HOFFMAN-LA ROCHE ROCHE LABORAT -- 55512 PYRIDOSTIGMINE BROMIDE
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Material Safety Data Sheet
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MSDS Num: BXKXZ
MSDS NAME: 55512 PYRIDOSTIGMINE BROMIDE
Responsible Party
Name: HOFFMAN-LA ROCHE INC ROCHE LABORATORIES DIV
Address: 340 KINGSLAND ST
City: NUTLEY NJ 07110-1199
Info Phone: 800-526-1247/201-235-6660
Emergency Phone Number: 201-235-6660/800-526-6367
Preparer's Name: HESHAM M SOLIMAN
Review Ind: Y
Published: Y
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Preparer Co. when other than Responsible Party Co.
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Name: HOFFMAN-LA ROCHE INC
Address: 340 KINGSLAND ST
City: NUTLEY NJ 07110-1141
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Contractor Summary
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Name: HOFFMAN-LA ROCHE INC
Address: 340 KINGSLAND ST
City: NUTLEY NJ 07110-1141
Phone: 201-235-2323
Name: ROCHE LABORATORIES, DIV. OF HOFFMANN-LA ROCHE INC.
Address: 340 KINGSLAND STREET
City: NUTLEY NJ 07110-1199
Phone: 201-235-6660/800-526-6367
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Ingredients
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Cas: 101-26-8
RTECS #: UU5270000
Name: PYRIDOSTIGMINE BROMIDE *95-1*
% Wt: 100
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Health Hazards Data
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LD50 LC50 Mixture: ORAL LD50(RAT): 80 MG/KG
Route Of Entry Inds - Inhalation: YES
Skin: NO
Ingestion: YES
Carcinogenicity Inds - NTP: NO
IARC: NO
OSHA: NO
Effects of Exposure: MAY CAUSE SKIN REACTION/IRRITATION, CARDIOVASCULAR
EFFECTS, CARDIAC ARREST, RESPIRATORY EFFECTS, RESPIRATORY ARREST,
MUSCULOSKELETAL EFFECTS, SKELETAL ABNORMALITIES, EYE IRRITATION, IMPAIRMENT
OF VISI ON. HARMFUL IF SWALLOWED.
Explanation Of Carcinogenicity: NONE
Signs And Symptions Of Overexposure: HEADACHES, IRRITATION, CRACKS IN LIP &
MOUTH, DRY/PEELING/ITCHING/REDNESS OF THE SKIN, INCREASE/DECREASE IN BLOOD
PRESSURE, IRREGULAR HEARTBEAT, CHEST PAIN, DIFFICULTY BREATHING, COUGHING,
WHEEZING, M USCLE WEAKNESS/PAIN, INFLAMMATION.
Medical Cond Aggravated By Exposure: HYPERSENSITIVITY TO MATERIAL, GI
CONDITIONS, KIDNEY CONDITIONS, IMPAIRED RENAL FUNCTION, ASTHMA, HEART
CONDITIONS.
First Aid: INHALATION: REMOVE TO FRESH AIR. GIVE CPR/OXYGEN IF NEEDED.
ADMINISTERING SHOULD BE DONE BY QUALIFIED PERSONNEL. SKIN: IMMEDIATELY WASH
W/SOAP & PLENTY OF WATER. EYES: IMMEDIATELY FLUSH W/PLENTY OF WA TER FOR
15 MINS. INGESTION: DON'T INDUCE VOMITING UNLESS DIRECTED BY MEDICAL
PERSONNEL. NEVER GIVE ANYTHING BY MOUTH TO AN UNCONSCIOUS PERSON. OBTAIN
MEDICAL ATTENTION IN ALL CASES.
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Handling and Disposal
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Spill Release Procedures: SHUT OFF SOURCE/LEAK SAFELY. SCOOP/SHOVEL MATERIAL
INTO SUITABLE LABELED OPEN HEAD DRUM. SECURE THE DRUM COVER & MOVE
CONTAINER TO A SAFE HOLDING AREA. CLEAN AREA THOROUGHLY.
Waste Disposal Methods: DISPOSE OF AS A HAZARDOUS WASTE IN A LICENSED HAZARDOUS
WASTE INCINERATOR IAW/LOCAL, STATE & FEDERAL REGULATIONS. EMPTY
CONTAINERS MUST BE TRIPLE RINSED PRIOR TO DISPOSAL/RECYCLING/REUSE. UN 2811.
