*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : DE9100000
CHEMICAL NAME : 1H-1,4-Benzodiazepine,
7-chloro-2,3-dihydro-1-methyl-5-phenyl-,
monohydrochloride
CAS REGISTRY NUMBER : 2898-11-5
LAST UPDATED : 199706
DATA ITEMS CITED : 12
MOLECULAR FORMULA : C16-H15-Cl-N2.Cl-H
MOLECULAR WEIGHT : 307.24
WISWESSER LINE NOTATION : T67 GN JN JU&TJ CG G1 KR &GH
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Ansius
* 7-Chlor-2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepin hydrochlorid
* 7-Chloro-2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepine,
hydrochloride
* Diepin
* Elbrus
* Esmail
* Medazepam hydrochloride
* Medazepol
* Megasedan
* Mezepan
* RB 252
* Ro 5-4556
* S-804
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
18,185,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 210 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 18,1542,1968
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1700 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 18,1542,1968
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 91 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 4,833,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 710 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 18,1542,1968
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 314 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 4,833,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 720 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 18,1542,1968
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 47 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 4,833,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 530 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 18,1542,1968
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 15 gm/kg/30D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Related to Chronic Data - death
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 4,833,1970
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 31200 mg/kg/26W-I
TOXIC EFFECTS :
Cardiac - changes in heart weight
Kidney, Ureter, Bladder - changes in bladder weight
Endocrine - changes in spleen weight
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 4,833,1970
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 7280 mg/kg
SEX/DURATION : female 26 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 4,833,1970
*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
| NAME | CAS |
1H-1,4-Benzodiazepine-1-carboxamide,2,3-dihydro-N-methyl-7-nitro-2-oxo-5-phenyl-
| 27016-91-7 |
1H-1,5-Benzodiazepine-1-carboxamide,2,3,4,5-tetrahydro-2-methyl-4-oxo-
| 89647-50-7 |
1H-1,4-Benzodiazepine-3-carboxylic acid,7-chloro-2,3-dihydro-2-oxo-5-phenyl-, monopotassiumsalt, compd. with potassium hydroxide
| 57109-90-7 |
1H-1,4-Benzodiazepine-3-carboxylic acid,7-chloro-5-(2-fluorophenyl)-2,3-dihydro-2-oxo-, ethylester
| 29177-84-2 |
1H-1,4-Benzodiazepine-3-carboxylic acid,2,3-dihydro-7-chloro-5-(2-chlorophenyl)-1-((methylamino)carbonyl)-2-oxo-, ethyl ester
| 65400-84-2 |
1H-1,4-Benzodiazepine-3-carboxylic acid,2,3-dihydro-7-chloro-5-(2-fluorophenyl)-1-((methylamino)carbonyl)-2-oxo-, ethyl ester
| 65400-85-3 |
5H-Benzocyclohepten-7-amine, 6,7-dihydro-N-methyl-,hydrochloride, (+)-
| 62819-45-8 |
1H-1,4-Benzodiazepine-3-carboxylic acid,2,3-dihydro-7-chloro-2-oxo-5-phenyl-, monopotassiumsalt
| 5991-71-9 |
1H-1,4-Benzodiazepine-3-carboxylic acid,2,3-dihydro-7-chloro-2-oxo-5-phenyl-, phenyl ester
| 5991-71-9 |
1H-1,4-Benzodiazepine-3-carboxylic acid,2,3-dihydro-7-nitro-2-oxo-5-phenyl-, monopotassiumsalt
| 5571-84-6 |
1H-1,5-Benzodiazepine-2-carboxylic acid,5,5'-(1,2-dioxo-1,2-ethanediyl)bis(2,3,4,5-tetrahydro-2-methyl-4-phenyl-, diethyl ester
| 144401-02-5 |
1H-1,4-Benzodiazepine-3-carboxylic acid,2-hydroxy-7-nitro-5-phenyl-, monopotassium salt,compd. with potassium hydroxide
| 24477-47-2 |
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5-tetrahydro-5-acetyl-4-methyl-, ethyl ester
| 121635-52-7 |
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5,-tetrahydro-5-acetyl-2-methyl-4- phenyl-,ethyl ester
