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Material Safety Data Sheet
L-Asparaginase
1: Chemical Product and Company Identification
Product Name: L-Asparaginase
Contact information:
Catalog Code: 508087
bioWORLD
CAS#: 9015-68-3
4150 Tuller Rd
Suite 228, Dublin, OH 43017, USA
RTECS: CI9000000
For information, call: 614-792-8680
TSCA: TSCA 8(b) inventory : No products were found.
Fax Number: 614-792-8685
Order Online:www.bio-world.com
CI#: Not available.
E-mail : save@bio-world.com
Synonym: L-Asnase; Asparaginase; l-Asparaginase X; L-
Asparagine amidohydrolase; Colaspase; Crasnitin; E. C. 3.5.1.1; In case of a chemical emergency, contact local
Elspar; Kidrolase; Leucogen; Leunase; MK-965; NSC-109229;
hospital.
Paronal; Re 82-Tad-15
For non-emergency assistance,call: 1-800-860-9729
Chemical Name: L-Asparaginase
Chemical Formula: Not available.
2: Composition and Information on Ingredients
Composition:
Name CAS# % by Weight
L-Asparaginase 9015-68-3 -
Toxicological Data on Ingredients:
LD50 (Oral, Rat): 7500 ku/kg
LD50 (Intraperitoneal, Rat): 8204 mg/kg
LD50 (Subcutaneous, Rat): 8204 mg/kg
LD50 (Intravenous, Rat): 7568 mg/kg
LD50 (Oral, Mouse): 5000 ku/kg
3: Hazards Identification
Potential Acute Health Effects: Harmful. May cause sensitization by inhalation and skin contact. Possible risk of harm
to the unborn child.
Target organ(s): Liver. Pancreas.
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Potential Chronic Health Effects:
CARCINOGENIC EFFECTS: Neoplastic by RTECS criteria.
MUTAGENIC EFFECTS: Not available.
TERATOGENIC EFFECTS: Suspected teratogen.
DEVELOPMENTAL TOXICITY: Effects on fertility.
4: First Aid Measures
Eye Contact: In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate
flushing by separating the eyelids with fingers. Call a physician.
Skin Contact: In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated
clothing and shoes. Call a physician.
Serious Skin Contact: Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek
medical attention.
Inhalation: If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
Serious Inhalation: Not available.
Ingestion: If swallowed, wash out mouth with water provided person is conscious. Call a physician.
Serious Ingestion: Not available.
5: Fire and Explosion Data
Flammability of the Product: May be combustible at high temperature.
Auto-Ignition Temperature: Not available.
Flash Points: Not available.
Flammable Limits: Not available.
Product of Combustion: Nature of decomposition products not known.
Fire Hazards in Presence of Various Substances: Not available.
Explosion Hazards in Presence of Various Substances:
Not available.
Fire Fighting Media and Instructions:
SMALL FIRE: Dry chemical powder.
LARGE FIRE: Water spray. Carbon dioxide, dry chemical powder, or appropriate foam.
Special Remarks on Fire Hazards: Not available.
Special Remarks on Explosion Hazards: Not available.
6: Accidental Release Measures
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Small Spill: Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site
after material pickup is complete.
Large Spill: Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading
water on the contaminated surface and allow to evacuate through the sanitary system.
7: Handling and Storage
Precautions: Avoid breathing dust. Avoid contact with eyes, skin, and clothing. Avoid prolonged or repeated exposure.
Storage: Keep tightly closed. Store at 2-8掳C
8: Exposure Controls/Personal Protection
Engineering Controls: Use only in a chemical fume hood. Safety shower and eye bath.
Personal Protection: Respiratory : Government approved respirator.
Hand: Chemical resistant gloves.
Eye: Safety glasses.
Personal Protection in Case of a Large Spill: Splash goggles. Full suit. Boots. Dust respirator. Gloves.
Exposure Limits: Not available.
9: Physical and Chemical Properties
Physical State and Appearance: Solid (Lyophilized powder).
Odor: Not available.
Taste: Not available.
Molecular Weight: 31731 Dalton
Color: White.
pH(1% soln/water): Not available.
Boiling Point: Not available.
Melting Point: Not available.
Critical Temperature: Not available.
Specific Gravity: Not available.
Vapour Pressure: Not available.
