===================== Product Identification =====================
MSDS NAME:BICNU FOR IV INFUSION
NIIN:01-189-1742
Kit Part:Y
MSDS Number: BSQDK
=== Responsible Party ===
Company:E R SQUIBB & SONS (BRISTOL-MYERS)
Address:5 GORDIS RD BLDG 124
Box:191
City:NEW BRUNSWICK
State:NJ
ZIP:08903
Country:US
Info Phone Num:800-332-2056/908-519-3843
Emergency Phone Num:201-519-2885/609-921-4081
CAGE:GO233
=== Contractor Identification ===
Company:E R SQUIBB & SONS
Address:5 GORDIS RD BLDG 124
Box:191
City:NEW BRUNSWICK
State:NJ
ZIP:08903
Country:US
Phone:609-921-4081
CAGE:GO233
Company:E R SQUIBB MEDATOPE DIV
Address:5 GORDIS RD BLDG 124
Box:191
City:NEW BRUNSWICK
State:NJ
ZIP:08903
Country:US
Phone:609-921-4081
CAGE:4T649
============= Composition/Information on Ingredients =============
Name:ETHANOL (ETHYL ALCOHOL), TECSOL, ALCOHOL
CAS:64-17-5
RTECS #:KQ6300000
Fraction by Wt: 100%
Other REC Limits:1900 MG/CUM
OSHA PEL:1000 PPM
ACGIH TLV:1000 PPM
===================== Hazards Identification =====================
LD50 LC50 Mixture:ORAL LD50 (RAT): 20 MG/KG
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:EYE IRRITANT, CONJUNCTIVITIS.
THERAPEUTIC DOSES MAY INCLUDE DELAYED HEMATOLOGIC/PULMONARY/OCULAR
TOXICITY, MILD & REVERSIBLE HEPATOTOXICITY, RENAL DAMAGE, LEUKEMIA
& BONE MARROW DYSPLASIA. ETHYL ALCOH OL IS A CNS DEPRESSION &
IRRITANT.
Explanation of Carcinogenicity:NONE
Effects of Overexposure:THERAPEUTIC DOSES MAY INCLUDE NAUSEA &
VOMITING.
Medical Cond Aggravated by Exposure:BLOOD DISORDERS, GASTROINTESTINAL
ILLNESSES, PULMONARY DISEASE, KIDNEY DISEASE OR HEPATIC DISEASE
======================= First Aid Measures =======================
First Aid:INGESTION: INDUCTION OF VOMITING SHOULD BE CONSIDERED FOR
SIGNIFICANT INGESTIONS IF CONSCIOUS/NOT CONVULSING. NEVER GIVE
ANYTHING BY MOUTH IF UNCONSCIOUS. INHALATION: REMOVE TO FRESH AIR.
GIVE CPR/OXY GEN AS NEEDED. SKIN: FLUSH W/PLENTY OF WATER. USE SOAP
IF AVAILABLE. REMOVE CONTAMINATED CLOTHING/SHOES. EYES: FLUSH
W/PLENTY OF WATER FOR AT LEAST 15 MINS. OBTAIN MEDICAL ATTENTION IN
ALL CASES.
===================== Fire Fighting Measures =====================
Flash Point:55F
Lower Limits:3.3% SUPPL.
Upper Limits:19% SUPPL.
Extinguishing Media:WATER, CO2, FOAM OR DRY CHEMICAL
Fire Fighting Procedures:WEAR SELF-CONTAINED BREATHING APPARATUS, FLAME
& CHEMICAL RESISTANT CLOTHING, BOOTS & GLOVES. EVACUATE PERSONNEL
TO UPWIND DIRECTION.
Unusual Fire/Explosion Hazard:REMOVE UNNEEDED MATERIAL & COOL
CONTAINERS W/WATER FROM A MAXIMUM DISTANCE. FINE POWDERS ARE
CONSIDERED TO BE COMBUSTIBLE. AUTOIGNITION TEMPERATURE: 685F.
