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MSDS  : 2,2'-Stilbenedisulfonic acid, 4,4'-bis((4-anilino-6-morpholino-s-triazin-2-yl)amino )-, disodium salt
CAS  : 16090-02-1
SYNONYMS  : * Belotex KD * 4,4'-Bis((4-anilino-6-morpholino-1,3,5-triazine-2-yl)amino)stilbene 2,2-disulfonate 2Na * Blankophor BBH * Blankophor MBBH * Calcofluor White RC * C.I. Fluorescent Brightener 71 * C.I. Fluorescent Brightener 244 * C.I. Fluorescent Brightener 250 * C.I. Fluorescent Brightener 260 * Disodium 4,4'-bis((4-anilino-6-morpholino-1,3,5-triazin-2-yl)amino)stilbene-2,2'- disulfonate * FBA-260 * Heliofor 3BC * Heliofor BDC * Hiltamine Arctic White DML * Leukopur PAM * MBBH 766 * Mikephor TB * Phorwite MBBH 766 * Stralex MD * Tinopal AMS * Tinopal DMS-X * Tinopal EMS
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : WJ6147000
CHEMICAL NAME : 2,2'-Stilbenedisulfonic acid,
4,4'-bis((4-anilino-6-morpholino-s-triazin-2-yl)amino
)-, disodium salt
CAS REGISTRY NUMBER : 16090-02-1
OTHER CAS REGISTRY NOS. : 12646-20-7
LAST UPDATED : 199710
DATA ITEMS CITED : 17
MOLECULAR FORMULA : C40-H38-N12-O8-S2.2Na
MOLECULAR WEIGHT : 925.00
WISWESSER LINE NOTATION : T6N CN ENJ BMR& D- AT6N DOTJ& FMR CSWO D1U1R BSWO DM-
BT6N CN ENJ DMR& F- AT6N DOTJ &-NA- 2
COMPOUND DESCRIPTOR : Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Belotex KD
* 4,4'-Bis((4-anilino-6-morpholino-1,3,5-triazine-2-yl)amino)stilbene
2,2-disulfonate 2Na
* Blankophor BBH
* Blankophor MBBH
* Calcofluor White RC
* C.I. Fluorescent Brightener 71
* C.I. Fluorescent Brightener 244
* C.I. Fluorescent Brightener 250
* C.I. Fluorescent Brightener 260
* Disodium
4,4'-bis((4-anilino-6-morpholino-1,3,5-triazin-2-yl)amino)stilbene-2,2'-
disulfonate
* FBA-260
* Heliofor 3BC
* Heliofor BDC
* Hiltamine Arctic White DML
* Leukopur PAM
* MBBH 766
* Mikephor TB
* Phorwite MBBH 766
* Stralex MD
* Tinopal AMS
* Tinopal DMS-X
* Tinopal EMS

*** HEALTH HAZARD DATA ***

** SKIN/EYE IRRITATION DATA **

TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 100 mg
REACTION SEVERITY : Mild
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
27,494,1974

TYPE OF TEST : Rinsed with water
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 100 mg/2S
REACTION SEVERITY : Mild
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
27,494,1974

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CCECAU Criticial Reviews in Environmental Control. (Chemical Rubber
Company, Cleveland, OH) V.1- 1970- Volume(issue)/page/year: 7,91,1977

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd.
Russki 6, Sofia, Bulgaria) V.9- 1966- Volume(issue)/page/year:
29(2),24,1986

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >20 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SRTCAC Science Reports of the Research Institutes, Tohoku University, Series
C: Medicine. (Tohoku University, Research Institute for Tuberculosis and
Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949-
Volume(issue)/page/year: 36(1-4),10,1989

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : >500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CCECAU Criticial Reviews in Environmental Control. (Chemical Rubber
Company, Cleveland, OH) V.1- 1970- Volume(issue)/page/year: 7,91,1977

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CCECAU Criticial Reviews in Environmental Control. (Chemical Rubber
Company, Cleveland, OH) V.1- 1970- Volume(issue)/page/year: 7,91,1977

TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
27,494,1974

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CCECAU Criticial Reviews in Environmental Control. (Chemical Rubber
Company, Cleveland, OH) V.1- 1970- Volume(issue)/page/year: 7,91,1977

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 21 gm/kg/21D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in kidney weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd.
Russki 6, Sofia, Bulgaria) V.9- 1966- Volume(issue)/page/year:
29(2),24,1986

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M4765
No. of Facilities: 38 (estimated)
No. of Industries: 2
No. of Occupations: 3
No. of Employees: 759 (estimated)

NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M4765
No. of Facilities: 25 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 414 (estimated)
No. of Female Employees: 279 (estimated)

