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MSDS  : Terephthalic acid, dimethyl ester
CAS  : 120-61-6
SYNONYMS  : * 1,4-Benzenedicarboxylic acid, dimethyl ester * Dimethyl 1,4-benzenedicarboxylate * Dimethylester kyseliny tereftalove * Dimethyl p-phthalate * Di-Me terephthalate * Dimethyl terephthalate * DMT * Methyl 4-carbomethoxybenzoate * Methyl p-(methoxycarbonyl)benzoate * NCI-C50055 * Terephthalic acid methyl ester
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : WZ1225000
CHEMICAL NAME : Terephthalic acid, dimethyl ester
CAS REGISTRY NUMBER : 120-61-6
LAST UPDATED : 199710
DATA ITEMS CITED : 17
MOLECULAR FORMULA : C10-H10-O4
MOLECULAR WEIGHT : 194.20
WISWESSER LINE NOTATION : 1OVR DVO1
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* 1,4-Benzenedicarboxylic acid, dimethyl ester
* Dimethyl 1,4-benzenedicarboxylate
* Dimethylester kyseliny tereftalove
* Dimethyl p-phthalate
* Di-Me terephthalate
* Dimethyl terephthalate
* DMT
* Methyl 4-carbomethoxybenzoate
* Methyl p-(methoxycarbonyl)benzoate
* NCI-C50055
* Terephthalic acid methyl ester

*** HEALTH HAZARD DATA ***

** SKIN/EYE IRRITATION DATA **

TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/24H
REACTION SEVERITY : Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,386,1986

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >3200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
14CYAT "Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed., New
York, John Wiley & Sons, Inc., 1958-63 Volume(issue)/page/year: 2,1906,1963

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3900 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:
34,455,1973

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
14CYAT "Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed., New
York, John Wiley & Sons, Inc., 1958-63 Volume(issue)/page/year: 2,1906,1963

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 57600 mg/kg/14W-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:
34,455,1973

TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1 mg/m3/2H/22W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Vascular - BP lowering not characterized in autonomic section
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
Toxicology of New Industrial Chemical Substances. For English translation,
see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
Volume(issue)/page/year: 5,107,1963

** MUTATION DATA **

TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 200 umol/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 204,703,1988

*** REVIEWS ***

TOXICOLOGY REVIEW
BPCT** Progress Report from the Environmental Protection Agency to NIOSH on
Benzenepolycarboxylates, 1974 Volume(issue)/page/year: -,183,1974

*** OCCUPATIONAL EXPOSURE LIMITS ***

OEL-RUSSIA:STEL 0.1 mg/m3 JAN 1993

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83502
No. of Facilities: 58 (estimated)
No. of Industries: 5
No. of Occupations: 7
No. of Employees: 993 (estimated)

NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83502
No. of Facilities: 104 (estimated)
No. of Industries: 3
No. of Occupations: 3
No. of Employees: 2467 (estimated)
No. of Female Employees: 204 (estimated)

*** STATUS IN U.S. ***

EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat; Cell
transform.-SA7/SHE

EPA TSCA Section 8(b) CHEMICAL INVENTORY

On EPA IRIS database

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

NCI Carcinogenesis Bioassay (feed);equivocal evidence:mouse
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-121,79

NCI Carcinogenesis Bioassay (feed);no evidence:rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-121,79


*** END OF RECORD ***
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NAMECAS
Terephthalamide,N,N'-bis(1-methyl-4-piperidylmethyl)-, hemihydrate 10593-60-9
Terephthalamide, N,N'-bis(4-piperidylmethyl)-,hydrate 15234-94-3
Terephthalamide, N,N'-dimethyl-N,N'-dinitroso- 133-55-1
Terephthalamidine,N,N''-bis(p-(methylamidino)phenyl)-,tetrahydrochloride 2053-23-8
Sulfuric acid, zinc salt, basic 68813-94-5
Terephthalanilide,2-amino-4',4''-bis(N-methylamidino)-,trihydrochloride 68813-94-5
Terephthalanilide,2-amino-4',4''-bis(5-methyl-2-imidazolin-2-yl)- 4607-27-6
Terephthalanilide,4',4''-bis(2-imidazolin-2-ylamino)- 537-66-6
Terephthalanilide,4',4''-bis(2-imidazolin-2-yl)-2-chloro- 1820-92-4
Terephthalic acid 100-21-0
Terephthalic acid, compd. with3-(2-aminoethyl)indol-5-ol and acetate (1:2:2) 52671-02-0
Terephthalic acid, bis(3-dibutylaminopropyl) ester,hydrochloride 52671-02-0
Terephthalic acid, bis(2-diethylaminoethyl) ester,hydrochloride 52671-02-0
Terephthalic acid, bis(2-dimethylaminoethyl) ester,hydrochloride 52671-02-0
Terephthalic acid, bis(2-ethylhexyl) ester 6422-86-2
Sulfurous acid 7782-99-2
Terephthalic acid,bis(1-methyl-4-phenyl-4-piperidylmethyl) ester,dihydrochloride, hydrate 102339-08-2
Terephthalic acid, dibutyl ester 1962-75-0
Terephthalic acid, dicyclopentyl ester 18699-50-8
Terephthalic acid, didodecyl ester 18749-84-3
Terephthalic acid, diester with2-methyl-1-piperidinepropanol, hydrochloride 18749-84-3
Terephthalic acid, diethyl ester 636-09-9
Terephthalic acid, diisobutyl ester 18699-48-4
Terephthalic acid, diisopropyl ester 6422-84-0
Terephthalic acid, dimethyl ester 120-61-6
Terephthalic acid, dipentyl ester 1818-95-7
Sulfurous acid, bis(alpha-methylphenethyl) ester 74039-47-7
Terephthalic acid, dipropyl ester 1962-74-9
Terephthalic acid, disodium salt 10028-70-3
Terephthalic acid, 1,4-dithio- 1076-98-8
Terephthalic acid, 1,4-dithio-,S,S-bis(2,3-epithiopropyl) ester 1076-98-8
Terephthalic acid, compd. with dodecylguanidine (12) 19727-17-4
Terephthalic acid, tetrachloro-, dimethyl ester 1861-32-1
Terephthalic acid, 2,3,5,6-tetraiodo-,bis(2,3-dihydroxypropyl) ester 61838-99-1
Terephthalic acid, 2,3,5,6-tetraiodo-,bis(2-hydroxyethyl) ester 61838-98-0
Terephthalic acid, 2,3,5,6-tetraiodo-, dimethyl ester 61839-06-3
Terephthalohydroxamic acid 20073-80-7
Sulfurous acid, bis(2-propynyl) ester 1899-25-8
Terephthaloyl chloride 100-20-9
Tergitol anionic P-28 141-65-1
Tergitol 12-M-10 (nonionic) 12627-30-4
Tergitol minfoam 12627-30-4
Tergitol min-foam 1X 103331-86-8
Tergitol min-foam 2X 103331-86-8
Tergitol NP-14 9016-45-9
Tergitol NP-27 9016-45-9
Tergitol NP-33 (nonionic) 9016-45-9
Tergitol NP-35 (nonionic) 9016-45-9
Sulfurous acid, butyl 4-chloro-2-butynyl ester 74039-48-8
Tergitol NP-40 (nonionic) 9016-45-9

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