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MSDS  : Phosphoric acid, dimethyl ester, ester with (E)-3-hydroxy-N-methylcrotonamide
CAS  : 6923-22-4
SYNONYMS  : * Apadrin * Azodrin * Azodrin-71 * Azodrin insecticide * Bilobran * Biloborn * C 1414 * Crisodrin * Ciba 1414 * Corophos * Crisodin * Crotonamide, 3-hydroxy-N-methyl-, dimethylphosphate, (E)- * 3-(Dimethoxyphosphinyloxy)N-methyl-cis-crotonamide * (E)-Dimethyl 1-methyl-3-(methylamino)-3-oxo-1-propenyl phosphate * O,O-Dimethyl-O-(2-N-methylcarbamoyl-1-methyl-vinyl)-fosfaat * O,O-Dimethyl-O-(2-N-methylcarbamoyl-1-methyl)-vinyl-phosphat * O,O-Dimethyl-O-(2-N-methylcarbamoyl-1-methyl-vinyl) phosphate * O,O-Dimethyl-O-(1-methyl-2-N-methyl-carbamoyl)-vinyl-phosphat * Dimethyl 1-methyl-2-(methylcarbamoyl)vinyl phosphate, cis * Dimethyl phosphate ester with (E)-3-hydroxy-N-methylcrotonamide * Dimethyl phosphate ester of 3-hydroxy-N-methyl-cis-crotonamide * Dimethyl phosphate of 3-hydroxy-N-methyl-cis-crotonamine * O,O-Dimetil-O-(2-N-metilcarbamoil-1-metil-vinil)-fosfato * E-Monocrotophos * ENT 27,129 * Glore phos 36 * Hazodrin * 3-Hydroxy-N-methylcrotonamide dimethyl phosphate * 3-Hydroxy-N-methyl-cis-crotonamide dimethyl phosphate * Monokrotofosz * cis-1-Methyl-2-methyl carbamoyl vinyl phosphate * Monocil * Monocil 40 * Monocron * Monocrotophos * Monodrin * Nuvacron * Nuvacron 20 * OMS 834 * Phosphate de dimethyle et de 2-methylcarbamoyl 1-methyl vinyle * Phosphoric acid, dimethyl ester, ester with cis-3-hydroxy-N-methylcrotonamide * Phosphoric acid, dimethyl 1-methyl-3-(methylamino)-3-oxo-1-propenyl ester, (E)- * Plantdrin * Pillardrin * SD 9129 * Shell SD 9129 * Susvin * Ulvair
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : TC4375000
CHEMICAL NAME : Phosphoric acid, dimethyl ester, ester with
(E)-3-hydroxy-N-methylcrotonamide
CAS REGISTRY NUMBER : 6923-22-4
BEILSTEIN REFERENCE NO. : 2331934
LAST UPDATED : 199712
DATA ITEMS CITED : 67
MOLECULAR FORMULA : C7-H14-N-O5-P
MOLECULAR WEIGHT : 223.19
WISWESSER LINE NOTATION : 1OPO&O1&OY1&U1VM1
COMPOUND DESCRIPTOR : Agricultural Chemical
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Apadrin
* Azodrin
* Azodrin-71
* Azodrin insecticide
* Bilobran
* Biloborn
* C 1414
* Crisodrin
* Ciba 1414
* Corophos
* Crisodin
* Crotonamide, 3-hydroxy-N-methyl-, dimethylphosphate, (E)-
* 3-(Dimethoxyphosphinyloxy)N-methyl-cis-crotonamide
* (E)-Dimethyl 1-methyl-3-(methylamino)-3-oxo-1-propenyl phosphate
* O,O-Dimethyl-O-(2-N-methylcarbamoyl-1-methyl-vinyl)-fosfaat
* O,O-Dimethyl-O-(2-N-methylcarbamoyl-1-methyl)-vinyl-phosphat
* O,O-Dimethyl-O-(2-N-methylcarbamoyl-1-methyl-vinyl) phosphate
* O,O-Dimethyl-O-(1-methyl-2-N-methyl-carbamoyl)-vinyl-phosphat
* Dimethyl 1-methyl-2-(methylcarbamoyl)vinyl phosphate, cis
* Dimethyl phosphate ester with (E)-3-hydroxy-N-methylcrotonamide
* Dimethyl phosphate ester of 3-hydroxy-N-methyl-cis-crotonamide
* Dimethyl phosphate of 3-hydroxy-N-methyl-cis-crotonamine
* O,O-Dimetil-O-(2-N-metilcarbamoil-1-metil-vinil)-fosfato
* E-Monocrotophos
* ENT 27,129
* Glore phos 36
* Hazodrin
* 3-Hydroxy-N-methylcrotonamide dimethyl phosphate
* 3-Hydroxy-N-methyl-cis-crotonamide dimethyl phosphate
* Monokrotofosz
* cis-1-Methyl-2-methyl carbamoyl vinyl phosphate
* Monocil
* Monocil 40
* Monocron
* Monocrotophos
* Monodrin
* Nuvacron
* Nuvacron 20
* OMS 834
* Phosphate de dimethyle et de 2-methylcarbamoyl 1-methyl vinyle
* Phosphoric acid, dimethyl ester, ester with
cis-3-hydroxy-N-methylcrotonamide
* Phosphoric acid, dimethyl 1-methyl-3-(methylamino)-3-oxo-1-propenyl
ester, (E)-
* Plantdrin
* Pillardrin
* SD 9129
* Shell SD 9129
* Susvin
* Ulvair