| 92911-27-8 |
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5-tetrahydro-5-benzoyl-4-methyl-, ethyl ester
| 121635-55-0 |
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5,-tetrahydro-5-benzoyl-2-methyl-4- phenyl-,ethyl ester
| 92942-83-1 |
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5-tetrahydro-5-((bis(2-methylpropyl)amino)acetyl)-4-methyl-, ethyl ester
| 121635-59-4 |
5H-Benzocyclohepten-7-amine,6,7-dihydro-N-methyl-9-phenyl-, hydrochloride
| 62819-50-5 |
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5-tetrahydro-5-(chloroacetyl)-4-methyl-, ethylester
| 121635-53-8 |
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5,-tetrahydro-5-(chloroacetyl)-2-methyl-4-phenyl-, ethyl ester
| 92911-28-9 |
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5-tetrahydro-5-(4-chlorobenzoyl)-4-methyl-,ethyl ester
| 121635-56-1 |
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5,-tetrahydro-5-(4-chlorobenzoyl)-2-methyl-4-phenyl-, ethyl ester
| 92911-29-0 |
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5-tetrahydro-5-((diethylamino)acetyl)-4-methyl-, ethyl ester
| 121635-57-2 |
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5-tetrahydro-5-((dipropylamino)acetyl)-4-methyl-, ethyl ester
| 121635-58-3 |
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5-tetrahydro-4-methyl-, ethyl ester
| 87896-36-4 |
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5-tetrahydro-4-methyl-5-(4-morpholinylacetyl)-,ethyl ester
| 121635-60-7 |
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5-tetrahydro-4-methyl-5-(1-oxobutyl)-, ethylester
| 121635-54-9 |
1H-1,5-Benzodiazepine-1-carboxylic acid,2,3,4,5-tetrahydro-2-methyl-4-oxo-, ethyl ester
| 98987-10-1 |
5H-Benzocyclohepten-7-amine,6,7-dihydro-N-2-propenyl-, hydrochloride
| 62819-69-6 |
1H-1,5-Benzodiazepine-5-carboxylic acid,2,3,4,5-tetrahydro-4-methyl-2-oxo-, methyl ester
| 89647-48-3 |
1H-1,5-Benzodiazepine-1-carboxylic acid,2,3,4,5-tetrahydro-2-methyl-4-oxo-, phenyl ester
| 98987-11-2 |
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5-tetrahydro-2-methyl-5-(1-oxo-3-phenyl-2-propentyl)-4-phenyl-, ethyl ester
| 144401-01-4 |
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5,-tetrahydro-2-methyl-4-phenyl-, ethyl ester
| 87918-91-0 |
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5,-tetrahydro-2-methyl-4-phenyl-5-(1-oxopropyl)-, ethyl ester
| 92942-82-0 |
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5-tetrahydro-4-methyl-5-(1-piperidinylacetyl)-,ethyl ester
| 121635-61-8 |
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5-tetrahydro-4-phenyl-
| 87896-33-1 |
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5-tetrahydro-4-phenyl-, ethyl ester
| 87896-35-3 |
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5-tetrahydro-4-phenyl-, methyl ester
| 87896-34-2 |
3H-1,4-Benzodiazepine,7-chloro-2-(cyclopropylamino)-5-phenyl-, 4-oxide
| 3864-80-0 |
5H-Benzocyclohepten-7-amine,6,7,8,9-tetrahydro-5-(4-aminophenoxy)-N,N-dimethyl-,dihydrochloride, cis-
| 72575-47-4 |
3H-1,4-Benzodiazepine,7-chloro-2-((cyclopropylmethyl)amino)-5-phenyl-,4-oxide
| 15687-07-7 |
1H-1,4-Benzodiazepine,7-chloro-2,3-dihydro-1-methyl-5-phenyl-
| 2898-12-6 |
1H-1,4-Benzodiazepine,7-chloro-2,3-dihydro-1-methyl-5-phenyl-,monohydrochloride
| 2898-11-5 |
1H-1,4-Benzodiazepine, 7-chloro-2,3-dihydro-5-phenyl
| 1694-78-6 |
3H-1,4-Benzodiazepine,7-chloro-2-dimethylamino-5-phenyl-, 4-oxide
| 3693-14-9 |
3H-1,4-Benzodiazepine,7-chloro-2-(N-methoxymethyl-N-methylamino)-5-phenyl-,4-oxide
| 69353-35-1 |
3H-1,4-Benzodiazepine,7-chloro-2-(methylamino)-5-phenyl-, 4-oxide
| 58-25-3 |
3H-1,4-Benzodiazepine,7-chloro-2-(methylamino)-5-phenyl-, 4-oxide andbarbituric acid, 5-ethyl-5-phenyl- (5:3)
| 63917-56-6 |
3H-1,4-Benzodiazepine,7-chloro-2-methylamino-5-phenyl-, 4-oxide,monohydrochloride
| 438-41-5 |
3H-1,4-Benzodiazepine,7-chloro-2-methylamino-5-phenyl-, 4-oxide, mixed withsodium nitrite (1:1)
| 104639-49-8 |
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