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MSDS  : Benzoic acid, p-hydroxy-, ethyl ester
CAS  : 120-47-8
SYNONYMS  : * Aseptoform E * Bonomold OE * p-Carbethoxyphenol * Easeptol * Ester etylowykwasu p-hydroksybenzoesowego * Ethylester kyseliny p-hydroxybenzoove * Ethyl p-hydroxybenzoate * Ethyl p-oxybenzoate * Ethyl paraben * Ethyl parasept * p-Hydroxybenzoic acid ethyl ester * p-Hydroxybenzoic ethyl ester * Nipagin A * Nipagina A * Nipazin A * p-Oxybenzoesaeureaethylester * Solbrol A * Tegosept E
*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER : DH2190000
CHEMICAL NAME : Benzoic acid, p-hydroxy-, ethyl ester
CAS REGISTRY NUMBER : 120-47-8
BEILSTEIN REFERENCE NO. : 1101972
REFERENCE : 4-10-00-00367 (Beilstein Handbook Reference)
LAST UPDATED : 199701
DATA ITEMS CITED : 15
MOLECULAR FORMULA : C9-H10-O3
MOLECULAR WEIGHT : 166.19
WISWESSER LINE NOTATION : QR DVO2
COMPOUND DESCRIPTOR : Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Aseptoform E
* Bonomold OE
* p-Carbethoxyphenol
* Easeptol
* Ester etylowykwasu p-hydroksybenzoesowego
* Ethylester kyseliny p-hydroxybenzoove
* Ethyl p-hydroxybenzoate
* Ethyl p-oxybenzoate
* Ethyl paraben
* Ethyl parasept
* p-Hydroxybenzoic acid ethyl ester
* p-Hydroxybenzoic ethyl ester
* Nipagin A
* Nipagina A
* Nipazin A
* p-Oxybenzoesaeureaethylester
* Solbrol A
* Tegosept E

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AOGLAR Acta Obstetrica et Gynaecologica Japonica, English Edition. (Tokyo,
Japan) V.16-23, 1969-76. For publisher information, see NISFAY.
Volume(issue)/page/year: 22,94,1975

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068
Warsaw 1, Poland) V.4- 1971- Volume(issue)/page/year: 14,301,1981

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 520 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRSTAT Drug Standards. (Washington, DC) V.19-28, 1951-60. For publisher
information, see JPMSAE. Volume(issue)/page/year: 20,89,1952

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 53A,81,1974

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 53A,81,1974

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 53A,81,1974

** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 504 gm/kg/12W-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see
JPMSAE. Volume(issue)/page/year: 45,260,1956

** REPRODUCTIVE DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 45600 mg/kg
SEX/DURATION : female 8-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
AOGLAR Acta Obstetrica et Gynaecologica Japonica, English Edition. (Tokyo,
Japan) V.16-23, 1969-76. For publisher information, see NISFAY.
Volume(issue)/page/year: 22,94,1975

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 10 mmol/L
REFERENCE :
ZBPIA9 Zentralblatt fuer Bakteriologie, Parasitenkunde,
Infektionskrankheiten und Hygiene, Abteilung II. Naturwissenschaftliche:
Allgemeine, Landwirtschaftliche und Technische Mikrobiologie. (Jena, Ger.
Dem. Rep.) V.107-132, 1952-77. Volume(issue)/page/year: 112,226,1959

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Fibroblast
DOSE/DURATION : 250 mg/L
REFERENCE :
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic
Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year:
(96),55,1978

TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 440 mg/L
REFERENCE :
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring
St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year:
27,95,1981

*** REVIEWS ***

TOXICOLOGY REVIEW
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 4,575,1954

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 82869
No. of Facilities: 103 (estimated)
No. of Industries: 3
No. of Occupations: 7
No. of Employees: 3241 (estimated)

NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 82869
No. of Facilities: 307 (estimated)
No. of Industries: 6
No. of Occupations: 7
No. of Employees: 4591 (estimated)
No. of Female Employees: 1145 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY


*** END OF RECORD ***
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NAMECAS
Benzoic acid, 4-(4-hydroxybutyl)- 58973-64-1
Benzoic acid, p-hydroxy-, butyl ester 94-26-8
Benzoic acid, 3,4-diiodo- 35674-20-5
Benzoic acid, p-hydroxy-, butyl ester, sodium salt 36457-20-2
Benzoic acid, p-((4-hydroxycarbaniloyl)oxy)-, methylester, ester with bis(1-aziridinyl) phosphinate 41363-21-7
Benzoic acid, 2-hydroxy-, 2-carboxyphenyl ester 552-94-3
Benzoic acid, 2-hydroxy-, 2-carboxyphenyl ester,monosodium salt 23520-54-9
Benzoic acid, 2-hydroxy-,2-(7-chloro-2H-1,4-benzothiazin-3-yl)hydrazide 78959-18-9
Benzoic acid, 4-hydroxy-,2-(7-chloro-2H-1,4-benzothiazin-3-yl)hydrazide 78959-19-0
Benzoic acid, 2-hydroxy-,2-(((2-chloroethyl)nitrosoamino)carbonyl)hydrazide 147217-63-8
Benzoic acid, 2-hydroxy-,(1-(2-chlorophenyl)ethylidene)hydrazide, (E)- 133662-01-8
Benzoic acid, 2-hydroxy-, cyclohexyl ester 25485-88-5
Benzoic acid, p-hydroxy-, decyl ester 69679-30-7
Benzoic acid,4-(((4,5-dihydro-4-oxo-3H-1,2,3-triazino(5,4-b)indol-3-yl)imino)methyl)- 139953-77-8
Benzoic acid, 3,5-diiodo- 19094-48-5
Benzoic acid, 4-hydroxy-3,5-dimethoxy- 530-57-4
Benzoic acid, o-hydroxy-,3-(2,3-dimethylpiperidino)propyl ester, hydrochloride 67049-52-9
Benzoic acid, o-hydroxy-,3-(2,4-dimethylpiperidino)propyl ester, hydrochloride 67049-53-0
Benzoic acid, o-hydroxy-,3-(2,5-dimethylpiperidino)propyl ester, hydrochloride 67032-02-4
Benzoic acid, o-hydroxy-,3-(2,6-dimethylpiperidino)propyl ester, hydrochloride 66591-54-6
Benzoic acid, 2-hydroxy-, compd. with4,6-dimethyl-N-(3,4,5-trimethoxyphenyl)-2-pyrimidinamine 94696-72-7
Benzoic acid, 2-hydroxy-,1,4-dioxaspiro(4.5)dec-2-ylmethyl ester 59902-29-3
Benzoic acid,4-((2-hydroxy-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)acetyl)- 70780-35-7
Benzoic acid,2-(2-hydroxy-1,4-dioxo-4-phenyl-2-butenyl)hydrazide,(Z)- 124928-27-4
Benzoic acid, 4-hydroxy-, diphenylsilylene ester 129459-90-1
Benzoic acid, 2-(3,5-diiodobenzenesulfonamido)- 129459-90-1
Benzoic acid, p-hydroxy-, dodecyl ester 2664-60-0
Benzoic acid, p-hydroxy-, ester with3-hydroxy-1-methyl-3-piperidyl phenyl ketone,monohydrochloride, (+-), hemihydrate 33422-53-6
Benzoic acid, p-hydroxy-, ester with(3-hydroxypropyl)guanidine, monohydrochloride 19623-22-4
Benzoic acid, o-(2-hydroxyethoxy)- 19623-22-4
Benzoic acid, 2-((2-hydroxyethyl)amino)- 25784-00-3
Benzoic acid,2-(((2-hydroxyethyl)amino)carbonyl)-3,4,5,6-tetraiodo- 25784-00-3
Benzoic acid,4-(((2-hydroxyethyl)amino)carbonyl)-2,3,5,6-tetraiodo- 34737-08-1
Benzoic acid, o-(2-hydroxyethyl)-,((1,2-dihydro-5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-2,7-(epoxypentadeca(1,11,13)trie nimino)naphtho(2,1-b)furan-8-yl)methylene)hydrazide, 21-acetate 38546-25-7
Benzoic acid, p-hydroxy-, ethyl ester 120-47-8
Benzoic acid, p-hydroxy-, ethyl ester, sodium deriv. 35285-68-8
Benzoic acid, 4-(3,5-diiodobenzenesulfonamido)- 35285-68-8
Benzoic acid,4-(((2-hydroxyethyl)methylamino)carbonyl)-2,3,5,6-tetraiodo- 34737-11-6
Benzoic acid,2-(5-((4-(2-hydroxyethyl)-1-piperazinyl)carbonyl)-1,3-benzodioxol-4-yl)-3, 4,5- trimethoxy-,2-methylphenyl ester 156809-19-7
Benzoic acid, p-hydroxy-, heptyl ester 1085-12-7
Benzoic acid, p-hydroxy-, heptyl ester, dihydrogenphosphate 27864-56-8
Benzoic acid, p-hydroxy-, hexyl ester 1083-27-8
Benzoic acid,2-hydroxy-5-(2-(2-hydroxybenzoyl)ethenyl)- 1083-27-8
Benzoic acid,2-hydroxy-5-(2-(2-hydroxy-5-iodobenzoyl)ethenyl)- 1083-27-8
Benzoic acid,2-hydroxy-4-((4-hydroxy-2-methoxy-3,5,6-trimethylbenzoyl)oxy)-3,5,6-trimet hyl-,4-carboxy-3-methoxy-2,5,6-trimethylphenyl ester 158792-23-5
Benzoic acid,p-(3-hydroxy-5-hydroxymethyl-2-methyl-4-pyridylmethyl)amino-, 2- diethylaminoethyl ester, dihydrochloride 73713-65-2
Benzoic acid,2-hydroxy-5-(6-hydroxy-4-oxo-4H-1-benzopyran-2-yl)- 126342-65-2
Benzoic acid, 3,5-diiodo-4-ethoxy-, hydrazide 23964-38-7
Benzoic acid,2-hydroxy-5-(1-hydroxy-2-(4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1- piperidinyl)ethyl)-, methyl ester 74406-01-2
Benzoic acid,2-hydroxy-5-(((4-hydroxyphenyl)amino)carbonyl)-,methyl ester 25334-08-1

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