**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
| 67-66-3 |Chloroform | >99 | 200-663-8 |
+----------------+--------------------------------------+----------+-----------+
Hazard Symbols: XN
Risk Phrases: 22 38 40 48/20/22
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Appearance: clear, colorless.
Caution! Light sensitive. Mutagen. May be harmful if swallowed. This
substance has caused adverse reproductive and fetal effects in
animals. May cause central nervous system depression. May cause
cardiac disturbances. Causes eye and skin irritation. Causes
digestive and respiratory tract irritation. May cause cancer based on
animal studies.
Target Organs: Blood, kidneys, heart, central nervous system, liver,
gastrointestinal system, cardiovascular system, excretory system.
Potential Health Effects
Eye:
Causes moderate eye irritation. Contact with liquid causes
immediate burning pain, tearing, and reddening of the conjunctiva.
Skin:
Causes mild skin irritation.
Ingestion:
Causes gastrointestinal irritation with nausea, vomiting and
diarrhea. May cause cardiac disturbances. May cause hallucinations
and distorted perceptions.
Inhalation:
Inhalation of high concentrations may cause central nervous system
effects characterized by headache, dizziness, unconsciousness and
coma. May cause cardiac sensitization and possible failure.
Inhalation of large amounts may cause respiratory stimulation,
followed by respiratory depression, convulsions and possible death
due to respiratory paralysis. May be absorbed through the lungs.
Causes irritation of the mucous membrane and upper respiratory
tract.
Chronic:
Possible cancer hazard based on tests with laboratory animals.
Prolonged or repeated skin contact may cause dermatitis. May cause
reproductive and fetal effects. Effects may be delayed. Laboratory
experiments have resulted in mutagenic effects. Toxicity may be
increased by exposure to alcohol, steroids, and ketones. Prolonged
exposure may cause liver, kidney, and heart damage.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of soap and water for at
least 15 minutes while removing contaminated clothing and shoes. Wash
clothing before reuse.
Ingestion:
Do NOT induce vomiting. If victim is conscious and alert, give 2-4
cupfuls of milk or water. Never give anything by mouth to an
unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure to fresh air
immediately. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen.
Notes to Physician:
Causes cardiac sensitization to endogenous catelcholamines which may
lead to cardiac arrhythmias. Do NOT use adrenergic agents such as
epinephrine or pseudoepinephrine. Persons with liver, kidney, or
central nervous system diseases may be at increased risk from
exposure to this product. Alcoholic beverage consumption may enhance
the toxic effects of this substance. Effects may be delayed.
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion. Use water
spray to keep fire-exposed containers cool. Substance is
nonflammable. Vapors may be heavier than air. They can spread along
the ground and collect in low or confined areas. Containers may
explode when heated.
Extinguishing Media:
Use extinguishing media most appropriate for the surrounding fire.
Do NOT get water inside containers. Do NOT use straight streams of
water. For small fires, use dry chemical, carbon dioxide, or water
spray. For large fires, use water spray, fog or regular foam. Cool
containers with flooding quantities of water until well after fire
is out.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material, (e.g., dry sand or earth), then
place into a chemical waste container. Avoid runoff into storm
sewers and ditches which lead to waterways. Clean up spills
immediately, observing precautions in the Protective Equipment
section. Provide ventilation.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Use only in a well ventilated area. Avoid contact
with eyes, skin, and clothing. Do not breathe dust, vapor, mist, or
gas. Do not ingest or inhale. Store protected from light.
Storage:
Do not store in direct sunlight. Store in a cool, dry,
well-ventilated area away from incompatible substances. Keep away
from acids. Do not store near alkaline substances. Separate from
strong mineral acids.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate general or
local exhaust ventilation to keep airborne concentrations below the
permissible exposure limits.
Exposure Limits
+--------------------+-------------------+-------------------+-----------------+
| Chemical Name | ACGIH | NIOSH |OSHA - Final PELs|
|--------------------|-------------------|-------------------|-----------------|
| Chloroform |10 ppm |NIOSH Potential |C 50 ppm; C 240 |
| | |Occupational | mg/m3 |
| | | Carcinogen - see | |
| | |Appendix A | |
| | |Potential NIOSH | |
| | |carcinogen. | |
+--------------------+-------------------+-------------------+-----------------+
OSHA Vacated PELs:
Chloroform:
2 ppm TWA; 9.78 mg/m3 TWA
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR ??1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant a respirator's use.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Liquid
Appearance: clear, colorless
Odor: sweet, fruity odor - ethereal odor
pH: Not available.
Vapor Pressure: 160 mm Hg @ 20 deg C
Viscosity: 0.58 cps @ 20 d
Boiling Point: 60.5-61.5 deg C
Freezing/Melting Point: -63 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
NFPA Rating: (est.) Health: 2; Flammability: 0; Reactivity: 0
Explosion Limits, Lower: Not available.
