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MSDS  : Phosphorothioic acid, O-(2-(diethylamino)-6-methyl-4-pyrimidinyl) O,O-dimethyl ester
CAS  : 29232-93-7
SYNONYMS  : * Actelic * Actellic * Actellifog * Aktelik * Aktellik * BLEX * 2-Diethylamino-6-methylpyrimidin-4-yl dimethyl phosphorothionate * O-(2-(Diethylamino)-6-methyl-4-pyrimidinyl)O,O-dimethyl phosphorothioate * O-(2-Diethylamino-6-methylpyrimidin-4-yl) O,O-dimethyl phosphorothioate * ENT 27699GC * Fosforan pirimidyny * Methylpirimiphos * OMS 1424 * Pirimifosmethyl * Pirimiphos-methyl * Plant protection PP511 * PP511 * Pyridimine phosphate * Pyrimiphos methyl * Silosan * Sybol 2
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : TF1410000
CHEMICAL NAME : Phosphorothioic acid,
O-(2-(diethylamino)-6-methyl-4-pyrimidinyl)
O,O-dimethyl ester
CAS REGISTRY NUMBER : 29232-93-7
BEILSTEIN REFERENCE NO. : 0755726
LAST UPDATED : 199710
DATA ITEMS CITED : 22
MOLECULAR FORMULA : C11-H20-N3-O3-P-S
MOLECULAR WEIGHT : 305.37
WISWESSER LINE NOTATION : T6N CNJ BN2&2 DOPS&O1&O1 F1
COMPOUND DESCRIPTOR : Agricultural Chemical
Mutagen
SYNONYMS/TRADE NAMES :
* Actelic
* Actellic
* Actellifog
* Aktelik
* Aktellik
* BLEX
* 2-Diethylamino-6-methylpyrimidin-4-yl dimethyl phosphorothionate
* O-(2-(Diethylamino)-6-methyl-4-pyrimidinyl)O,O-dimethyl phosphorothioate
* O-(2-Diethylamino-6-methylpyrimidin-4-yl) O,O-dimethyl phosphorothioate
* ENT 27699GC
* Fosforan pirimidyny
* Methylpirimiphos
* OMS 1424
* Pirimifosmethyl
* Pirimiphos-methyl
* Plant protection PP511
* PP511
* Pyridimine phosphate
* Pyrimiphos methyl
* Silosan
* Sybol 2

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1250 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - ataxia
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
SSCMBX Scripta Scientifica Medica. (Durzhavno Izdatelstvo Meditsina i
Fizkultura, P1. Slaveikov II, Sofia, Bulgaria) V.4(2)- 1965-
Volume(issue)/page/year: 20,33,1983

TYPE OF TEST : LC - Lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >150 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 48(6),32,1983

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >4592 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave.,
Willoughy, OH 44094) Volume(issue)/page/year: -,C7,1991

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College
Science Pub., 1969 Volume(issue)/page/year: 5,184,1976

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English
translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1- 1967- Volume(issue)/page/year: 16(1),45,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College
Science Pub., 1969 Volume(issue)/page/year: 5,184,1976

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport
Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year:
9,694,1991

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College
Science Pub., 1969 Volume(issue)/page/year: 5,184,1976

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : 30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport
Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year:
9,694,1991

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - quail
DOSE/DURATION : 140 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport
Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year:
9,694,1991

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HPBIA9 Herba Polonica. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland)
V.11- 1965- Volume(issue)/page/year: 21,53,1975

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10736 mg/kg/9W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Blood - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 48(6),32,1983

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1 gm/kg/4W-I
TOXIC EFFECTS :
Blood - change in clotting factors
Blood - changes in erythrocyte (RBC) count
Blood - changes in leukocyte (WBC) count
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
Volume(issue)/page/year: 25,190,1987

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 601 mg/kg/26W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - proteinuria
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 48(6),32,1983

TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 24 mg/m3/4H/17W-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 50(5),90,1985

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 5 mg/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 28,405,1975

TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Unreported
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 500 mg/kg
REFERENCE :
TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English
translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1- 1967- Volume(issue)/page/year: 16(1),45,1982

TYPE OF TEST : Sperm Morphology
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 400 mg/kg/5D (Continuous)
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
07094) V.1- 1966- Volume(issue)/page/year: 36,680,1986

*** REVIEWS ***

TOXICOLOGY REVIEW
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year:
63,1,1976