Vapor Density: Not available.
Volatility: Not available.
Odor Threshold: Not available.
Water/Oil Dist. Coeff: Not available.
Ionicity (in Water): Not available.
Dispersion Properties: Not available.
Solubility: Not available.
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10: Stability and Reactivity Data
Stability: Stable.
Instability Temperature: Not available.
Conditions of Instability: Not available.
Incompatibility with various substances: Oxidizing agents.
Corrosivity: Not available.
Special Remarks on Reactivity: Not available.
Special Remarks on Corrosivity: Not available.
Polymerization: Will not occur.
11:Toxicological Information
Routes of Entry: Skin contact. Eye contact. Ingestion. Inhalation.
Toxicity to Animals:
LD50 (Oral, Rat): 7500 ku/kg
LD50 (Intraperitoneal, Rat): 8204 mg/kg
LD50 (Subcutaneous, Rat): 8204 mg/kg
LD50 (Intravenous, Rat): 7568 mg/kg
LD50 (Oral, Mouse): 5000 ku/kg
LD50 (Intraperitoneal, Mouse): 334 g/kg
LD50 (Subcutaneous, Mouse): 345 g/kg
Chronic Effects on Humans: Carcinogen: Tumorigenic (Neoplastic by RTECS criteria). Lungs, thorax, or respiration or
blood tumors.
Teratogen: Laboratory experiments have shown teratogenic effects. Effects on embryo or fetus (Fetal death).
Reproductive hazard: Effects on fertility (Post-implantation mortality (e.g., dead and/or resorbed implants per total number of
implants).
Other Toxic Effects on Humans: Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
Special Remarks on Toxicity to Animals: Not available.
Special Remarks on Chronic Effects on Humans: CNS depression. Nausea, headache, and vomiting. Exposure can
cause: Other symptoms may include anorexia, chills, fever, weight loss, abdominal cramps, hyperglycemia, pancreatitis,
bone marrow depression, a decrease in blood concentration of fibrinogen depressing the clotting mechanisms, and liver and
kidney damage. Inhibits protein synthesis in various tissues of the body.
Special Remarks on other Toxic Effects on Humans: Respiratory: May cause allergic respiratory reaction. Skin: May
cause allergic skin reaction.
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12: Ecological Information
Ecotoxicity: Not available.
BOD5 and COD: Not available.
Product of Biodegradation: Not available.
Toxicity of the Products of Biodegradation: Not available.
Special Remarks on the Products of Biodegradation: Not available.
13: Disposal Considerations
Waste Disposal: Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the
material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Observe
all federal, state, and local environmental regulations.
14: Transport Information
DOT Classification: Not a DOT controlled material.
Identification: Not available.
Special Provisions for Transport: Not available.
15: Other Regulatory Information
Federal and State Regulations: TSCA 8(b) inventory : No products were found.
Other Regulations: EU ADDITIONAL CLASSIFICATION
Symbol of Danger: Xn
Indication of Danger: Harmful.
R: 42/43-63
Risk Statements: May cause sensitization by inhalation and skin contact. Possible risk of harm to the unborn child.
S: 22-36/37-45
Safety Statements: Do not breathe dust. Wear suitable protective clothing and gloves. In case of accident or if you feel
unwell, seek medical advice immediately (show the label where possible).
Other Classifications:
WHMIS(Canada): Not available.
DSCL(EEC): Not available.
HMIS(U.S.A):
Health Hazard: 3
Fire Hazard: 0
Reactivity: 0
Personal Protection:
National Fire Protection Association (U.S.A):
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Health: 3
Flammability: 0
Reactivity: 0
Specific hazard:
Protective Equipment: Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.
Safety goggles.
16: Other Information
References: Not available.
Other Special Considerations: Not available.
Created: 08/12/2006 11:10:11 AM
Last Updated: 08/12/2006 11:10:11 AM
Disclaimer
This product is offered by bioWORLD for research, laboratory or further manufacturing use. Not for human use or
consumption.
The information above is believed to be accurate and represents the best information currently available to us. However,we
make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we
assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the
information for their particular purposes.In no event shall Bio-World.com be liable for any claims, losses, or damages of any
third party or for lost profits or any special, indirect,incidental,consequential or exemplary damages, howsoever arising,
even if Bio-World.com has been advised of the possibility of such damages.
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