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MSDS  : Spiro(naphthalene-2(1H),2'-oxirane)-3'-carboxaldehyde , 3,5,6,7,8,8a-hexahydro-7-acetoxy-5,6- epoxy-3',8,8a-trimethyl-3-oxo-
CAS  : 56299-00-4
SYNONYMS  : * PRT * PR toxin * PR toxine * Toxin (Penicillium roquefortii) * Toxin PR
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : WH1318000
CHEMICAL NAME : Spiro(naphthalene-2(1H),2'-oxirane)-3'-carboxaldehyde
, 3,5,6,7,8,8a-hexahydro-7-acetoxy-5,6-
epoxy-3',8,8a-trimethyl-3-oxo-
CAS REGISTRY NUMBER : 56299-00-4
LAST UPDATED : 199410
DATA ITEMS CITED : 21
MOLECULAR FORMULA : C17-H20-O6
MOLECULAR WEIGHT : 320.37
WISWESSER LINE NOTATION : T B366 CO JV KUTJ EOV1 F1 G1 IOV1
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Natural Product
SYNONYMS/TRADE NAMES :
* PRT
* PR toxin
* PR toxine
* Toxin (Penicillium roquefortii)
* Toxin PR

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 115 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - other changes
REFERENCE :
APMBAY Applied Microbiology. (Washington, DC) V.1-30, 1953-75. For
publisher information, see AEMIDF. Volume(issue)/page/year: 25,111,1973

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 11600 ug/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Behavioral - muscle weakness
Behavioral - ataxia
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
UK) V.1- 1962- Volume(issue)/page/year: 20,433,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 8200 ug/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Behavioral - muscle weakness
Behavioral - ataxia
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
UK) V.1- 1962- Volume(issue)/page/year: 20,433,1982

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 72 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal)
Behavioral - fluid intake
Behavioral - changes in motor activity (specific assay)
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,369,1978

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal)
Behavioral - fluid intake
Behavioral - changes in motor activity (specific assay)
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,369,1978

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca
Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 6,116,1981

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 100 mg/kg/52D-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
MYCPAH Mycopathologia. (Kluwer Academic Pub. Group, Distribution Centre,
POB 322, 3300 AH Dordrecht, Netherlands) V.1- 1938-
Volume(issue)/page/year: 78,125,1982

TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 139 mg/kg/52D-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Reproductive - Tumorigenic effects - uterine tumors
REFERENCE :
MYCPAH Mycopathologia. (Kluwer Academic Pub. Group, Distribution Centre,
POB 322, 3300 AH Dordrecht, Netherlands) V.1- 1938-
Volume(issue)/page/year: 78,125,1982

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 625 ng/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 130,79,1984

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 100 ug/plate
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
38,536,1978

TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Bacillus subtilis
DOSE/DURATION : 100 ug/disc
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
36,445,1976

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Mold - Neurospora crassa
DOSE/DURATION : 2 mg/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 1,45,1979

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 30 mg/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 1,45,1979

TYPE OF TEST : Gene conversion and mitotic recombination
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 5 mg/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 1,45,1979

TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 25 umol/L
REFERENCE :
TOERD9 Toxicological European Research. (S.P.E., 10, Ave. de Messine, 75008
Paris, France) V.1- 1978- Volume(issue)/page/year: 2,273,1979

TYPE OF TEST : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 10 mg/kg
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
14,207,1976

TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 35 mg/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
18,153,1977

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Positive: N crassa-reversion; B subtilis rec assay

EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis; S
cerevisiae-reversion

EPA GENETOX PROGRAM 1988, Weakly Positive: S cerevisiae gene conversion

EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
Spiro(naphthalene-2(1H),2'-oxirane)-3'-carboxaldehyde, 3,5,6,7,8,8a-hexahydro-7-acetoxy-5,6-epoxy-3',8,8a-trimethyl-3-oxo- 56299-00-4
4,4'-Stilbenedicarboxamidine, 2-hydroxy- 495-99-8
4,4'-Stilbenedicarboxamidine, 2-hydroxy-,dihydrochloride 495-99-8
4,4'-Stilbenedicarboxamidine, 2-iodo-,dihydrochloride 495-99-8
4,4'-Stilbenedicarboxamidine, 2-methoxy-,dihydrochloride 495-99-8
4,4'-Stilbenedicarboxamidine, alpha-methyl-,dihydrochloride 495-99-8
4,4'-Stilbenedicarboxamidine, 2-methyl-,dihydrochloride 495-99-8
4,4'-Stilbenedicarboxamidine, sulfate, (Z)- 495-99-8
Stilbene, alpha,alpha'-diethyl-4,4'-dimethoxy- 7773-34-4
Stilbene, alpha,alpha'-diethyl-4,4'-dimethyl-, (E)- 34983-45-4
3,5-Stilbenediol, (E)- 22139-77-1
Spiro(naphthalene-2(1H),4'-piperidine),octahydro-1'-(3-phenothiazin-10-ylpropyl)-,hydrochloride 104269-03-6
4,4'-Stilbenediol,3,3'-bis(((2-(dimethylamino)ethyl)methylamino)methyl)-alpha,alpha'- diethyl-, (E)- 37013-44-8
3,3'-Stilbenediol,4,4'-bis((dimethylamino)methyl)-alpha,alpha'-diethyl-, (E)- 37013-48-2
4,4'-Stilbenediol,3,3'-bis((dimethylamino)methyl)-alpha,alpha'-diethyl-, (E)- 24524-66-1
2,2'-Stilbenediol, alpha,alpha'-diethyl-, (E)- 24524-66-1
3,3'-Stilbenediol, alpha,alpha'-diethyl-, (E)- 5959-71-7
4,4'-Stilbenediol, alpha,alpha'-diethyl- 56-53-1
4,4'-Stilbenediol, alpha,alpha'-diethyl-, (Z)- 22610-99-7
4,4'-Stilbenediol, alpha,alpha'-diethyl-,bis(bis(2-chloroethyl) sulfamate) 102584-76-9
4,4'-Stilbenediol, alpha,alpha'-diethyl-,bis(dihydrogen phosphate), (E)- 522-40-7
4,4'-Stilbenediol, alpha,alpha'-diethyl-,bis(dihydrogen phosphate), tetrasodium salt, (E)- 4719-75-9
Spiro(naphthalene-2(1H),4'-piperidinium),octahydro-1',1'-dimethyl-, iodide 106741-33-7
4,4'-Stilbenediol,alpha,alpha'-diethyl-3-((dimethylamino)methyl)-, (E)- 37013-41-5
4,4'-Stilbenediol, alpha,alpha'-diethyl-, dipalmitate 63019-08-9
4,4'-Stilbenediol, alpha,alpha'-diethyl-,dipropionate, (E)- 130-80-3
4,4'-Stilbenediol, alpha,alpha'-diethyl-, disodiumsalt 63528-82-5
4,4'-Stilbenediol,alpha,alpha'-diethyl-3,3',5,5'-tetrafluoro-, (E)- 71292-84-7
4,4'-Stilbenediol,alpha,alpha'-diethyl-3,3',5,5'-tetramethyl- 4503-78-0
4,4'-Stilbenediol, alpha,alpha'-dimethyl-, (E)- 552-80-7
4,4'-Stilbenediol, alpha,alpha'-dimethyl-, diacetate(ester), (E)- 70244-12-1
4,4'-Stilbenediol, alpha,alpha'-dimethyl-, diacetate,(Z)- 102584-77-0
4,4'-Stilbenediol, alpha,alpha'-dimethyl-,dipropionate, (E)- 71543-58-3
Spiro(naphthalene-1(2H),3'-pyrrole)-2',5'-dione,1',3,4,4'-tetrahydro-1'-(3-(diethylamino) propyl)-,monohydrochloride 17592-97-1
4,4'-Stilbenediol, alpha-ethyl- 3691-71-2
2,2'-Stilbenediol, 5-hexyl- (E)- 18221-53-9
4,4'-Stilbenediol, alpha-methyl-alpha'-propyl- 4050-86-6
4,4'-Stilbenediol,alpha-phenyl-3,3',5,5'-tetramethyl- 4050-86-6
4,4'-Stilbenediol, alpha-propyl- 93651-83-3
4,4'-Stilbenediol, tetraiodo-alpha,alpha'-diethyl- 64043-55-6
2,2'-Stilbenedisulfonic acid,4-(4-amino-6-anilino-s-triazin-2-yl)-4'-(4-((4-acetamido-2-sulfophenylcarbamoylphenylcarbamoylanilino)-6-amino-s-triazin-2-yl)amino)-, disodium salt 64043-55-6
2,2'-Stilbenedisulfonic acid, 4-amino-4'-nitro- 119-72-2
2,2'-Stilbenedisulfonic acid,4,4'-bis((4-amino-6-(2-hydroxyethyl)amino-s-triazin-2-yl) amino)-, disodium salt 25295-51-6
2,2'-Stilbenedisulfonic acid,4,4'-bis((4-anilino-6-bis(2-hydroxyethyl)amino-s-triazin-2-yl) amino)-, disodium salt 4193-55-9
Spiro(naphthalene-2(1H),3'-pyrrolidine)-2',5'-dione,3,4-dihydro- 98054-83-2
2,2'-Stilbenedisulfonic acid,4,4'-bis((4-anilino-6-((2-hydroxyethyl)amino)-s-triazin-2-yl) amino)-, disodium salt 17958-73-5
2,2'-Stilbenedisulfonic acid,4,4'-bis((4-anilino-6-((2-hydroxyethyl)methylamino)-s-triazin- 2-yl)amino)-, disodium salt 13863-31-5
2,2'-Stilbenedisulfonic acid,4,4'-bis((4-anilino-6-methoxy-s-triazin-2-yl)amino)-,disodium salt 3426-43-5
2,2'-Stilbenedisulfonic acid,4,4'-bis((4-anilino-6-methylamino-s-triazin-2-yl)amino)-, disodium salt 31900-04-6
2,2'-Stilbenedisulfonic acid,4,4'-bis((4-anilino-6-morpholino-s-triazin-2-yl)amino)-, disodium salt 16090-02-1

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