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MSDS  : Phosphorodithioic acid, S,S'-methylene O,O,O',O'-tetraethyl ester
CAS  : 563-12-2
SYNONYMS  : * Bis(S-(diethoxyphosphinothioyl)mercapto)methane * Diethion * Embathion * ENT 24,105 * Ethanox * Ethiol 100 * Ethion * Ethodan * Ethopaz * Ethyl methylene phosphorodithioate * FMC-1240 * Fosfatox E * Fosfono 50 * Hylemox * KWIT * Methyleen-S,S'-bis(O,O-diethyl-dithiofosfaat) * S,S'-Methylen-bis(O,O-diaethyl-dithiophosphat) * Methylene-S,S'-bis(O,O-diaethyl-dithiophosphat) * S,S'-Methylene O,O,O',O'-tetraethyl phosphorodithioate * NIA 1240 * Niagara 1240 * Nialate * Phosphorodithioic acid, O,O-diethyl ester, S,S-diester with methanedithiol * Phosphotox E * Rhodocide * Rodocid * RP 8167 * O,O,O',O'-Tetraaethyl-bis(dithiophosphat) * O,O,O',O'-Tetraethyl S,S'-methylenebisphosphordithioate * O,O,O',O'-Tetraethyl-S,S'-methylenebisphosphorodithioate * Tetraethyl S,S'-methylene bis(phosphorothiolothionate) * O,O,O',O'-Tetraethyl S,S'-methylene di(phosphorodithioate) * Vegfru fosmite
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : TE4550000
CHEMICAL NAME : Phosphorodithioic acid, S,S'-methylene
O,O,O',O'-tetraethyl ester
CAS REGISTRY NUMBER : 563-12-2
BEILSTEIN REFERENCE NO. : 1804530
REFERENCE : 4-01-00-03093 (Beilstein Handbook Reference)
LAST UPDATED : 199712
DATA ITEMS CITED : 35
MOLECULAR FORMULA : C9-H22-O4-P2-S4
MOLECULAR WEIGHT : 384.49
WISWESSER LINE NOTATION : 2OPS&O2&S1SPS&O2&O2
COMPOUND DESCRIPTOR : Agricultural Chemical
Mutagen
Human
SYNONYMS/TRADE NAMES :
* Bis(S-(diethoxyphosphinothioyl)mercapto)methane
* Diethion
* Embathion
* ENT 24,105
* Ethanox
* Ethiol 100
* Ethion
* Ethodan
* Ethopaz
* Ethyl methylene phosphorodithioate
* FMC-1240
* Fosfatox E
* Fosfono 50
* Hylemox
* KWIT
* Methyleen-S,S'-bis(O,O-diethyl-dithiofosfaat)
* S,S'-Methylen-bis(O,O-diaethyl-dithiophosphat)
* Methylene-S,S'-bis(O,O-diaethyl-dithiophosphat)
* S,S'-Methylene O,O,O',O'-tetraethyl phosphorodithioate
* NIA 1240
* Niagara 1240
* Nialate
* Phosphorodithioic acid, O,O-diethyl ester, S,S-diester with
methanedithiol
* Phosphotox E
* Rhodocide
* Rodocid
* RP 8167
* O,O,O',O'-Tetraaethyl-bis(dithiophosphat)
* O,O,O',O'-Tetraethyl S,S'-methylenebisphosphordithioate
* O,O,O',O'-Tetraethyl-S,S'-methylenebisphosphorodithioate
* Tetraethyl S,S'-methylene bis(phosphorothiolothionate)
* O,O,O',O'-Tetraethyl S,S'-methylene di(phosphorodithioate)
* Vegfru fosmite

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - infant
DOSE/DURATION : 15700 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - changes in motor activity (specific assay)
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
TXMDAX Texas Medicine. (Texas Medical Assoc., 1801 N. Lamar Blvd., Austin,
TX 78701) V.60- 1964- Volume(issue)/page/year: 63,71,1967

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human
DOSE/DURATION : 100 ug/kg
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
22,286,1972

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 13 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHJOAV Pharmaceutical Journal. (Pharmaceutical Soc. of Great Britain, 1
Lambeth High St., London, SE1 7JN, UK) V.131- 1933-
Volume(issue)/page/year: 185,361,1960

TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 864 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave.,
Willoughy, OH 44094) Volume(issue)/page/year: -,C128,1991

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 62 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
14,515,1969

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 26 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 129,699,1968

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 55 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag
New York, Inc., 1971 Volume(issue)/page/year: -,367,1971

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 40 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel,"
Perkow, W., Berlin, Verlag Paul Parey, 1971-1976 Volume(issue)/page/year:
-,-,1971/1976

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 35 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 129,699,1968

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 40 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel,"
Perkow, W., Berlin, Verlag Paul Parey, 1971-1976 Volume(issue)/page/year:
-,-,1971/1976

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 915 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel,"
Perkow, W., Berlin, Verlag Paul Parey, 1971-1976 Volume(issue)/page/year:
-,-,1971/1976

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - wild bird species
DOSE/DURATION : 45 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
21,315,1972

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 675 mg/kg/90D-C
TOXIC EFFECTS :
Blood - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 8,173,1988

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 182 mg/kg/1Y-C
TOXIC EFFECTS :
Blood - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 8,173,1988

*** REVIEWS ***

ACGIH TLV-TWA 0.4 mg/m3 (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997

TOXICOLOGY REVIEW
AQMOAC Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25,
1969-75(?). Discontinued. Volume(issue)/page/year: #73-19,1973

TOXICOLOGY REVIEW
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.)
V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973

TOXICOLOGY REVIEW
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year:
63,1,1976