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal; In vitro
SCE-nonhuman

EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test

EPA GENETOX PROGRAM 1988, Inconclusive: S cerevisiae gene conversion

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998


*** END OF RECORD ***
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NAMECAS
Spiro(naphthalene-2(1H),2'-oxirane)-3'-carboxaldehyde, 3,5,6,7,8,8a-hexahydro-7-acetoxy-5,6-epoxy-3',8,8a-trimethyl-3-oxo- 56299-00-4
4,4'-Stilbenedicarboxamidine, 2-hydroxy- 495-99-8
4,4'-Stilbenedicarboxamidine, 2-hydroxy-,dihydrochloride 495-99-8
4,4'-Stilbenedicarboxamidine, 2-iodo-,dihydrochloride 495-99-8
4,4'-Stilbenedicarboxamidine, 2-methoxy-,dihydrochloride 495-99-8
4,4'-Stilbenedicarboxamidine, alpha-methyl-,dihydrochloride 495-99-8
4,4'-Stilbenedicarboxamidine, 2-methyl-,dihydrochloride 495-99-8
4,4'-Stilbenedicarboxamidine, sulfate, (Z)- 495-99-8
Stilbene, alpha,alpha'-diethyl-4,4'-dimethoxy- 7773-34-4
Stilbene, alpha,alpha'-diethyl-4,4'-dimethyl-, (E)- 34983-45-4
3,5-Stilbenediol, (E)- 22139-77-1
Spiro(naphthalene-2(1H),4'-piperidine),octahydro-1'-(3-phenothiazin-10-ylpropyl)-,hydrochloride 104269-03-6
4,4'-Stilbenediol,3,3'-bis(((2-(dimethylamino)ethyl)methylamino)methyl)-alpha,alpha'- diethyl-, (E)- 37013-44-8
3,3'-Stilbenediol,4,4'-bis((dimethylamino)methyl)-alpha,alpha'-diethyl-, (E)- 37013-48-2
4,4'-Stilbenediol,3,3'-bis((dimethylamino)methyl)-alpha,alpha'-diethyl-, (E)- 24524-66-1
2,2'-Stilbenediol, alpha,alpha'-diethyl-, (E)- 24524-66-1
3,3'-Stilbenediol, alpha,alpha'-diethyl-, (E)- 5959-71-7
4,4'-Stilbenediol, alpha,alpha'-diethyl- 56-53-1
4,4'-Stilbenediol, alpha,alpha'-diethyl-, (Z)- 22610-99-7
4,4'-Stilbenediol, alpha,alpha'-diethyl-,bis(bis(2-chloroethyl) sulfamate) 102584-76-9
4,4'-Stilbenediol, alpha,alpha'-diethyl-,bis(dihydrogen phosphate), (E)- 522-40-7
4,4'-Stilbenediol, alpha,alpha'-diethyl-,bis(dihydrogen phosphate), tetrasodium salt, (E)- 4719-75-9
Spiro(naphthalene-2(1H),4'-piperidinium),octahydro-1',1'-dimethyl-, iodide 106741-33-7
4,4'-Stilbenediol,alpha,alpha'-diethyl-3-((dimethylamino)methyl)-, (E)- 37013-41-5
4,4'-Stilbenediol, alpha,alpha'-diethyl-, dipalmitate 63019-08-9
4,4'-Stilbenediol, alpha,alpha'-diethyl-,dipropionate, (E)- 130-80-3
4,4'-Stilbenediol, alpha,alpha'-diethyl-, disodiumsalt 63528-82-5
4,4'-Stilbenediol,alpha,alpha'-diethyl-3,3',5,5'-tetrafluoro-, (E)- 71292-84-7
4,4'-Stilbenediol,alpha,alpha'-diethyl-3,3',5,5'-tetramethyl- 4503-78-0
4,4'-Stilbenediol, alpha,alpha'-dimethyl-, (E)- 552-80-7
4,4'-Stilbenediol, alpha,alpha'-dimethyl-, diacetate(ester), (E)- 70244-12-1
4,4'-Stilbenediol, alpha,alpha'-dimethyl-, diacetate,(Z)- 102584-77-0
4,4'-Stilbenediol, alpha,alpha'-dimethyl-,dipropionate, (E)- 71543-58-3
Spiro(naphthalene-1(2H),3'-pyrrole)-2',5'-dione,1',3,4,4'-tetrahydro-1'-(3-(diethylamino) propyl)-,monohydrochloride 17592-97-1
4,4'-Stilbenediol, alpha-ethyl- 3691-71-2
2,2'-Stilbenediol, 5-hexyl- (E)- 18221-53-9
4,4'-Stilbenediol, alpha-methyl-alpha'-propyl- 4050-86-6
4,4'-Stilbenediol,alpha-phenyl-3,3',5,5'-tetramethyl- 4050-86-6
4,4'-Stilbenediol, alpha-propyl- 93651-83-3
4,4'-Stilbenediol, tetraiodo-alpha,alpha'-diethyl- 64043-55-6
2,2'-Stilbenedisulfonic acid,4-(4-amino-6-anilino-s-triazin-2-yl)-4'-(4-((4-acetamido-2-sulfophenylcarbamoylphenylcarbamoylanilino)-6-amino-s-triazin-2-yl)amino)-, disodium salt 64043-55-6
2,2'-Stilbenedisulfonic acid, 4-amino-4'-nitro- 119-72-2
2,2'-Stilbenedisulfonic acid,4,4'-bis((4-amino-6-(2-hydroxyethyl)amino-s-triazin-2-yl) amino)-, disodium salt 25295-51-6
2,2'-Stilbenedisulfonic acid,4,4'-bis((4-anilino-6-bis(2-hydroxyethyl)amino-s-triazin-2-yl) amino)-, disodium salt 4193-55-9
Spiro(naphthalene-2(1H),3'-pyrrolidine)-2',5'-dione,3,4-dihydro- 98054-83-2
2,2'-Stilbenedisulfonic acid,4,4'-bis((4-anilino-6-((2-hydroxyethyl)amino)-s-triazin-2-yl) amino)-, disodium salt 17958-73-5
2,2'-Stilbenedisulfonic acid,4,4'-bis((4-anilino-6-((2-hydroxyethyl)methylamino)-s-triazin- 2-yl)amino)-, disodium salt 13863-31-5
2,2'-Stilbenedisulfonic acid,4,4'-bis((4-anilino-6-methoxy-s-triazin-2-yl)amino)-,disodium salt 3426-43-5
2,2'-Stilbenedisulfonic acid,4,4'-bis((4-anilino-6-methylamino-s-triazin-2-yl)amino)-, disodium salt 31900-04-6
2,2'-Stilbenedisulfonic acid,4,4'-bis((4-anilino-6-morpholino-s-triazin-2-yl)amino)-, disodium salt 16090-02-1

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