Upper: Not available.
Decomposition Temperature: Not available.
Solubility: Slightly soluble.
Specific Gravity/Density: 1.492 (Water=1)
Molecular Formula: CHCl3
Molecular Weight: 119.366
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable at room temperature in closed containers under normal storage
and handling conditions. Light sensitive.
Conditions to Avoid:
High temperatures, incompatible materials, light.
Incompatibilities with Other Materials:
Strong oxidizing agents, aluminum, fluorine, magnesium, sodium
potassium, lithium, caustics (e.g. ammonia, ammonium hydroxide,
calcium hydroxide, potassium hydroxide, sodium hydroxide),
dinitrogen tetraoxide, sodium + methanol, potassium-tert-butoxide,
chemically active metals, Attacks some forms of plastics, rubbers,
and coatings., nitrogen tetroxide, acetone + alkali, disilane,
perchloric acid + phosphorus pentoxide, sodium methylate,
triisopropylphosphine, sodium methoxide + methanol.
Hazardous Decomposition Products:
Hydrogen chloride, irritating and toxic fumes and gases, carbon
dioxide, chlorine, phosgene gas.
Hazardous Polymerization: Will not occur.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 67-66-3: FS9100000
LD50/LC50:
CAS# 67-66-3: Inhalation, rat: LC50 =47702 mg/m3/4H; Oral, mouse:
LD50 = 36 mg/kg; Oral, rat: LD50 = 908 mg/kg; Skin, rabbit: LD50 =
>20 gm/kg.
Carcinogenicity:
Chloroform -
ACGIH: A3 - Animal Carcinogen
California: carcinogen; initial date 10/1/87
NIOSH: occupational carcinogen
NTP: Suspect carcinogen
OSHA: Possible Select carcinogen
IARC: Group 2B carcinogen
Epidemiology:
Oral, rat: TDLo = 13832 mg/kg/2Y-C (Tumorigenic - Carcinogenic by
RTECS criteria - Blood - leukemia).; Oral, mouse: TDLo = 127
gm/kg/92W-I (Tumorigenic - Carcinogenic by RTECS criteria - Liver -
tumors).; Oral, rat: TD = 98 gm/kg/78W-I (Tumorigenic - neoplastic
by RTECS criteria - Kidney, Ureter, Bladder - Kidney tumors and
Endocrine - thyroid tumors).; Oral, mouse: TD = 18 gm/kg/17W-I
(Tumorigenic - neoplastic by RTECS criteria - Liver - tumors).;
Teratogenicity:
Oral, rat: TDL0 = 1260 mg/kg (female 6-15 day(s) after conception)
Effects on Embryo or Fetus - fetotoxicity (except death, e.g.,
stunted fetus) Specific Developmental Abnormalities - musculoskeletal
system.; Inhalation, rat: TCLo = 100 ppm/7H (female 6-15 day(s) after
conception) Specific Developmental Abnormalities - gastrointestinal
system and homeostasis.; Inhalation, mouse: TCLo = 100 ppm/7H (female
8-15 day(s) after conception) Specific Developmental Abnormalities -
craniofacial (including nose and tongue).
Reproductive Effects:
Inhalation, rat: TCLo = 30 ppm/7H (female 6-15 day(s) after
conception) Fertility - other measures of fertility.; Inhalation,
rat: TCLo = 300 ppm/7H (female 6-15 day(s) after conception)
Fertility - female fertility index (e.g. # females pregnant per #
sperm positive females; # females pregnant per # females mated) and
post-implantation mortality (e.g. dead and/or resorbed implants per
total number of implants).
Neurotoxicity:
No information available.
Mutagenicity:
DNA Inhibition: Human, HeLa cell = 19 mmol/L.; Sister Chromatid
Exchange: Human, Lymphocyte = 10 mmol/L.; Micronucleus Test:
Oral,
rat = 4 mmol/kg.; Unscheduled DNA Synthesis: Oral, rat =
1 gm/kg.;
Sister Chromatid Exchange: Hamster, Embryo = 100 umol/L.
Other Studies:
Open irritation test: Administration onto the skin (rabbit) 10
mg/24H (Mild). Standard Draize Test: Administration onto the skin
(rabbit) = 500 mg/24H (Mild). Standard Draize Test: Administration
into the eye (rabbit) = 20 mg/24H (Moderate).