*** U.S. STANDARDS AND REGULATIONS ***

EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989

*** STATUS IN U.S. ***

On EPA IRIS database

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Phosphorothioic acid, S-2,6-diaminohexyl ester,dihydrate, (L)- 78219-01-9
Phosphorothioic acid, S-2,3-diaminopropyl ester 78219-00-8
Phosphorothioic acid, S-(1,2-dibutoxycarbonyl)ethylO,O-dimethyl ester 3700-98-9
Phosphorothioic acid, S-(2-(dibutylamino)-2-oxoethyl)O,O-diethyl ester 35841-68-0
Phosphorothioic acid, dibutyl ester, potassium salt 33908-73-5
Phosphorothioic acid, O,O-dibutylS-((4-hydroxy-3-methyl-2,6-diphenyl-4-piperidinyl)ethynyl) ester, (2-alpha,3-beta,4-alpha,6-alpha)- 72973-03-6
Phosphorothioic acid, O,O-dibutylS-((4-hydroxy-3-methyl-2,6-diphenyl-4-piperidinyl)ethynyl) ester, (2-alpha,3-beta,4-beta,6-alpha)- 72973-06-9
Phosphorothioic acid, O,O-dibutylS-(2-(methylamino)-2-oxoethyl) ester 35841-71-5
Phosphorodithioic acid, O,O-diisopropyl ester,S-ester with 6-chloro-2-(mercaptomethyl)-5-methyl-3(2H)-pyridazinone 51356-22-0
Phosphorothioic acid, O-(2,5-dichloro-4-iodophenyl)O,O-diethyl ester 7533-79-1
Phosphorothioic acid, O-(2,5-dichloro-4-iodophenyl)O,O-dimethyl ester 18181-70-9
Phosphorothioic acid, O-(dichloro(methylthio)phenyl)O,O-diethyl ester 60238-56-4
Phosphorothioic acid, O-(2,4-dichloro-5-nitrophenyl)O,O-diethyl ester 84197-36-4
Phosphorothioic acid, O-(2,5-dichloro-4-nitrophenyl)O,O-dimethyl ester 84197-36-4
Phosphorothioic acid, O-(3,5-dichloro-4-nitrophenyl)O,O-dimethyl ester 50590-01-7
Phosphorothioic acid,O-(6-(2,6-dichlorophenoxy)-3-pyridazinyl) O,O-diethylester 53605-17-7
Phosphorothioic acid,O-(2,4-dichlorophenyl)-O,O-diethyl ester 97-17-6
Phosphorothioic acid, O-(2,4-dichlorophenyl) O-ethylester, potassium salt 97-17-6
Phosphorothioic acid, O-(2,4-dichlorophenyl) O-ethylS-methyl ester 6856-18-4
Phosphorodithioic acid, O,O-diisopropyl ester,S-ester with6-chloro-2-(mercaptomethyl)-3(2H)-pyridazinone 51356-17-3
Phosphorothioic acid, O-(2,4-dichlorophenyl) O-ethylS-propyl ester 38527-91-2
Phosphorothioic acid, S-((2,6-dichlorophenyl)methyl)O,O-diethyl ester 38527-91-2
Phosphorothioic acid,S-(((2,5-dichlorophenyl)thio)methyl) O,O-diethylester 14734-96-4
Phosphorothioic acid,S-(((2,5-dichlorophenyl)thio)-methyl) O,O-dimethylester 17578-36-8
Phosphorothioic acid, O-(2,6-dichloro-p-tolyl)O,O-dimethyl ester 57018-04-9
Phosphorothioic acid, S-1,2-dichlorovinyl O,O-diethylester 1885-91-2
Phosphorothioic acid, S-2,2-dichlorovinyl O,O-diethylester 1885-95-6
Phosphorothioic acid, O-2,2-dichlorovinylO,O-dimethyl ester 36560-17-5
Phosphorothioic acid,S-(((diethoxyphosphinothioyl)thio)methyl) O,O-diethylester 17356-42-2
Phosphorothioic acid, S-(2-diethylaminoethyl)O,O-cyclic trimethylene ester 58607-59-3
Phosphorodithioic acid, O,O-diethylS-(2-(methylamino)-2-oxoethyl) ester 2605-70-1
Phosphorodithioic acid, O,O-diisopropyl ester,S-ester with N-(2-mercaptoethyl) benzenesulfonamide 741-58-2
Phosphorothioic acid, S-(2-(diethylamino)ethyl)O,O-diethyl ester 78-53-5
Phosphorothioic acid, S-(2-(diethylamino)ethyl)O,O-diethyl ester, oxalate (1:1) 3734-97-2
Phosphorothioic acid,O-(2-(diethylamino)-6-methyl-4-pyrimidinyl)O,O-dimethyl ester 29232-93-7
Phosphorothioic acid, O,O-diethylO-(4-(1-((((butylamino)carbonyl)oxy)imino)ethyl)phenyl) ester 22936-20-5
Phosphorothioic acid, O,O-diethylS-(1-(1,3-dicarbethoxy)ethyl) ester 2667-33-6
Phosphorothioic acid, O,O-diethylO-(2,5-dichloro-4-(methylthio)phenyl) ester 21923-23-9
Phosphorothioic acid, O,O-diethylO-(4-((((((2-(diethylamino)ethyl)amino)carbonyl)oxy)imino) methyl)phenyl) ester 22941-86-2
Phosphorothioic acid, O,O-diethylO-(2-(diethylamino)-6-methyl-4-pyrimidinyl) ester 23505-41-1
Phosphorothioic acid, O,O-diethylS-(2-(diethylamino)-2-oxoethyl) ester 35841-65-7
Phosphorothioic acid, O,O-diethylS-(O,O-diethylphosphoramido)ethyl ester 23497-20-3
Phosphorodithioic acid, O,O-diisopropyl ester,S-ester with2-(mercaptomethyl)-6-methyl-3(2H)-pyridazinone 51356-10-6
Phosphorothioic acid, O,O-diethylS-diethylsulfonioethyl ester 51356-10-6
Phosphorothioic acid, O,O-diethylO-(4-(1-((((dimethylamino)carbonyl)oxy)imino)ethyl)phenyl) ester 22942-43-4
Phosphorothioic acid, O,O-diethylO-(4-(((((dimethylamino)carbonyl)oxy)imino)methyl)phenyl) ester 22942-23-0
Phosphorothioic acid, O,O-diethylS-(2-dimethylaminoethyl) ester 3147-20-4
Phosphorothioic acid, O,O-diethylO-(3-(dimethylamino)-4-nitrophenyl) ester 2799-95-3
Phosphorothioic acid, O,O-diethylS-(2-(dimethylamino)-2-oxoethyl) ester 34013-90-6
Phosphorothioic acid, O,O-diethylO-(6-(1,3-dimethylbutoxy)-3-pyridazinyl) ester 53605-02-0

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