21,1987

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION : 2 mg/L
REFERENCE :
ZNCBDA Zeitschrift fuer Naturforschung, Section C: Biosciences. (Verlag der
Zeitschrift fuer Naturforschung, Postfach 2645, D-7400 Tuebingen, Fed. Rep.
Ger.) V.29- 1974- Volume(issue)/page/year: 42,21,1987

TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 6 mg/kg
REFERENCE :
ZNCBDA Zeitschrift fuer Naturforschung, Section C: Biosciences. (Verlag der
Zeitschrift fuer Naturforschung, Postfach 2645, D-7400 Tuebingen, Fed. Rep.
Ger.) V.29- 1974- Volume(issue)/page/year: 42,21,1987

TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION : 250 ug/L
REFERENCE :
ZNCBDA Zeitschrift fuer Naturforschung, Section C: Biosciences. (Verlag der
Zeitschrift fuer Naturforschung, Postfach 2645, D-7400 Tuebingen, Fed. Rep.
Ger.) V.29- 1974- Volume(issue)/page/year: 42,21,1987

*** U.S. STANDARDS AND REGULATIONS ***

EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989

*** STATUS IN U.S. ***

On EPA IRIS database

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Phosphoramidothioic acid, N-acetyl-, O,S-dimethylester 30560-19-1
Phosphoramidothioic acid, acetyl-, O-ethyl S-methylester 30560-37-3
Phosphoramidothioic acid, acetylmethyl-, O,S-dimethylester 54473-31-3
Phosphoramidothioic acid, N-amidino-, O,O-diethylester 10539-37-4
Phosphonothioic acid, ethyl-, O,S-dimethyl ester,(R)-(+)- 10539-37-4
Phosphoramidothioic acid, O,O-bis(p-chlorophenyl)ester 15045-55-3
Phosphoramidothioic acid,O-(4-tert-butyl-2-chlorophenyl) O-methyl ester 5902-52-3
Phosphoramidothioic acid, N-(sec-butyl)-, O-ethylO-(6-nitro-m-tolyl) ester 36335-67-8
Phosphoramidothioic acid, butyryl-, O,S-dimethylester 30560-26-0
Phosphoramidothioic acid, (4-chlorobutyryl)-,O,S-dimethyl ester 54473-41-5
Phosphoramidothioic acid, cyclohexyl-, disodium salt 84439-60-1
Phosphoramidothioic acid, decanoyl-, O,S-dimethylester 30560-22-6
Phosphoramidothioic acid, dichloroacetyl-,O,S-dimethyl ester 30560-33-9
Phosphoramidothioic acid, N,N-diethyl-, O-methylester, S-ester with diethyl 2- mercaptoethylphosphoramidate 67293-72-5
Phosphoramidothioic acid, O,S-dimethyl ester 10265-92-6
Phosphonothioic acid, ethyl-, O,S-dimethyl ester,(S)-(-)- 10265-92-6
Phosphoramidothioic acid, dimethyl-, O-ethyl ester,O-ester with N,N-dimethyl-p-hydroxybenzenesulfonamide 2080-96-8
Phosphoramidothioic acid,(2-(dipropylamino)-2-oxoethyl)ethyl-, diethyl ester 105084-66-0
Phosphoramidothioic acid, dodecanoyl-, O,S-dimethylester 54473-33-5
Phosphoramidothioic acid, ethyl-,O-(4-t-butyl-2-chlorophenyl) O-methyl ester 7780-33-8
Phosphoramidothioic acid, ethyl-,O-(2-chloro-4-(methylthio)phenyl) O-methyl ester 54381-26-9
Phosphoramidothioic acid,(ethyl(2-hydroxyethyl)-thiocarbamoyl)-, O,O-dimethylester 63815-58-7
Phosphoramidothioic acid, O-ethyl S-methyl ester 10265-93-7
Phosphoramidothioic acid,(3-ethyl-5-methyl-2-oxazolidinylidene)-, O,S-dimethylester 22791-12-4
Phosphoramidothioic acid,(3-ethyl-5-methyl-4-oxo-2-oxazolidinylidene)-,O,S-dimethyl ester 39196-79-7
Phosphoramidothioic acid, ethyl-, O-methylO-(2,4,5-trichlorophenyl) ester 2591-74-4
Phosphonothioic acid, ethyl-, O,S-dipropyl ester 90220-15-8
Phosphoramidothioic acid, formyl-, O,S-dimethyl ester 54473-30-2
Phosphoramidothioic acid, hexanoyl-, O,S-dimethylester 30560-29-3
Phosphoramidothioic acid, (2-hydroxyethyl)-,O,O-diethyl ester 60566-87-2
Phosphoramidothioic acid,((2-hydroxyethyl)methylthiocarbamoyl)-, O,O-dimethylester 17702-63-5
Phosphoramidothioic acid, isobutyryl-, O,S-dimethylester 30560-28-2
Phosphoramidothioic acid, isopropyl-,O-(2,4-dichlorophenyl) O-methyl ester 299-85-4
Phosphoramidothioic acid, isopropyl-, O-ethylS-(2-(methoxymethylamino)-2-oxoethyl) ester 51893-82-4
Phosphoramidothioic acid, isopropyl-, O-ethylO-(2-nitro-p-tolyl) ester 33857-23-7
Phosphoramidothioic acid, N-isopropyl-, O-methylO-(2-nitro-p-tolyl) ester 36001-88-4
Phosphoramidothioic acid, N-isopropyl-,O-(2,4,5-trichlorophenyl)ester 35944-83-3
Phosphonothioic acid, ethyl-, O-ethyl ester 7776-66-1
Phosphoramidothioic acid, (methoxyacetyl)-,O,S-dimethyl ester 54473-43-7
Phosphoramidothioic acid, (1-methylethyl)-,O-(1,6-dihydro-5-methoxy-1-methyl-6-oxo-4-pyridazinyl) O-ethyl ester 60244-82-8
Phosphoramidothioic acid, (1-methylethyl)-,O-(1,6-dihydro-5-methoxy-1-methyl-6-oxo-4-pyridazinyl) O-methyl ester 37840-61-2
Phosphoramidothioic acid, methyl-, O-ethylO-(4-(methylthio)-m-tolyl) ester 3568-56-7
Phosphoramidothioic acid, N-methyl-, O-isopropylester 35944-84-4
Phosphoramidothioic acid, O-methylO-(2,4,5-trichlorophenyl) ester 2591-66-4
Phosphoramidothioic acid, octadecanoyl-, O,S-dimethylester 54473-52-8
Phosphoramidothioic acid, phenyl-, O,O-diethyl ester 3694-54-0
Phosphoramidothioic acid, propionyl-, O,S-dimethylester 30560-27-1
Phosphoramidothioic acid, propionyl-, O-methylS-2-propenyl ester 54473-55-1
Phosphonothioic acid, ethyl-, O-ethyl ester,anhydride with O,O-diethylphosphorothioate 63815-52-1
Phosphoramidothioic acid, propionyl-, O-methylS-2-propynyl ester 54473-56-2

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