LD50 LC50 Mixture:ORAL LD50 (RAT): 135 MG/KG
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:POISONOUS BY SKIN CONTACT/INHALATION &
SWALLOWING. POSSIBLE ALLERGIC REACTION TO POWDER IF
INHALED/INGESTED/SKIN CONTACT. EYES/SKIN/RESPIRATORY TRACT
IRRITANT. SIGNS OF TOXICITY: ULCERATION OF THE MOU TH,
THROBOCYTOPENIA/ANEMIA/BONE MARROW DEPRESSION/LIVER/KIDNEY
DAMAGE/GI ULCERATION/PULMONARY/NEUROTOXIC (SEE SUPP).
Explanation of Carcinogenicity:NONE
Effects of Overexposure:IRRITATION, NAUSEA, VOMITING, DIARRHEA,
ALOPECIA, SKIN RASH.
======================= First Aid Measures =======================
First Aid:INHALATION: REMOVE TO FRESH AIR. INGESTION: FLUSH MOUTH OUT
W/WATER. SKIN: FLUSH AREA W/WATER. EYES: FLUSH W/WATER. OBTAIN
MEDICAL ATTENTION IN ALL CASES.
===================== Fire Fighting Measures =====================
Extinguishing Media:CO2, DRY CHEMICAL, FOAM AS APPROPRIATE FOR
SURROUNDING FIRES.
Fire Fighting Procedures:USE SELF CONTAINED BREATHING APPARATUS &
PROTECTIVE CLOTHING.
Unusual Fire/Explosion Hazard:DRY POWDER IS ASSUMED TO BE COMBUSTIBLE.
IT'S ADVISABLE TO GROUND MECHANICAL EQUIPMENT TO DISSIPATE BUILDUP
OF STATIC ELECTRICITY.
Spill Release Procedures:WEAR RECOMMENDED PERSONAL PROTECTIVE
EQUIPMENT. VACUUM W/A VACUUM CLEANER HAVING A HIGH EFFICIENCY
PARTICULATE (HEPA) FILTER/ABSORB LIQUID W/PAPER TOWELS. WIPE
WORKING SURFACES TO DRYNESS, THEN WASH W /SOAP & WATER.
====================== Handling and Storage ======================
Handling and Storage Precautions:STORE IN A TIGHTLY CLOSED CONTAINERS
IN A COOL AREA. AVOID ALL FORMS OF UNPROTECTED CONTACT.
Respiratory Protection:NIOSH APPROVED RESPIRATOR
Ventilation:LOCAL EXHAUST RECOMMENDED
Protective Gloves:DISPOSABLE SURGICAL LATEX
Eye Protection:SAFETY GOGGLES
Other Protective Equipment:DISPOSABLE PROTECTIVE APPAREL.
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE
REUSE.
Supplemental Safety and Health
METHOTREXATE SODIUM FOR INJECTION, IS STERILE NONPYROGENIC, ISOTONIC,
SOLUTION OF METHOTREXATE PREPARED AS SODIUM SALT. HELATH HAZARDS
CONT'D: SUPPRESSION OF OVARIAN/TESTICULAR FUNCTION. NEUROTOXIC RE
ACTIONS ARE ASSOCIATED W/INTRATHECAL USE OF METHOTREXATE.
EYES/SKIN/RESPIRATORY TRACT: IRRITANT.
Appearance and Odor:YELLOW TO ORANGE LYOPHILIZED POWDER.
================= Stability and Reactivity Data =================
Stability Indicator/Materials to Avoid:YES
Stability Condition to Avoid:LIGHT
Hazardous Decomposition Products:TOXIC FUMES WHEN HEATED TO
DECOMPOSITION.
Waste Disposal Methods:PLACE DRUG-SOLID ABSORBENTS INTO A LEAK-PROOF
CONTAINER & LABEL PROPERLY. THOUGH NOT EPA REGULATED, WASTE SHOULD
BE DISPOSED OF IAW/FEDERAL, STATE & LOCAL REGULATIONS.
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.