*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : WZ1225000
CHEMICAL NAME : Terephthalic acid, dimethyl ester
CAS REGISTRY NUMBER : 120-61-6
LAST UPDATED : 199710
DATA ITEMS CITED : 17
MOLECULAR FORMULA : C10-H10-O4
MOLECULAR WEIGHT : 194.20
WISWESSER LINE NOTATION : 1OVR DVO1
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* 1,4-Benzenedicarboxylic acid, dimethyl ester
* Dimethyl 1,4-benzenedicarboxylate
* Dimethylester kyseliny tereftalove
* Dimethyl p-phthalate
* Di-Me terephthalate
* Dimethyl terephthalate
* DMT
* Methyl 4-carbomethoxybenzoate
* Methyl p-(methoxycarbonyl)benzoate
* NCI-C50055
* Terephthalic acid methyl ester
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/24H
REACTION SEVERITY : Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,386,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >3200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
14CYAT "Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed., New
York, John Wiley & Sons, Inc., 1958-63 Volume(issue)/page/year: 2,1906,1963
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3900 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:
34,455,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
14CYAT "Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed., New
York, John Wiley & Sons, Inc., 1958-63 Volume(issue)/page/year: 2,1906,1963
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 57600 mg/kg/14W-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:
34,455,1973
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1 mg/m3/2H/22W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Vascular - BP lowering not characterized in autonomic section
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
Toxicology of New Industrial Chemical Substances. For English translation,
see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
Volume(issue)/page/year: 5,107,1963
** MUTATION DATA **
TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 200 umol/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 204,703,1988
*** REVIEWS ***
TOXICOLOGY REVIEW
BPCT** Progress Report from the Environmental Protection Agency to NIOSH on
Benzenepolycarboxylates, 1974 Volume(issue)/page/year: -,183,1974
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 0.1 mg/m3 JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83502
No. of Facilities: 58 (estimated)
No. of Industries: 5
No. of Occupations: 7
No. of Employees: 993 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83502
No. of Facilities: 104 (estimated)
No. of Industries: 3
No. of Occupations: 3
No. of Employees: 2467 (estimated)
No. of Female Employees: 204 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat; Cell
transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NCI Carcinogenesis Bioassay (feed);equivocal evidence:mouse
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-121,79
NCI Carcinogenesis Bioassay (feed);no evidence:rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-121,79
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
Terephthalamide,N,N'-bis(1-methyl-4-piperidylmethyl)-, hemihydrate
| 10593-60-9 |
Terephthalamide, N,N'-bis(4-piperidylmethyl)-,hydrate
| 15234-94-3 |
Terephthalamide, N,N'-dimethyl-N,N'-dinitroso-
| 133-55-1 |
Terephthalamidine,N,N''-bis(p-(methylamidino)phenyl)-,tetrahydrochloride
| 2053-23-8 |
Sulfuric acid, zinc salt, basic
| 68813-94-5 |
Terephthalanilide,2-amino-4',4''-bis(N-methylamidino)-,trihydrochloride
| 68813-94-5 |
Terephthalanilide,2-amino-4',4''-bis(5-methyl-2-imidazolin-2-yl)-
| 4607-27-6 |
Terephthalanilide,4',4''-bis(2-imidazolin-2-ylamino)-
| 537-66-6 |
Terephthalanilide,4',4''-bis(2-imidazolin-2-yl)-2-chloro-
| 1820-92-4 |
Terephthalic acid
| 100-21-0 |
Terephthalic acid, compd. with3-(2-aminoethyl)indol-5-ol and acetate (1:2:2)
| 52671-02-0 |
Terephthalic acid, bis(3-dibutylaminopropyl) ester,hydrochloride
| 52671-02-0 |
Terephthalic acid, bis(2-diethylaminoethyl) ester,hydrochloride
| 52671-02-0 |
Terephthalic acid, bis(2-dimethylaminoethyl) ester,hydrochloride
| 52671-02-0 |
Terephthalic acid, bis(2-ethylhexyl) ester
| 6422-86-2 |
Sulfurous acid
| 7782-99-2 |
Terephthalic acid,bis(1-methyl-4-phenyl-4-piperidylmethyl) ester,dihydrochloride, hydrate
| 102339-08-2 |
Terephthalic acid, dibutyl ester
| 1962-75-0 |
Terephthalic acid, dicyclopentyl ester
| 18699-50-8 |
Terephthalic acid, didodecyl ester
| 18749-84-3 |
Terephthalic acid, diester with2-methyl-1-piperidinepropanol, hydrochloride
| 18749-84-3 |
Terephthalic acid, diethyl ester
| 636-09-9 |
Terephthalic acid, diisobutyl ester
| 18699-48-4 |
Terephthalic acid, diisopropyl ester
| 6422-84-0 |
Terephthalic acid, dimethyl ester
| 120-61-6 |
Terephthalic acid, dipentyl ester
| 1818-95-7 |
Sulfurous acid, bis(alpha-methylphenethyl) ester
| 74039-47-7 |
Terephthalic acid, dipropyl ester
| 1962-74-9 |
Terephthalic acid, disodium salt
| 10028-70-3 |
Terephthalic acid, 1,4-dithio-
| 1076-98-8 |
Terephthalic acid, 1,4-dithio-,S,S-bis(2,3-epithiopropyl) ester
| 1076-98-8 |
Terephthalic acid, compd. with dodecylguanidine (12)
| 19727-17-4 |
Terephthalic acid, tetrachloro-, dimethyl ester
| 1861-32-1 |
Terephthalic acid, 2,3,5,6-tetraiodo-,bis(2,3-dihydroxypropyl) ester
| 61838-99-1 |
Terephthalic acid, 2,3,5,6-tetraiodo-,bis(2-hydroxyethyl) ester
| 61838-98-0 |
Terephthalic acid, 2,3,5,6-tetraiodo-, dimethyl ester
| 61839-06-3 |
Terephthalohydroxamic acid
| 20073-80-7 |
Sulfurous acid, bis(2-propynyl) ester
| 1899-25-8 |
Terephthaloyl chloride
| 100-20-9 |
Tergitol anionic P-28
| 141-65-1 |
Tergitol 12-M-10 (nonionic)
| 12627-30-4 |
Tergitol minfoam
| 12627-30-4 |
Tergitol min-foam 1X
| 103331-86-8 |
Tergitol min-foam 2X
| 103331-86-8 |
Tergitol NP-14
| 9016-45-9 |
Tergitol NP-27
| 9016-45-9 |
Tergitol NP-33 (nonionic)
| 9016-45-9 |
Tergitol NP-35 (nonionic)
| 9016-45-9 |
Sulfurous acid, butyl 4-chloro-2-butynyl ester
| 74039-48-8 |
Tergitol NP-40 (nonionic)
| 9016-45-9 |
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