*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : YU8050000
CHEMICAL NAME : Uridine, 5-fluoro-
CAS REGISTRY NUMBER : 316-46-1
BEILSTEIN REFERENCE NO. : 0033662
REFERENCE : 4-24-00-01231 (Beilstein Handbook Reference)
LAST UPDATED : 199612
DATA ITEMS CITED : 10
MOLECULAR FORMULA : C9-H11-F-N2-O6
MOLECULAR WEIGHT : 262.22
WISWESSER LINE NOTATION : T6NVMVJ EF A- ET5OTJ B1Q CQ DQ
COMPOUND DESCRIPTOR : Drug
Mutagen
SYNONYMS/TRADE NAMES :
* 5-Fluorouridine
* Fur
* 5-Fur
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72.
Discontinued. Volume(issue)/page/year: 3,181,1968
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 160 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
39,2406,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 384 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 97,470,1958
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 250 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 97,470,1958
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 20 mg/L
REFERENCE :
VIRLAX Virology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
V.1- 1955- Volume(issue)/page/year: 74,154,1976
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Human HeLa cell
DOSE/DURATION : 10 umol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year:
14,205,1965
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 10 ug/L
REFERENCE :
HEREAY Hereditas (Lund, Sweden). (Gjoerloffsgatan 121, S-261 34 Landskrona,
Sweden) V.1- 1947- Volume(issue)/page/year: 88,127,1978
TYPE OF TEST : DNA inhibition
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 500 umol/kg
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
39,2406,1979
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Rodent - mouse Leukocyte
DOSE/DURATION : 900 nmol/L
REFERENCE :
CCCCAK Collection of Czechoslovak Chemical Communications. (Academic Press
Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1929-
Volume(issue)/page/year: 49,2551,1984
*** REVIEWS ***
TOXICOLOGY REVIEW
32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York,
Springer, 1975 Volume(issue)/page/year: -,49,1975
*** END OF RECORD ***
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| ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| | NAME | CAS |
|
Uridine, 2'-deoxy-, 5'-(dihydrogen phosphate)
| 964-26-1 |
|
Urea, 1,1-dimethyl-
| 598-94-7 |
|
Uridine, 2'-deoxy-5-ethyl-
| 15176-29-1 |
|
Uridine, 2'-deoxy-5-ethynyl-
| 61135-33-9 |
|
Uridine, 2'-deoxy-5-fluoro-
| 50-91-9 |
|
Uridine, 5'-deoxy-5-fluoro-
| 3094-09-5 |
|
Uridine, 2'-deoxy-5-fluoro-3'-O-(phenylmethyl)-
| 95969-44-1 |
|
Uridine, 2'-deoxy-5-fluoro-3'-O-(phenylmethyl)-,5'-acetate
| 103766-68-3 |
|
Uridine, 2'-deoxy-5-(hydroxymethyl)-
| 5116-24-5 |
|
Uridine, 2'-deoxy-5-iodo-
| 54-42-2 |
|
Uridine, 2'-deoxy-5-(2-iodovinyl)-, (E)-
| 69304-48-9 |
|
Uridine, 2'-deoxy-5-mercapto-
| 7085-54-3 |
|
Urea, 1,3-dimethyl-
| 96-31-1 |
|
Uridine, 2'-deoxy-5-methoxymethyl-
| 5116-22-3 |
|
Uridine, 2'-deoxy-5-nitro-, 5'-dihydrogen phosphate
| 5116-22-3 |
|
Uridine, 2'-deoxy-5-(1-propenyl)-, (E)-
| 66270-29-9 |
|
Uridine, 2'-deoxy-5-(3,3,3-trifluoro-1-propenyl)-,(E)-
| 69819-96-1 |
|
Uridine, 2'-deoxy-5-vinyl-
| 55520-67-7 |
|
Uridine, 5'-dihydrogen phosphate, disodium salt
| 3387-36-8 |
|
Uridine, 5-fluoro-
| 316-46-1 |
|
Uridine, 5-fluoro-2',3'-O-(1-methylethylidene)-
| 2797-17-3 |
|
Uridine, 5-((formyloxy)methyl)-
| 129051-71-4 |
|
Uridine, 4-hydrazone
| 57294-74-3 |
|
Urea, 1-(N,N-dimethylalanyl)-3-(p-ethoxyphenyl)-
| 4046-47-3 |
|
Uridine, 4-oxime
| 3258-02-4 |
|
Uridine, 5'-(tetrahydrogen triphosphate)
| 63-39-8 |
|
5'-Uridylic acid
| 58-97-9 |
|
5'-Uridylic acid, sodium salt
| 7545-48-4 |
|
UrocalumSUBSTANCE DEFINITION :Extracted from C. salicina Oerst.REFERENCE :NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,Japan) Volume(issue)/page/year: 6,96,1982
| 7545-48-4 |
|
Urokrein
| 7545-48-4 |
|
Ursa-9(11),12-diene-3,28-diol, bis(hydrogen1,2-benzendicarboxylate), disodium salt, (3-beta)-
| 146029-91-6 |
|
Urs-12-ene-23,28-dioic acid, 2,3-bis(acetyloxy)-,(2-alpha,3-beta,4-beta,20-beta)-
| 79679-46-2 |
|
Urs-12-ene-27,28-dioic acid, 3-beta-hydroxy-
| 465-74-7 |
|
Urs-12-en-28-oic acid, 3-beta-hydroxy-,2-(dimethylamino)ethyl ester, hydrochloride
| 465-74-7 |
|
|