Handling And Storage Precautions: USE ADEQUATE VENTILATION. STORE IN A COOL,
DRY AREA. KEEP CONTAINER TIGHTLY CLOSED WHEN NOT IN USE.
Other Precautions: DON'T GET IN EYES, ON SKIN/CLOTHING. DON'T BREATHE DUST.
POST THE WORK AREA & LIMIT ACCESS TO AUTHORIZED PERSONNEL ONLY. PREVENT
THE ACCUMULATION OF DUST IN WORK AREA.
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Fire and Explosion Hazard Information
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Extinguishing Media: WATER, CO2, DRY CHEMICAL, FOAM
Fire Fighting Procedures: WEAR NIOSH/MSHA APPROVED POSITIVE PRESSURE, SCBA
& FULL PROTECTIVE TURN OUT GEAR. USE WATER TO KEEP CONTAINERS COOL.
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Control Measures
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Respiratory Protection: HALF FACE, NEGATIVE PRESSURE AIR PURIFYING, TOIX
DUST/MIST/FUME HIGH EFFICIENCY FILTER RESPIRATOR. PRODUCTION OPERATIONS:
SUPPLIED AIR FULL FACEPIECE RESPIRATOR/SUPPLIED AIR HOOD IS REQUIRED.
Ventilation: LOCAL VENTILATION IS REQUIRED. USE IN LAB HOOD.
Protective Gloves: PLASTIC/RUBBER
Eye Protection: SAFETY GLASSES/GOGGLES
Other Protective Equipment: DISPOSABLE COVERALLS, LAB COAT.
Work Hygienic Practices: REMOVE/LAUNDER CONTAMINATED CLOTHING & SHOES BEFORE
REUSE. WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health: PH: 3.5 AT 10% AQUEOUS SOLUTION. MELTING POINT:
309.2-314.6F. ORAL LD50 IS FOR PYRIDOSTIGMINE BROMIDE.
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Physical/Chemical Properties
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M.P/F.P Text: (SEE SUPP)
PH: (SUPP)
Solubility in Water: COMPLETE
Appearance and Odor: WHITE/PRACTICALLY WHITE CRYSTALLINE POWDER W/AGREEABLE
CHARACTERISTIC ODOR
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Reactivity Data
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Stability Indicator: YES
Stability Condition To Avoid: HUMIDITY
Hazardous Decomposition Products: CO, CO2, OXIDES OF NITROGEN, HYDROGEN
BROMIDE, BROMINATED COMPOUNDS.
Hazardous Polymerization Indicator: NO
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Toxicological Information
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Ecological Information
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MSDS Transport Information
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Regulatory Information
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Other Information
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HAZCOM Label
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MSDS NAME: 55512 PYRIDOSTIGMINE BROMIDE
Company: HOFFMAN-LA ROCHE INC
Street: 340 KINGSLAND ST
City: NUTLEY NJ
Zipcode: 07110-1141
Health Emergency Phone: 201-235-6660/800-526-6367
Label Required IND: Y
Date Of Label Review: 12/16/1998
Status Code: C
Label Date: 12/16/1998
Origination Code: G
Hazard And Precautions: MAY CAUSE SKIN REACTION/IRRITATION, CARDIOVASCULAR
EFFECTS, CARDIAC ARREST, RESPIRATORY EFFECTS, RESPIRATORY ARREST,
MUSCULOSKELETAL EFFECTS, SKELETAL ABNORMALITIES, EYE IRRITATION, IMPAIRMENT
OF VISI ON. HARMFUL IF SWALLOWED.
HEADACHES, IRRITATION, CRACKS IN LIP &
MOUTH, DRY/PEELING/ITCHING/REDNESS OF THE SKIN, INCREASE /DECREASE IN BLOOD
PRESSURE, IRREGULAR HEARTBEAT, CHEST PAIN, DIFFICULTY BREATHING, COUGHING,
WHEEZING, MUSCLE WEAKNESS/PAIN, INFLAMMATION.
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Disclaimer (provided with this information by the compiling agencies): This
information is formulated for use by elements of the Department of Defense.
The United States of America in no manner whatsoever expressly or implied
warrants, states, or intends said information to have any application, use or
viability by or to any person or persons outside the Department of Defense
nor any person or persons contracting with any instrumentality of the United
States of America and disclaims all liability for such use. Any person
utilizing this instruction who is not a military or civilian employee of the
United States of America should seek competent professional advice to verify
and assume responsibility for the suitability of this information to their
particular situation regardless of similarity to a corresponding Department
of Defense or other government situation.
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