*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : VV7325000
CHEMICAL NAME : Silica, crystalline - cristobalite
CAS REGISTRY NUMBER : 14464-46-1
OTHER CAS REGISTRY NOS. : 1317-48-2
105269-70-3
LAST UPDATED : 199712
DATA ITEMS CITED : 38
MOLECULAR FORMULA : O2-Si
MOLECULAR WEIGHT : 60.09
WISWESSER LINE NOTATION : SI O2
COMPOUND DESCRIPTOR : Tumorigen
Human
SYNONYMS/TRADE NAMES :
* 43-63C
* Calcined diatomaceous earth
* Calcined diatomite
* Cristobalite
* alpha-Crystobalite
* Crysvarl
* Metacristobalite
* Silica, crystalline-cristobalite
* W 006
* WGL 300
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Human
DOSE/DURATION : 16 mppcf/8H/17.9Y-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
Lungs, Thorax, or Respiration - cough
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB246-697
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intratracheal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 200 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
REFERENCE :
BJIMAG British Journal of Industrial Medicine. (British Medical Journal,
Box 560B, Kennebunkport, ME 04046) V.1- 1944- Volume(issue)/page/year:
10,9,1953
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intrapleural
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 90 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60,
1940-78. For publisher information, see JJIND8. Volume(issue)/page/year:
57,509,1976
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intrapleural
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year:
41,908,1980
*** REVIEWS ***
ACGIH TLV-TWA 0.05 mg/m3, respirable dust
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 42,39,1987
IARC Cancer Revew:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 68,41,1997
IARC Cancer Review:Human Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 42,39,1987
IARC Cancer Revew:Human Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 68,41,1997
IARC Cancer Revew:Group 1
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 68,41,1997
TOXICOLOGY REVIEW
ANAEA3 Annals of Allergy. (American College of Allergists, POB 20671,
Bloomington, MN 55420) V.1- 1943- Volume(issue)/page/year: 35,165,1975
TOXICOLOGY REVIEW
31BYAP "Experimental Lung Cancer: Carcinogenesis and Bioassays,
International Symposium, 1974," Karbe, E., and J.F. Park, eds.,
Springer-Verlag New York, Inc., 1974 Volume(issue)/page/year: -,93,1974
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-respirable dust in air:TWA 10 mg/m3/2(% resp. SiO2+2)
DTLWS* "Documentation of the Threshold Limit Values for Substances in
Workroom Air," Supplements. For publisher information, see 85INA8.
Volume(issue)/page/year: 3,33,1973
MSHA STANDARD-total dust in air:TWA 30 mg/m3/2(% SiO2+3)
DTLWS* "Documentation of the Threshold Limit Values for Substances in
Workroom Air," Supplements. For publisher information, see 85INA8.
Volume(issue)/page/year: 3,33,1973
OSHA PEL (Gen Indu):8H TWA 5 mg/m3/(% resp SiO2+2)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 5 mg/m3/(% resp SiO2+2)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 20 mppcf/(%SiO2+5)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-BELGIUM:TWA 0.05 mg/m3 JAN 1993
OEL-DENMARK:TWA 0.05 mg/m3 JAN 1993
OEL-DENMARK:TWA 0.15 mg/m3 (total dust) JAN 1993
OEL-FINLAND:TWA 0.1 mg/m3 JAN 1993
OEL-GERMANY:TWA 0.15 mg/m3 JAN 1993
OEL-RUSSIA:STEL 1 mg/m3 (total dust) JAN 1993
OEL-SWEDEN:TWA 0.05 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 0.15 mg/m3 JAN 1993
OEL-THAILAND:TWA 10 mg/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.05 mg/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.15 mg/m3 (total dust) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO SILICA, cryst. cristobalite-air:10H CA TWA 0.05 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - T0624
No. of Facilities: 2072 (estimated)
No. of Industries: 33
No. of Occupations: 43
No. of Employees: 31369 (estimated)
No. of Female Employees: 2228 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH Analytical Method, 1994: Silica, crystalline, by XRD, 7500; by VIS,
7600; by IR, 7602
NTP 7th Annual Report on Carcinogens, 1992 : anticipated to be carcinogen
OSHA ANALYTICAL METHOD #ID-125G
*** END OF RECORD ***
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