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MSDS  : 1H-1,4-Benzodiazepine-3-carboxylic acid, 7-chloro-2,3-dihydro-2-oxo-5-phenyl-, monopotassium salt, compd. with potassium hydroxide
CAS  : 57109-90-7
SYNONYMS  : * AB 35616 * Abbott-35616 * AH 3232 * Belseren * Bipotassium chlorazepate * 4306 CB * CB 4306 * Chlorazepam * Chlorazepate dipotassium * Clorazepate dipotassium * Dipotassium chlorazepate * Dipotassium clorazepate * Mendon * Nevracten * Potassium 7-chloro-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-carboxylate KOH * Tencilan * Transene * Transilium * Tranxene * Tranxilen * Tranxilene * Tranxilium
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : DE8750000
CHEMICAL NAME : 1H-1,4-Benzodiazepine-3-carboxylic acid,
7-chloro-2,3-dihydro-2-oxo-5-phenyl-, monopotassium
salt, compd. with potassium hydroxide
CAS REGISTRY NUMBER : 57109-90-7
LAST UPDATED : 199504
DATA ITEMS CITED : 15
MOLECULAR FORMULA : C16-H10-Cl-N2-O3.K.H-K-O
MOLECULAR WEIGHT : 408.94
WISWESSER LINE NOTATION : T67 GM JN JU&TJ CG HQ HQ IVQ KR &-KA- 2
COMPOUND DESCRIPTOR : Drug
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* AB 35616
* Abbott-35616
* AH 3232
* Belseren
* Bipotassium chlorazepate
* 4306 CB
* CB 4306
* Chlorazepam
* Chlorazepate dipotassium
* Clorazepate dipotassium
* Dipotassium chlorazepate
* Dipotassium clorazepate
* Mendon
* Nevracten
* Potassium
7-chloro-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-carboxylate
KOH
* Tencilan
* Transene
* Transilium
* Tranxene
* Tranxilen
* Tranxilene
* Tranxilium

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 880 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 10,710,1979

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 31200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 10,710,1979

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1478 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,603,1973

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 279 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,603,1973

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 700 mg/kg
TOXIC EFFECTS :
Behavioral - sleep
Behavioral - muscle weakness
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 20,123,1970

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 290 mg/kg
TOXIC EFFECTS :
Behavioral - sleep
Behavioral - muscle weakness
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 20,123,1970

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 510 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,603,1973

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 173 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,603,1973

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 30 gm/kg/30D-C
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in adrenal weight
Related to Chronic Data - death
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,603,1973

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Human - woman
DOSE : 18 mg/kg
SEX/DURATION : female 25-39 week(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - other neonatal measures or effects
Reproductive - Effects on Newborn - biochemical and metabolic
Reproductive - Effects on Newborn - physical
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
France) V.1- 1946- Volume(issue)/page/year: 36,305,1981

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Human - woman
DOSE : 54600 ug/kg
SEX/DURATION : female 1-39 week(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - other neonatal measures or effects
Reproductive - Effects on Newborn - physical
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
France) V.1- 1946- Volume(issue)/page/year: 36,305,1981

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE : 96 mg/kg
SEX/DURATION : female 8-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
Reproductive - Effects on Newborn - behavioral
REFERENCE :
ARNEAS Archives of Neurology (Chicago). (AMA, 535 N. Dearborn St., Chicago,
IL 60610) V.3- 1960- Volume(issue)/page/year: 37,350,1980

** MUTATION DATA **

TYPE OF TEST : Sex chromosome loss and nondisjunction
TEST SYSTEM : Mold - Aspergillus nidulans
DOSE/DURATION : 1 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 26,159,1974

*** REVIEWS ***

TOXICOLOGY REVIEW
DNSYAG Diseases of the Nervous System. (Memphis, TN) V.1-38, 1940-77. For
publisher information, see JCLPDE. Volume(issue)/page/year: 36,23,1975

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5402
No. of Facilities: 27 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 668 (estimated)
No. of Female Employees: 492 (estimated)