*** U.S. STANDARDS AND REGULATIONS ***

EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989

*** OCCUPATIONAL EXPOSURE LIMITS ***

OEL-AUSTRALIA:TWA 0.4 mg/m3;Skin JAN 1993

OEL-BELGIUM:TWA 0.4 mg/m3;Skin JAN 1993

OEL-FRANCE:TWA 0.4 mg/m3;Skin JAN 1993

OEL-THE NETHERLANDS:TWA 0.4 mg/m3;Skin JAN 1993

OEL-SWITZERLAND:TWA 0.4 mg/m3 JAN 1993

OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV

OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO ETHION-air:10H TWA 0.4 mg/m3 (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84542
No. of Facilities: 12 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 72 (estimated)

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test

EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP
reversion

EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis

EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA
without S9

On EPA IRIS database

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Phosphorodithioic acid, S-2-(isopropylthio)ethylO,O-dimethyl ester 36614-38-7
Phosphorodithioic acid, O-methylS,S-bis(1-methylethyl) ester 99559-84-9
Phosphorodithioic acid, O-methyl S,S-dipropyl ester 4104-02-3
Phosphorodithioic acid, O,O-diethylS-(2-(methylthio)ethyl) ester 3772-46-1
Phosphorodithioic acid, S,S'-methyleneO,O,O',O'-tetraethyl ester 563-12-2
Phosphorodithioic acid, O-methylS-(2-(methylamino)-2-oxoethyl) ester, sodium salt,dihydrate 563-12-2
Phosphorodithioic acid, O-methylS-(N-methylcarbamoylmethyl) ester, potassium salt 20253-72-9
Phosphorodithioic acid, O-methyl O-propyl ester,S-ester with N-(mercaptomethyl)phthalimide 19133-14-3
Phosphorodithioic acid, S,S'-thiodiethyleneO,O,O',O'-tetraethyl ester 19133-14-3
Phosphorodithioic acid, O,S,S-triethyl ester 2404-78-6
Phosphorodithioic acid, O,O,S-trimethyl ester 2953-29-9
Phosphorodithioic acid, O,S,S-trimethyl ester 22608-53-3
Phosphorodithioic acid, O,S,S-tripropyl ester 74125-01-2
Phosphorodithioic acid, zinc salt 19210-06-1
Phosphorodithioic acid, O,O-diethylS-((5-(methylthio)-1,3,4-thiadiazol-2-yl)methyl)ester 38090-93-6
Phosphorofluoridic acid 13537-32-1
Phosphorofluoridic acid, bis(1,3-dimethylbutyl) ester 311-60-4
Phosphorofluoridic acid, bis(2-fluoroethyl) ester 358-88-3
Phosphorofluoridic acid, bis(1-methylethyl) ester 55-91-4
Phosphorofluoridic acid, di-sec-butyl ester 625-17-2
Phosphorofluoridic acid, dicyclohexyl ester 587-15-5
Phosphorofluoridic acid, diethyl ester 358-74-7
Phosphorofluoridic acid, dimethyl ester 5954-50-7
Phosphorofluoridic acid, disodium salt 10163-15-2
Phosphorofluoridic acid, ethyl ester, potassium salt 358-69-0
Phosphorodithioic acid, O,O-diethyl S-m-nitrobenzylester 13286-40-3
Phosphorofluoridic acid, ethyl methyl ester 430-05-7
Phosphorofluoridothioic acid, O-p-chlorophenylO-phenyl ester 430-05-7
Phosphorofluoridothioic acid, O,O-diisopropyl ester 1000-22-2
Phosphoromorpholinothioic acid, O-methylS-(O',O'-diethylphosphoramido)ethyl ester 21988-58-9
Phosphoromorpholinothioic acid, O-methylS-(dipropylaminophosphoramido)ethyl ester 63717-19-1
Phosphoroselenoic acid, Se-(2-(diethylamino)ethyl)O,O-diethyl ester 10161-85-0
Phosphoroselenoic acid, O,O-diethylSe-(2-(ethylthio)ethyl) ester 118871-70-8
Phosphoroselenoic acid, O,O-diethylSe-(2-(methylthio)ethyl) ester 119015-23-5
Phosphoroselenoic acid, O,O-diethyl ester, sodiumsalt 7452-29-1
Phosphorotetrathioic acid, 2-(diethylamino)ethyldimethyl ester, oxalate (1:1) 4980-02-3
Phosphorodithioic acid, O,O-diethyl S-p-nitrobenzylester 13286-49-2
Phosphorotetrathioic acid, S,S-dimethylS-(prop-2-ynyl) ester 17118-79-5
Phosphorothioate 15181-41-6
Phosphoro(thiocyanatidic) acid, thio-, diethyl ester 26190-34-1
Phosphorothioic acid 13598-51-1
Phosphorothioic acid,O-(4-(1-((acetyloxy)imino)ethyl)-3-methylphenyl)O,O-diethyl ester 22936-44-3
Phosphorothioic acid,O-(4-(1-((acetyloxy)imino)ethyl)phenyl) O,O-diethylester 22941-84-0
Phosphorothioic acid, O-(p-(N-acetylsulfamoyl)phenyl)O,O-dimethyl ester 22941-84-0
Phosphorothioic acid,S-(N-(1-adamantylmethylamidino)methyl) ester,monosodium salt 69804-02-0
Phosphorothioic acid, O-(4-allyl-2-methoxyphenyl)O,O-dimethyl ester 15037-64-6
Phosphorothioic acid, S-(1-amidinobutyl) ester,monosodium salt 69803-91-4
Phosphorodithioic acid, O,O-diethylS-1,4-oxathian-3-yl ester 38188-83-9
Phosphorothioic acid, S-(1-amidinoethyl) ester,monosodium salt 69804-10-0
Phosphorothioic acid, S-(amidinomethyl) ester,monosodium salt 19412-49-8

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