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 8 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave.,
Willoughy, OH 44094) Volume(issue)/page/year: -,C209,1991

TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 63 mg/m3/4H
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - muscle contraction or spasticity
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
EGESAQ Egeszsegtudomany. (Kultura, POB 149, H-1389 Budapest, Hungary) V.1-
1957- Volume(issue)/page/year: 24,173,1980

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 112 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71.
Discontinued. Volume(issue)/page/year: 9,119,1970

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 20 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
07094) V.1- 1966- Volume(issue)/page/year: 19,47,1978

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 6964 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- Volume(issue)/page/year:
40,124,1970

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 9200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB277-077

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 15 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARSIM* Agricultural Research Service, USDA Information Memorandum.
(Beltsville, MD 20705) Volume(issue)/page/year: 20,21,1966

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 3800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
13,37,1968

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 8710 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great
Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
Volume(issue)/page/year: 19,612,1967

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 9200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great
Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
Volume(issue)/page/year: 19,612,1967

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 270 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
REFERENCE :
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas
Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)-
Volume(issue)/page/year: 18,102,1986

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - pigeon
DOSE/DURATION : 3 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
20,57,1971

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : 3540 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
11,49,1967

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - quail
DOSE/DURATION : 4 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
20,57,1971

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - duck
DOSE/DURATION : 3360 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
22,556,1972

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Bird - duck
DOSE/DURATION : 30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
47,451,1979

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - wild bird species
DOSE/DURATION : 800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JTCEEM Journal de Toxicologie Clinique et Experimentale. (SPPIF, B.P.22,
F-41353 Vineuil, France) V.5- 1985- Volume(issue)/page/year:
6(3),175,1986

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Bird - wild bird species
DOSE/DURATION : 4200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
26,154,1973

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 34500 ug/kg/30D-I
TOXIC EFFECTS :
Autonomic Nervous System - sympathomimetic
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - monoamine oxidase
REFERENCE :
RPZHAW Roczniki Panstwowego Zakladu Higieny. (Ars Polona, POB 1001, 00-068
Warsaw 1, Poland) V.1- 1950- Volume(issue)/page/year: 31,605,1980

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 99 mg/kg/16D-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
Biochemical - Metabolism (Intermediary) - other proteins
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
07094) V.1- 1966- Volume(issue)/page/year: 49,723,1992

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 27 mg/kg/90D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in spleen weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
07094) V.1- 1966- Volume(issue)/page/year: 44,230,1990

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : 184 mg/kg/3W-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
11,49,1967

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - cattle
DOSE/DURATION : 14 mg/kg/28D-I
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
Related to Chronic Data - death
REFERENCE :
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International
Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
Volume(issue)/page/year: 62,290,1988

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 16800 ug/kg
SEX/DURATION : female 14 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas
Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)-
Volume(issue)/page/year: 26,126,1994

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 500 ug/plate
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB84-138973

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 5 mg/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 28,405,1975

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 2 pph
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB84-138973

TYPE OF TEST : Gene conversion and mitotic recombination
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 5 pph
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB268-647

TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Human Fibroblast
DOSE/DURATION : 1 mmol/L
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB268-647

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Leukocyte
DOSE/DURATION : 10 nmol/L
REFERENCE :
IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical
Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913-
Volume(issue)/page/year: 76,912,1982