================== Accidental Release Measures ==================
Spill Release Procedures:SMALL: WIPE LIQUIDS W/ABSORBENT GAUZE PADS.
WIPE SOLIDS W/WET ABSORBENT GAUZE. CLEAN, USING DETERGENT & WATER.
LARGE: COVER LIQUID W/ABSORBENT SHEETS, CONTROL PADS OR PILLOWS.
COVER W/DAMP CLOTHS/TOWE LS.
====================== Handling and Storage ======================
Handling and Storage Precautions:SHIP & STORE UNDER REFRIGERATION (2C
TO 8C). DON'T BREAK VIALS OR SPILL CONTENTS. INCOMPATIBLE
W/POLYVINYL CHLORIDE CONTAINERS.
Other Precautions:WHEN STORED IN ORIGINAL CONTAINER, DRUG IS STABLE TO
THE EXPIRATION DATE ON THE LABEL OF THE PRODUCT. PROVIDE BONDING &
GROUNDING PROTECTION TO CONTROL STATIC CHANGES. FINE POWDERS ARE
COMBUSTIBLE.
============= Exposure Controls/Personal Protection =============
Respiratory Protection:WEAR AN APPROVED DUST RESPIRATOR W/HIGH
EFFICIENCY DUST FILTER OR POWERED AIR-PURIFYING RESPIRATOR. SCBA
SHOULD BE AVAILABLE FOR EMERGENCIES.
Ventilation:LOCAL MECHANICAL EXHAUST TO MINIMIZE EXPOSURE. A BIOLOGICAL
SAFETY CABINET SHOULD BE USED FOR PREPARATION OF THIS DRUG
Protective Gloves:DISPOSABLE SURGICAL LATEX
Eye Protection:CHEMICAL SAFETY GOGGLES
Other Protective Equipment:IMPERVIOUS DISPOSABLE COVERALLS W/CLOSED
FRONT, LONG SLEEVES & ELASTIC CUFFS & BOOTS. DOUBLE GLOVING IS
RECOMMENDED.
Work Hygienic Practices:WASH HANDS, FOREARMS, & FACE THOROUGHLY AFTER
HANDLING & BEFORE EATING, SMOKING, USING LAVATORY & AT THE END OF
DAY.
Supplemental Safety and Health
BICNU IS PACKAGED AS TWO VIALS. EACH PACKAGE INCLUDES A VIAL CONTAINING
100 MG CARMUSTINE & A VIAL CONTAINING 3 ML ETHYL ALCOHOL AS A
DILUENT. PRODUCT USE: CYTOTOXIC ANTINEOPLASTIC AGENT. DATA GIVEN I
S MAINLY FOR ETHYL ALCOHOL.
================== Physical/Chemical Properties ==================
Boiling Pt:B.P. Text:173F
Melt/Freeze Pt:M.P/F.P Text:-179F
Vapor Pres:40
Vapor Density:1.59
Spec Gravity:0.7893
pH:5.6-6
Evaporation Rate & Reference:(CCL4 = 1): 1.4
Solubility in Water:MISCIBLE
Appearance and Odor:CLEAR, COLORLESS VOLATILE LIQUID
================= Stability and Reactivity Data =================
Stability Indicator/Materials to Avoid:YES
OXIDIZERS
Stability Condition to Avoid:OPEN FLAMES, SPARKS, & OTHER IGNITION
SOURCES
Hazardous Decomposition Products:CO, CO2, HYDROCHLORIC ACID, NITROGEN
OXIDES & POSSIBLY SOME CARCINOGENIC COMPOUNDS
==================== Disposal Considerations ====================
Waste Disposal Methods:DISPOSE OF IN ACCORDANCE W/LOCAL, STATE, &
FEDERAL REGULATIONS. INCINERATION IS RECOMMENDED. UN1992.
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.
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