*** END OF RECORD ***
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ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP
NAMECAS
1H-1,4-Benzodiazepine-1-carboxamide,2,3-dihydro-N-methyl-7-nitro-2-oxo-5-phenyl- 27016-91-7
1H-1,5-Benzodiazepine-1-carboxamide,2,3,4,5-tetrahydro-2-methyl-4-oxo- 89647-50-7
1H-1,4-Benzodiazepine-3-carboxylic acid,7-chloro-2,3-dihydro-2-oxo-5-phenyl-, monopotassiumsalt, compd. with potassium hydroxide 57109-90-7
1H-1,4-Benzodiazepine-3-carboxylic acid,7-chloro-5-(2-fluorophenyl)-2,3-dihydro-2-oxo-, ethylester 29177-84-2
1H-1,4-Benzodiazepine-3-carboxylic acid,2,3-dihydro-7-chloro-5-(2-chlorophenyl)-1-((methylamino)carbonyl)-2-oxo-, ethyl ester 65400-84-2
1H-1,4-Benzodiazepine-3-carboxylic acid,2,3-dihydro-7-chloro-5-(2-fluorophenyl)-1-((methylamino)carbonyl)-2-oxo-, ethyl ester 65400-85-3
5H-Benzocyclohepten-7-amine, 6,7-dihydro-N-methyl-,hydrochloride, (+)- 62819-45-8
1H-1,4-Benzodiazepine-3-carboxylic acid,2,3-dihydro-7-chloro-2-oxo-5-phenyl-, monopotassiumsalt 5991-71-9
1H-1,4-Benzodiazepine-3-carboxylic acid,2,3-dihydro-7-chloro-2-oxo-5-phenyl-, phenyl ester 5991-71-9
1H-1,4-Benzodiazepine-3-carboxylic acid,2,3-dihydro-7-nitro-2-oxo-5-phenyl-, monopotassiumsalt 5571-84-6
1H-1,5-Benzodiazepine-2-carboxylic acid,5,5'-(1,2-dioxo-1,2-ethanediyl)bis(2,3,4,5-tetrahydro-2-methyl-4-phenyl-, diethyl ester 144401-02-5
1H-1,4-Benzodiazepine-3-carboxylic acid,2-hydroxy-7-nitro-5-phenyl-, monopotassium salt,compd. with potassium hydroxide 24477-47-2
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5-tetrahydro-5-acetyl-4-methyl-, ethyl ester 121635-52-7
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5,-tetrahydro-5-acetyl-2-methyl-4- phenyl-,ethyl ester 92911-27-8
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5-tetrahydro-5-benzoyl-4-methyl-, ethyl ester 121635-55-0
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5,-tetrahydro-5-benzoyl-2-methyl-4- phenyl-,ethyl ester 92942-83-1
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5-tetrahydro-5-((bis(2-methylpropyl)amino)acetyl)-4-methyl-, ethyl ester 121635-59-4
5H-Benzocyclohepten-7-amine,6,7-dihydro-N-methyl-9-phenyl-, hydrochloride 62819-50-5
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5-tetrahydro-5-(chloroacetyl)-4-methyl-, ethylester 121635-53-8
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5,-tetrahydro-5-(chloroacetyl)-2-methyl-4-phenyl-, ethyl ester 92911-28-9
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5-tetrahydro-5-(4-chlorobenzoyl)-4-methyl-,ethyl ester 121635-56-1
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5,-tetrahydro-5-(4-chlorobenzoyl)-2-methyl-4-phenyl-, ethyl ester 92911-29-0
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5-tetrahydro-5-((diethylamino)acetyl)-4-methyl-, ethyl ester 121635-57-2
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5-tetrahydro-5-((dipropylamino)acetyl)-4-methyl-, ethyl ester 121635-58-3
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5-tetrahydro-4-methyl-, ethyl ester 87896-36-4
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5-tetrahydro-4-methyl-5-(4-morpholinylacetyl)-,ethyl ester 121635-60-7
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5-tetrahydro-4-methyl-5-(1-oxobutyl)-, ethylester 121635-54-9
1H-1,5-Benzodiazepine-1-carboxylic acid,2,3,4,5-tetrahydro-2-methyl-4-oxo-, ethyl ester 98987-10-1
5H-Benzocyclohepten-7-amine,6,7-dihydro-N-2-propenyl-, hydrochloride 62819-69-6
1H-1,5-Benzodiazepine-5-carboxylic acid,2,3,4,5-tetrahydro-4-methyl-2-oxo-, methyl ester 89647-48-3
1H-1,5-Benzodiazepine-1-carboxylic acid,2,3,4,5-tetrahydro-2-methyl-4-oxo-, phenyl ester 98987-11-2
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5-tetrahydro-2-methyl-5-(1-oxo-3-phenyl-2-propentyl)-4-phenyl-, ethyl ester 144401-01-4
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5,-tetrahydro-2-methyl-4-phenyl-, ethyl ester 87918-91-0
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5,-tetrahydro-2-methyl-4-phenyl-5-(1-oxopropyl)-, ethyl ester 92942-82-0
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5-tetrahydro-4-methyl-5-(1-piperidinylacetyl)-,ethyl ester 121635-61-8
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5-tetrahydro-4-phenyl- 87896-33-1
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5-tetrahydro-4-phenyl-, ethyl ester 87896-35-3
1H-1,5-Benzodiazepine-2-carboxylic acid,2,3,4,5-tetrahydro-4-phenyl-, methyl ester 87896-34-2
3H-1,4-Benzodiazepine,7-chloro-2-(cyclopropylamino)-5-phenyl-, 4-oxide 3864-80-0
5H-Benzocyclohepten-7-amine,6,7,8,9-tetrahydro-5-(4-aminophenoxy)-N,N-dimethyl-,dihydrochloride, cis- 72575-47-4
3H-1,4-Benzodiazepine,7-chloro-2-((cyclopropylmethyl)amino)-5-phenyl-,4-oxide 15687-07-7
1H-1,4-Benzodiazepine,7-chloro-2,3-dihydro-1-methyl-5-phenyl- 2898-12-6
1H-1,4-Benzodiazepine,7-chloro-2,3-dihydro-1-methyl-5-phenyl-,monohydrochloride 2898-11-5
1H-1,4-Benzodiazepine, 7-chloro-2,3-dihydro-5-phenyl 1694-78-6
3H-1,4-Benzodiazepine,7-chloro-2-dimethylamino-5-phenyl-, 4-oxide 3693-14-9
3H-1,4-Benzodiazepine,7-chloro-2-(N-methoxymethyl-N-methylamino)-5-phenyl-,4-oxide 69353-35-1
3H-1,4-Benzodiazepine,7-chloro-2-(methylamino)-5-phenyl-, 4-oxide 58-25-3
3H-1,4-Benzodiazepine,7-chloro-2-(methylamino)-5-phenyl-, 4-oxide andbarbituric acid, 5-ethyl-5-phenyl- (5:3) 63917-56-6
3H-1,4-Benzodiazepine,7-chloro-2-methylamino-5-phenyl-, 4-oxide,monohydrochloride 438-41-5
3H-1,4-Benzodiazepine,7-chloro-2-methylamino-5-phenyl-, 4-oxide, mixed withsodium nitrite (1:1) 104639-49-8

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