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 50 ug/L
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
07094) V.1- 1966- Volume(issue)/page/year: 41,737,1988

TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 12500 ng/L
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
07094) V.1- 1966- Volume(issue)/page/year: 41,737,1988

TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - rat Cells - not otherwise specified
DOSE/DURATION : 25 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 188,311,1987

TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 1500 ug/kg
REFERENCE :
IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical
Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913-
Volume(issue)/page/year: 76,912,1982

TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 1500 ug/kg
REFERENCE :
IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical
Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913-
Volume(issue)/page/year: 76,912,1982

TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Subcutaneous
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 5 mg/kg
REFERENCE :
CYTOAN Cytologia. (Japan Pub. Trading Co. (USA), 1255 Howard St., San
Francisco, CA 94103) V.1- 1929- Volume(issue)/page/year: 53,801,1988

TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 5 mg/kg
REFERENCE :
CYTOAN Cytologia. (Japan Pub. Trading Co. (USA), 1255 Howard St., San
Francisco, CA 94103) V.1- 1929- Volume(issue)/page/year: 53,801,1988

TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 750 mg/L
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB84-138973

TYPE OF TEST : Sperm Morphology
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 1800 ug/kg/5D (Intermittent)
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
07094) V.1- 1966- Volume(issue)/page/year: 41,189,1988

TYPE OF TEST : Sperm Morphology
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 12500 ug/kg
REFERENCE :
CYTOAN Cytologia. (Japan Pub. Trading Co. (USA), 1255 Howard St., San
Francisco, CA 94103) V.1- 1929- Volume(issue)/page/year: 53,801,1988

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 200 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 188,241,1987

TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 100 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 188,311,1987

TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Bird - chicken
DOSE/DURATION : 1250 ug/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 292,231,1993

TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Bird - chicken
DOSE/DURATION : 5 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 292,231,1993

TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Bird - chicken
DOSE/DURATION : 5 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 292,231,1993

*** REVIEWS ***

ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997

ACGIH TLV-TWA 0.25 mg/m3 (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997

TOXICOLOGY REVIEW
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year:
46,1,1973

TOXICOLOGY REVIEW
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year:
63,1,1976

*** U.S. STANDARDS AND REGULATIONS ***

EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989

*** OCCUPATIONAL EXPOSURE LIMITS ***

OEL-AUSTRALIA:TWA 0.25 mg/m3 JAN 1993

OEL-BELGIUM:TWA 0.25 mg/m3 JAN 1993

OEL-DENMARK:TWA 0.25 mg/m3 JAN 1993

OEL-FRANCE:TWA 0.25 mg/m3 JAN 1993

OEL-THE NETHERLANDS:TWA 0.25 mg/m3 JAN 1993

OEL-SWITZERLAND:TWA 0.25 mg/m3 JAN 1993

OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV

OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO MONOCROTOPHOS-air:10H TWA 0.25 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Positive: In vitro UDS-human fibroblast; S
cerevisiae-homozygosis

EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal; TRP
reversion

EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA
without S9

EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test

EPA TSCA Section 8(d) unpublished health/safety studies

On EPA IRIS database

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600


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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Phosphoric acid, diisobutyl 1,2,2,2-tetrachloroethylester 102305-57-7
Phosphoric acid, diisobutyl 2,2,2-trichloroethylester 36366-20-8
Phosphoric acid, diisobutyl 5,5,5-trichloropentylester 36266-98-5
Phosphoric acid, diisopropyl p-nitrophenyl ester 3254-66-8
Phosphoric acid, diisopropyl 2-piperidinoethyl ester 17875-13-7
Phosphoric acid, diisopropyl(1-piperidino-2-propyl)ester 15870-42-5
Phosphoric acid, O,O-diisopropyl O-(3-pyridyl) ester 78218-73-2
Phosphoric acid, diisopropyl 1,2,2,2-tetrabromoethylester 102305-58-8
Phosphoric acid, diisopropyl 1,2,2,2-tetrachloroethylester 3943-55-3
Phosphonothioic acid, methyl-,O-(4-bromo-2,5-dichlorophenyl) O-propyl ester 6173-20-2
Phosphoric acid, diisopropyl 5,5,5-trichloropentylester 36357-81-0
Phosphoric acid,(3-(dimethylamino)-1-hydroxypropylidene)bis-,disodium salt 121368-58-9
Phosphoric acid, 3-(dimethylamino)propyl2-(1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxopurin-7-yl)ethyl ester 69387-77-5
Phosphoric acid, dimethyl 2-chloro-4-nitrophenylester 17650-76-9
Phosphoric acid, dimethyl 3,5-dimethyl-4-nitrophenylester 50590-06-2
Phosphoric acid, dimethyl 2,5-dimethyl-4-nitrophenylester 50590-04-0
Phosphoric acid, dimethyl ester 813-78-5
Phosphoric acid, dimethyl ester, ester with2-chloro-N,N-diethyl-4-hydroxybenzenesulfonamide 3383-27-5
Phosphoric acid, dimethyl ester, ester with2-chloro-N,N-diethyl-3-hydroxycrotonamide 13171-21-6
Phosphoric acid, dimethyl ester, ester with2-chloro-N-ethyl-3-hydroxycrotonamide 13171-22-7
Phosphonothioic acid, methyl-, S-butyl O-ethyl ester,(-)- 65167-56-8
Phosphoric acid, dimethyl ester, ester with2-chloro-3-hydroxycrotonamide 16655-69-9
Phosphoric acid, dimethyl ester, ester with2-chloro-3-hydroxycrotonamide, (Z)- 16655-69-9
Phosphoric acid, dimethyl ester, ester with2-chloro-4-hydroxy-N,N-dimethylbenzenesulfonamide 3383-22-0
Phosphoric acid, dimethyl ester, ester with2-chloro-N-methyl-3-hydroxycrotonamide 34491-04-8
Phosphoric acid, dimethyl ester, ester withN,N-diethyl-p-hydroxybenzenesulfonamide 3079-00-3
Phosphoric acid, dimethyl ester, ester withp-hydroxybenzenesulfonamide 115-92-4
Phosphoric acid, dimethyl ester, ester with3-hydroxycrotonamide, (Z)- 17705-63-4
Phosphoric acid, dimethyl ester, ester withp-hydroxy-N,N-dimethylbenzenesulfonamide 960-25-8
Phosphoric acid, dimethyl ester, ester withp-hydroxybenzonitrile 61090-94-6
Phosphoric acid, dimethyl ester, ester with3-hydroxycrotonamide 14510-15-7
Phosphonothioic acid, methyl-, S-butyl O-ethyl ester,(+)- 65167-55-7
Phosphoric acid, dimethyl ester, ester with(E)-3-hydroxy-N,N-dimethylcrotonamide 141-66-2
Phosphoric acid, dimethyl ester, 3-ester with3-hydroxy-N-(hydroxymethyl)crotonamide, (E)- 2673-67-8
Phosphoric acid, dimethyl ester, 3-ester with3-hydroxy-N-(hydroxymethyl)-N-methylcrotonamide,(E)- 2673-65-6
Phosphoric acid, dimethyl ester, ester with(E)-3-hydroxy-N-methoxy-N-methylcrotonamide 25601-84-7
Phosphoric acid, dimethyl ester, ester with(E)-3-hydroxy-N-methylcrotonamide 6923-22-4
Phosphoric acid, dimethyl ester, ester with2-(1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxopurin-7-yl)ethyl ester 69387-72-0
Phosphoric acid, dimethyl ethyl ester 10463-05-5
Phosphoric acid, dimethyl 3-ethyl-4-nitrophenyl ester 69689-40-3
Phosphoric acid, dimethyl 2-fluoro-4-nitrophenylester 50589-97-4
Phosphoric acid, dimethyl 3-fluoro-4-nitrophenylester 50589-91-8
Phosphonothioic acid, methyl-, S-butyl O-ethyl ester,(+-)- 65143-01-3
Phosphoric acid, dimethyl 4-formamido-m-tolyl ester 65143-01-3
Phosphoric acid, (O,O-dimethyl)O-(3-formyl-4-nitrophenyl) ester 59417-74-2
Phosphoric acid, dimethyl3-(hydroxymethyl)-4-nitrophenyl ester 66558-68-7
Phosphoric acid, dimethyl 3-iodo-4-nitrophenyl ester 50589-95-2
Phosphoric acid, dimethyl 3-isopropyl-4-nitrophenylester 13074-11-8
Phosphoric acid, dimethyl 5-methyl-3-isoxazolyl ester 32306-31-3
Phosphoric acid, dimethyl 4-(methylsulfinyl)-m-tolylester 6552-13-2

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