**** SECTION 12 - ECOLOGICAL INFORMATION ****
Ecotoxicity:
Fish: Channel catfish: LC50 = 75 ppm; 96 Hr; UnspecifiedFish: Rainbow
trout: LC50 = 43.8 mg/L; 96 Hr; Static bioassayFish: Fathead Minnow:
LC50 = 129.0 mg/L; 96 Hr; Static bioassay (pH = 7.6-8.3)Fish:
Bluegill/Sunfish: LC50 = 100.0 mg/L; 96 Hr; Static bioassayWater
flea Daphnia: EC50 = 28.9 mg/L; 48 Hr; Static bioassayThe majority of
the environmental releases from industrial uses are to the
atmosphere; releases to water and land will be primarily lost by
evaporation and will end up in the atmosphere. Release to the
atmosphere may be transported long distances and will photodegrade
with a half-life of a
few months. Spills and other releases on land
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Chemical waste generators must determine whether a discarded chemical is classif
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Part
Additionally, waste generators must consult state and local hazardous waste regu
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: CAS# 67-66-3: waste number U044.
**** SECTION 14 - TRANSPORT INFORMATION ****
CDG/CPL
Not classified as hazardous for supply.
Canadian TDG
Shipping Name: CHLOROFORM
Hazard Class: 6.1(9.2)
UN Number: UN1888
**** SECTION 15 - REGULATORY INFORMATION ****
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 22 Harmful if swallowed.
R 38 Irritating to skin.
R 40 Possible risks of irreversible effects.
R 48/20/22 Harmful : danger of serious damage to
health by prolonged exposure through inhalation and if
swallowed.
Safety Phrases:
S 36/37 Wear suitable protective clothing and
gloves.
WGK (Water Danger/Protection)
CAS# 67-66-3: 3
United Kingdom Occupational Exposure Limits
CAS# 67-66-3: OES-United Kingdom, TWA 2 ppm TWA; 9.9 mg/m3 TWA
Canada
CAS# 67-66-3 is listed on Canada's DSL/NDSL List.
This product has a WHMIS classification of D2A, D2B.
CAS# 67-66-3 is not listed on Canada's Ingredient Disclosure List.
Exposure Limits
CAS# 67-66-3: OEL-ARAB Republic of Egypt:TWA 10 ppm (50 mg/m3)
OEL-AUSTRALIA:TWA 10 ppm (50 mg/m3);Carcinogen
OEL-AUSTRIA:TWA 10 ppm (50 mg/m3)
OEL-BELGIUM:TWA 10 ppm (49 mg/m3);Carcinogen JAN9
OEL-CZECHOSLOVAKIA:TWA 10 mg/m3;STEL 20 mg/m3
OEL-DENMARK:TWA 2 ppm (10 mg/m3);Carcinogen
OEL-FINLAND:TWA 10 ppm (50 mg/m3);STEL 20 ppm;Skin;CAR
OEL-FRANCE:TWA 5 ppm (25 mg/m3);STEL 50 ppm (250 mg/m3);CAR
OEL-GERMANY:TWA 10 ppm (50 mg/m3);Carcinogen JAN9
OEL-HUNGARY:STEL 10 mg/m3
OEL-INDIA:TWA 10 ppm (50 mg/m3);Carcinogen
OEL-JAPAN:TWA 50 ppm (240 mg/m3);Carcinogen
OEL-THE NETHERLANDS:TWA 10 ppm (50 mg/m3)
OEL-THE PHILIPPINES:TWA 50 ppm (240 mg/m3)
OEL-POLAND:TWA 50 mg/m3
OEL-RUSSIA:TWA 50 ppm
OEL-SWEDEN:TWA 2 ppm (10 mg/m3);STEL 5 ppm (25 mg/m3);CAR
OEL-SWITZERLAND:TWA 10 ppm (50 mg/m3);STEL 20 ppm (100 mg/m3)
OEL-THAILAND:TWA 50 ppm (240 mg/m3)
OEL-TURKEY:TWA 50 ppm (240 mg/m3)
OEL-UNITED KINGDOM:TWA 10 ppm (50 mg/m3);STEL 50 ppm (225 mg/m3)
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV
US FEDERAL
TSCA
CAS# 67-66-3 is listed on the TSCA inventory.
Health & Safety Reporting List
CAS# 67-66-3: Effective Date: June 1, 1987; Sunset Date: June 1, 1997
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
SARA
Section 302 (RQ)
CAS# 67-66-3: final RQ = 10 pounds (4.54 kg)
Section 302 (TPQ)
CAS# 67-66-3: TPQ = 10,000 pounds; RQ = 10 pounds (does not meet
toxicity criteria but because of high production volume and
recognized toxicity is considered a chemical of concern)
SARA Codes
CAS # 67-66-3: acute, chronic.
Section 313
This material contains Chloroform (CAS# 67-66-3, 99%),which is
subject to the reporting requirements of Section 313 of SARA Title
III and 40 CFR Part 372.
Clean Air Act:
CAS# 67-66-3 is listed as a hazardous air pollutant (HAP).
This material does not contain any Class 1 Ozone depletors.
**** SECTION 16 - ADDITIONAL INFORMATION ****
MSDS Creation Date: 6/09/1999 Revision #5 Date: 8/02/2000
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
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